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CAS 875551-28-3
2'-(chloromethyl)-4-fluoro-5-isopropyl-2-methoxy-4'-(trifluoromethyl)-1,1'-biphenyl
Codes: ANAC-020
Application context (from source-drug indications)
HypercholesterolaemiaAnacetrapibCardiac and vascular disordersAnacetrapibDyslipidaemiaAnacetrapibAtherosclerosisAnacetrapibHyperlipoproteinaemia type IIAnacetrapibHomozygous familial hypercholesterolaemiaAnacetrapib
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Anacetrapib | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
2-iodo-4-(trifluoromethyl)aniline→2-amino-5-(trifluoromethyl)benzonitrile→2-iodo-5-(trifluoromethyl)benzonitrile →2-iodo-5-(trifluoromethyl)benzoic acid→[2-iodo-5-(trifluoromethyl)phenyl]methanol →(4S,5R)-5-(3,5-bis(trifluoromethyl)phenyl)-4-methyloxazolidin-2-one→(4-fluoro-5-isopropyl-2-methoxyphenyl)boronic acid→(4'-fluoro-5'-isopropyl-2'-methoxy-4-(trifluoromethyl)-[1,1'-biphenyl]-2-yl)methanol→2'-(chloromethyl)-4-fluoro-5-isopropyl-2-methoxy-4'-(trifluoromethyl)-1,1'-biphenyl→(S)-2-(((benzyloxy)carbonyl)amino)propanoic acid→N,O-dimethylhydroxylamine→1-bromo-3,5-bis(trifluoromethyl)benzene→1-bromo-3,5-bis(trifluoromethyl)benzene→benzyl (S)-(1-(3,5-bis(trifluoromethyl)phenyl)-1-oxopropan-2-yl)carbamate→benzyl ((1R,2S)-1-(3,5-bis(trifluoromethyl)phenyl)-1-hydroxypropan-2-yl)carbamate
1-bromo-4-fluoro-5-isopropyl-2-methoxybenzene→(4'-fluoro-5'-isopropyl-2'-methoxy-4-(trifluoromethyl)-[1,1'-biphenyl]-2-yl)methanol→2'-(chloromethyl)-4-fluoro-5-isopropyl-2-methoxy-4'-(trifluoromethyl)-1,1'-biphenyl→1-bromo-2,4-difluorobenzene→1-bromo-4-fluoro-2-methoxybenzene→acetyl chloride→1-(5-bromo-2-fluoro-4-methoxyphenyl)ethan-1-one→2-(5-bromo-2-fluoro-4-methoxyphenyl)propan-2-ol→2-(3-(trifluoromethyl)phenyl)-4,5-dihydrooxazole→2-(4'-fluoro-5'-isopropyl-2'-methoxy-4-(trifluoromethyl)-[1,1'-biphenyl]-2-yl)-4,5-dihydrooxazole→methyl carbonochloridate→methyl (2-chloroethyl)(4'-fluoro-5'-isopropyl-2'-methoxy-4-(trifluoromethyl)-[1,1'-biphenyl]-2-carbonyl)carbamate
(4S,5R)-5-(3,5-bis(trifluoromethyl)phenyl)-4-methyloxazolidin-2-one→nitroethane→2'-(chloromethyl)-4-fluoro-5-isopropyl-2-methoxy-4'-(trifluoromethyl)-1,1'-biphenyl→3,5-diiodobenzaldehyde→(1R,2S)-1-(3,5-diiodophenyl)-2-nitropropan-1-ol→(4S,5R)-5-(3,5-diiodophenyl)-4-methyloxazolidin-2-one
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