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CAS 86780-80-5

(2-methyl-1,3-dioxolan-2-yl)methyl 3-oxobutanoate

Codes: (III)122198-1-a, (IV)122198-2-a

Application context (from source-drug indications)

HypertensionAranidipine

Source drugs (routes using this intermediate)

DrugTierExpiry
AranidipineTier C — Watch / trade-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

AranidipineOptimised routesteps: 4total yield: /
4-Methylene-2-oxetanone→(2-Methyl-1,3-dioxolan-2-yl)methanol→(2-methyl-1,3-dioxolan-2-yl)methyl 3-oxobutanoate→2-Formyl-3-nitrobenzene→(2-methyl-1,3-dioxolan-2-yl)methyl (2Z)-2-[(2-nitrophenyl)methylidene]-3-oxobutanoate→3-Amino-2-butenoic acid methyl ester→3-methyl 5-(2-methyl-1,3-dioxolan-2-yl)methyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate→(2-methyl-1,3-dioxolan-2-yl)methyl (2E)-3-aminobut-2-enoate→Methyl (2Z)-2-[(2-nitrophenyl)methylidene]-3-oxobutanoate
AranidipineOptimised routesteps: 2total yield: /
1-Hydroxyacetone→(2-Methyl-1,3-dioxolan-2-yl)methanol→4-Methylene-2-oxetanone→(2-methyl-1,3-dioxolan-2-yl)methyl 3-oxobutanoate

Intermediates available on this site

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