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CAS 2098884-52-5
(3-((4-(aminomethyl)-6-(trifluoromethyl)pyridin-2-yl)oxy)phenyl)((3R,4R)-3-fluoro-4-hydroxypyrrolidin-1-yl)methanone
Codes: PAT-1251-009
Application context (from source-drug indications)
MyelofibrosisLenumlostat hydrochlorideEssential thrombocythaemiaLenumlostat hydrochloridePolycythaemia veraLenumlostat hydrochloride
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Lenumlostat hydrochloride | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
2-chloro-6-(trifluoromethyl)isonicotinonitrile→methyl 3-hydroxybenzoate→methyl 3-((4-cyano-6-(trifluoromethyl)pyridin-2-yl)oxy)benzoate→methyl 3-((4-(aminomethyl)-6-(trifluoromethyl)pyridin-2-yl)oxy)benzoate→methyl 3-((4-(((tert-butoxycarbonyl)amino)methyl)-6-(trifluoromethyl)pyridin-2-yl)oxy)benzoate→3-((4-(((tert-butoxycarbonyl)amino)methyl)-6-(trifluoromethyl)pyridin-2-yl)oxy)benzoic acid→(3S,4S)-4-fluoropyrrolidin-3-ol hydrochloride→tert-butyl ((2-(3-(3-fluoro-4-hydroxypyrrolidine-1-carbonyl)phenoxy)-6-(trifluoromethyl)pyridin-4-yl)methyl)carbamate→(3-((4-(aminomethyl)-6-(trifluoromethyl)pyridin-2-yl)oxy)phenyl)((3R,4R)-3-fluoro-4-hydroxypyrrolidin-1-yl)methanone
Intermediates available on this site
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