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CAS 90965-06-3

1-(Dimethoxyphosphoryl)-2-oxopropane-1-diazonium

Codes: (V)70274-7-a

Application context (from source-drug indications)

Coronary artery lesionColchicineMyocardial infarctionColchicineStrokeColchicine痛风性关节炎Colchicine脑出血ColchicineAtrial fibrillationColchicine

Source drugs (routes using this intermediate)

DrugTierExpiry
ColchicineTier C — Watch / trade-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

ColchicineOptimised routesteps: 7total yield: /
2,3,4-Trimethoxybenzaldehyde→N-Methoxy-N-methylprop-2-enamide→(2E)-3-(2-Formyl-3,4,5-trimethoxyphenyl)-N-methoxy-N-methylprop-2-enamide→3-(2-Formyl-3,4,5-trimethoxyphenyl)-N-methoxy-N-methylpropanamide→1-(Dimethoxyphosphoryl)-2-oxopropane-1-diazonium→3-(2-Ethynyl-3,4,5-trimethoxyphenyl)-N-methoxy-N-methylpropanamide→2-(Hydroxymethyl)furan→3-(2-Ethynyl-3,4,5-trimethoxyphenyl)-1-[5-(hydroxymethyl)furan-2-yl]propan-1-one→(R)-(+)-2-Methyl-2-propanesulfinamide→tert-Butyl[(Z)-[3-(2-ethynyl-3,4,5-trimethoxyphenyl)-1-[5-(hydroxymethyl)furan-2-yl]propylidene]amino]sulfaniumolate→tert-Butyl([(1S)-3-(2-ethynyl-3,4,5-trimethoxyphenyl)-1-[5-(hydroxymethyl)furan-2-yl]propyl]amino)sulfaniumolate→[5-[(1S)-1-Amino-3-(2-ethynyl-3,4,5-trimethoxyphenyl)propyl]furan-2-yl]methanol→N-[(7S,7aR,10S,11R)-9-Iodo-1,2,3,10-tetramethoxy-6,7,10,11-tetrahydro-5H-7a,11-epoxybenzo[a]heptalen-7-yl]acetamide→Carbonic acid dimethyl diester

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