Pimecrolimus

Tier C — Watch / trade

Pimecrolimus

Novartis

Originator

2001

First approval

Expiry (public)

$0.37B ▲

Peak sales

Small molecule

Type

Targets：Calcineurin, FKBP1A

Brand：Elidel

Indications (approved)：Eczema, Atopic dermatitis

Regional status

Approved

2001-12-13

No progress

2001-12-01

China

Approved

2005-09-29

Japan

No progress

2004-05-01

Synthetic routes & intermediates5 routes

Originator routes × 1Optimised (non-patent) × 4Process routes × 0

Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.

OriginatorRoute 1Steps 4 · Total yield /

PIME-001135635-46-0PIME-002137071-45-5PIME-003137820-27-0PIME-004138232-92-5API · Pimecrolimus

Code	CAS No.	Intermediate
PIME-001	135635-46-0	15,19-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone, 8-ethyl-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26ahexadecahydro-5,19-dihydroxy-3-[2-(4-hydroxy-3-methoxycyclohexyl)-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-
PIME-002	137071-45-5	15,19-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone, 5-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3-[(1E)-2-[(1R,3R,4R)-4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3-methoxycyclohexyl]-1-methylethenyl]-8-ethyl-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-19-hydroxy-14,16-dimethoxy-4,10,12,18-tetramethyl-, (3S,4S,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-
PIME-003	137820-27-0	15,19-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone, 5-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-8-ethyl-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-19-hydroxy-3-[(1E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-, (3S,4S,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-
PIME-004	138232-92-5	15,19-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone, 3-[2-(4-chloro-3-methoxycyclohexyl)-1-methylethenyl]-5-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-19-hydroxy-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propenyl)-, [3S-[3R[E(1S,3S,4R)],4R,5R,8S,9E,12R,14R,15S,16R,18S,19S,26aR]]- (9CI)

OptimisedRoute 2Steps 1 · Total yield /

PIME-001135635-46-0API · Pimecrolimus

Code	CAS No.	Intermediate
PIME-001	135635-46-0	15,19-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone, 8-ethyl-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26ahexadecahydro-5,19-dihydroxy-3-[2-(4-hydroxy-3-methoxycyclohexyl)-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-

OptimisedRoute 3Steps 1 · Total yield /

PIME-001135635-46-0API · Pimecrolimus

Code	CAS No.	Intermediate
PIME-001	135635-46-0	15,19-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone, 8-ethyl-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26ahexadecahydro-5,19-dihydroxy-3-[2-(4-hydroxy-3-methoxycyclohexyl)-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-

OptimisedRoute 4Steps 1 · Total yield 2.54 g

PIME-001135635-46-0API · Pimecrolimus

Code	CAS No.	Intermediate
PIME-001	135635-46-0	15,19-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone, 8-ethyl-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26ahexadecahydro-5,19-dihydroxy-3-[2-(4-hydroxy-3-methoxycyclohexyl)-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-

OptimisedRoute 5Steps 1 · Total yield 16.65 g

PIME-001135635-46-0API · Pimecrolimus

Code	CAS No.	Intermediate
PIME-001	135635-46-0	15,19-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone, 8-ethyl-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26ahexadecahydro-5,19-dihydroxy-3-[2-(4-hydroxy-3-methoxycyclohexyl)-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-

Frequently asked questions

What are the approved indications of Pimecrolimus?

Approved indications include: Eczema, Atopic dermatitis.

When does the Pimecrolimus patent expire?

No public expiry year is available for Pimecrolimus yet; this page updates once verified.

How many synthesis routes are recorded for Pimecrolimus?

5 synthesis routes are recorded; the shortest is 1 steps with / total yield. Intermediates in each route carry codes and CAS numbers.

Where can I buy Pimecrolimus intermediates?

All intermediates in Pimecrolimus routes have CAS profiles — you can submit an RFQ per CAS and it enters the Unibest matching pool.

How do I get a quote for Pimecrolimus intermediates?

Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.

Source: cross-verified data (structured fields only) · 2026-09-29