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CAS 58584-83-1
2,6-dichloronicotinoyl chloride
Codes: CX-5461-002
Application context (from source-drug indications)
Colorectal cancerPidnarulexSolid tumourPidnarulexBurkitt淋巴瘤PidnarulexB-cell lymphomaPidnarulexLymphomaPidnarulexHR阳性乳腺癌Pidnarulex
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Pidnarulex | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
2-(4-methyl-1,4-diazepan-1-yl)-N-((5-methylpyrazin-2-yl)methyl)-5-oxo-5H-benzo[4,5]thiazolo[3,2-a][1,8]naphthyridine-6-carboxamide→2,6-dichloronicotinic acid→2,6-dichloronicotinoyl chloride→ethyl 2-(benzo[d]thiazol-2-yl)acetate→ethyl 2-chloro-5-oxo-5H-benzo[4,5]thiazolo[3,2-a][1,8]naphthyridine-6-carboxylate→1-methyl-1,4-diazepane→ethyl 2-(4-methyl-1,4-diazepan-1-yl)-5-oxo-5H-benzo[4,5]thiazolo[3,2-a][1,8]naphthyridine-6-carboxylate→(5-methylpyrazin-2-yl)methanamine
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