CAS 89979-13-5

benzyl chlorosulfonylcarbamate

Codes: TOPIR-009

Application context (from source-drug indications)

EpilepsyTopiramateLennox-Gastaut syndromeTopiramateSeizureTopiramateTonic-clonic seizureTopiramatePartial-onset seizureTopiramateMigraineTopiramate

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
Topiramate	Tier B — Position early	-

Position in synthesis routes (up/downstream chain)

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TopiramateOptimised routesteps: 3total yield: 65 g

((3aS,5aR,8aR,8bS)-2,2,7,7-tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4',5'-d]pyran-3a-yl)methanol→sulfurisocyanatidic chloride→benzyl chlorosulfonylcarbamate→((3aS,5aR,8aR,8bS)-2,2,7,7-tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4',5'-d]pyran-3a-yl)methyl (benzyloxy)carbonylsulfamate

Intermediates available on this site

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