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CAS 162442-15-1

1-(3-Hydroxy-4-methoxyphenyl)-3-(3,4,5-trimethoxyphenyl)propan-1-one

Codes: (XIV)70274-8-b

Application context (from source-drug indications)

Coronary artery lesionColchicineMyocardial infarctionColchicineStrokeColchicine痛风性关节炎Colchicine脑出血ColchicineAtrial fibrillationColchicine

Source drugs (routes using this intermediate)

DrugTierExpiry
ColchicineTier C — Watch / trade-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

ColchicineOptimised routesteps: 7total yield: /
3-Hydroxy-4-anisaldehyde→N-[(5S)-3-Hydroxy-2,9,10,11-tetramethoxy-6,7-dihydro-5H-dibenzo[a,c][7]annulen-5-yl]acetamide→3,4,5-Trimethoxybenzaldehyde→1-(3-Hydroxy-4-methoxyphenyl)-3-(3,4,5-trimethoxyphenyl)prop-2-en-1-one→1-(3-Hydroxy-4-methoxyphenyl)-3-(3,4,5-trimethoxyphenyl)propan-1-one→tert-Butyl[[(5S)-3-hydroxy-2,9,10,11-tetramethoxy-6,7-dihydro-5H-dibenzo[a,c][7]annulen-5-yl]amino]sulfaniumolate→1-[3-(Benzyloxy)-4-methoxyphenyl]-3-(3,4,5-trimethoxyphenyl)propan-1-one→(R)-(+)-2-Methyl-2-propanesulfinamide→[[(1S)-1-[3-(Benzyloxy)-4-methoxyphenyl]-3-(3,4,5-trimethoxyphenyl)propyl]amino](tert-butyl)sulfaniumolate→tert-Butyl[[(1S)-1-(3-hydroxy-4-methoxyphenyl)-3-(3,4,5-trimethoxyphenyl)propyl]amino]sulfaniumolate→Acetic acid chloride

Intermediates available on this site

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