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CAS 876403-99-5
((3aS,5aR,8aR,8bS)-2,2,7,7-tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4',5'-d]pyran-3a-yl)methyl methyl(phenyl)carbamoylsulfamate
Codes: TOPIR-008
Application context (from source-drug indications)
EpilepsyTopiramateLennox-Gastaut syndromeTopiramateSeizureTopiramateTonic-clonic seizureTopiramatePartial-onset seizureTopiramateMigraineTopiramate
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Topiramate | Tier B — Position early | - |
Position in synthesis routes (up/downstream chain)
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((3aS,5aR,8aR,8bS)-2,2,7,7-tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4',5'-d]pyran-3a-yl)methanol→sulfurisocyanatidic chloride→N-methylaniline→(methyl(phenyl)carbamoyl)sulfamoyl chloride→((3aS,5aR,8aR,8bS)-2,2,7,7-tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4',5'-d]pyran-3a-yl)methyl methyl(phenyl)carbamoylsulfamate
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