Apitolisib
Tier C — Watch / tradeApitolisib
Targets：mTORC1, mTORC2, Class I PI3K
Indications (approved)：Prostate cancer, Breast cancer, Solid tumour, Renal cell carcinoma, Non-Hodgkin lymphoma, Endometrial cancer
Regional status
Synthetic routes & intermediates1 routes
Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.
| Code | CAS No. | Intermediate |
|---|---|---|
| APITO-001 | 85006-31-1Available | methyl 3-amino-4-methylthiophene-2-carboxylate |
| APITO-002 | 35265-81-7 | 7-methylthieno[3,2-d]pyrimidine-2,4(1H,3H)-dione |
| APITO-003 | 35265-83-9 | 2,4-dichloro-7-methylthieno[3,2-d]pyrimidine |
| APITO-004 | 35265-88-4 | 4-(2-chloro-7-methylthieno[3,2-d]pyrimidin-4-yl)morpholine |
| APITO-005 | 955979-02-9 | 2-chloro-7-methyl-4-morpholinothieno[3,2-d]pyrimidine-6-carbaldehyde |
| APITO-006 | 1592609-60-3 | (S)-2-hydroxy-1-(piperazin-1-yl)propan-1-one oxalate |
| APITO-007 | 1032757-58-6 | (S)-1-(4-((2-chloro-7-methyl-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)piperazin-1-yl)-2-hydroxypropan-1-one |
| APITO-008 | 936250-22-5 | (2-aminopyrimidin-5-yl)boronic acid |
| APITO-009 | 687-47-8 | ethyl (S)-2-hydroxypropanoate |
| APITO-010 | 1401334-41-5 | (S)-2-hydroxy-1-(piperazin-1-yl)propan-1-one |
| APITO-011 | 7752-82-1 | 5-bromopyrimidin-2-amine |
| APITO-012 | 209959-33-1 | - |
Frequently asked questions
What are the approved indications of Apitolisib?
Approved indications include: Prostate cancer, Breast cancer, Solid tumour, Renal cell carcinoma, Non-Hodgkin lymphoma, Endometrial cancer.
When does the Apitolisib patent expire?
No public expiry year is available for Apitolisib yet; this page updates once verified.
How many synthesis routes are recorded for Apitolisib?
1 synthesis routes are recorded; the shortest is 10 steps with 15.1 kg total yield. Intermediates in each route carry codes and CAS numbers.
Where can I buy Apitolisib intermediates?
1 intermediate CAS of Apitolisib are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.
How do I get a quote for Apitolisib intermediates?
Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.
Source: cross-verified data (structured fields only) · 2026-10-19