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Ibandronate Sodium Hydrate

Tier C — Watch / trade

Ibandronate Sodium Hydrate

Genentech
Originator
1996
First approval
-
Expiry (public)
$0.78B ▲
Peak sales
Small molecule
Type

Targets:Bone resorption factor, FDPS

Brand:Bondronat, Bondenza, Bonviva (former Brand Name), Destara, Bonviva, Boniva/Bonviva, Boniva

Indications (approved):Osteoporosis, Postmenopausal osteoporosis, Hypercalcaemia, Bone injury, Breast cancer, Metastatic cancer

Regional status

US
Withdrawn
EU
Approved
1996-06-25
China
Approved
2001-01-01
Japan
Approved
2013-06-28

Synthetic routes & intermediates5 routes

Originator routes × 1Optimised (non-patent) × 4Process routes × 0

Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.

OriginatorRoute 1Steps 7 · Total yield /
IBAN-001110-58-7IBAN-002100-52-7IBAN-00322710-00-5IBAN-00425468-43-3IBAN-00577223-58-6IBAN-00625419-06-1IBAN-00796-33-3IBAN-008744266-99-7IBAN-009287395-61-3API · Ibandronate Sodium Hydrate
CodeCAS No.Intermediate
IBAN-001110-58-7pentan-1-amine
IBAN-002100-52-7Availablebenzaldehyde
IBAN-00322710-00-53-(methyl(pentyl)amino)propanoic acid hydrochloride
IBAN-00425468-43-3(E)-N-benzylidenepentan-1-amine
IBAN-00577223-58-6N-benzyl-N-methylpentan-1-amine
IBAN-00625419-06-1N-methylpentan-1-amine
IBAN-00796-33-3methyl acrylate
IBAN-008744266-99-7 methyl 3-[methyl(pentyl)amino]propanoate
IBAN-009287395-61-33-(methyl(pentyl)amino)propanoic acid
OptimisedRoute 2Steps 4 · Total yield 315.60 g
IBAN-00322710-00-5IBAN-00625419-06-1IBAN-00796-33-3IBAN-008744266-99-7IBAN-010625120-81-2IBAN-011105-58-8API · Ibandronate Sodium Hydrate
CodeCAS No.Intermediate
IBAN-00322710-00-53-(methyl(pentyl)amino)propanoic acid hydrochloride
IBAN-00625419-06-1N-methylpentan-1-amine
IBAN-00796-33-3methyl acrylate
IBAN-008744266-99-7 methyl 3-[methyl(pentyl)amino]propanoate
IBAN-010625120-81-23-[methyl(pentyl)amino]propanoic acid;hydrochloride
IBAN-011105-58-8diethyl carbonate
OptimisedRoute 3Steps 5 · Total yield 53.33 g
IBAN-00577223-58-6IBAN-00625419-06-1IBAN-008744266-99-7IBAN-010625120-81-2IBAN-012103-67-3IBAN-013110-53-2IBAN-0143395-91-3API · Ibandronate Sodium Hydrate
CodeCAS No.Intermediate
IBAN-00577223-58-6N-benzyl-N-methylpentan-1-amine
IBAN-00625419-06-1N-methylpentan-1-amine
IBAN-008744266-99-7 methyl 3-[methyl(pentyl)amino]propanoate
IBAN-010625120-81-23-[methyl(pentyl)amino]propanoic acid;hydrochloride
IBAN-012103-67-3N-methyl-1-phenylmethanamine
IBAN-013110-53-21-bromopentane
IBAN-0143395-91-3methyl 3-bromopropanoate
OptimisedRoute 4Steps 5 · Total yield /
IBAN-009287395-61-3IBAN-013110-53-2IBAN-015693-05-0IBAN-016919491-64-8IBAN-017114084-78-5API · Ibandronate Sodium Hydrate
CodeCAS No.Intermediate
IBAN-009287395-61-33-(methyl(pentyl)amino)propanoic acid
IBAN-013110-53-21-bromopentane
IBAN-015693-05-0 3-(methylamino)propanenitrile
IBAN-016919491-64-8methyl 3-(methyl(pentyl)amino)propanoate
IBAN-017114084-78-5[1-hydroxy-3-[methyl(pentyl)amino]-1-phosphonopropyl]phosphonic acid
OptimisedRoute 5Steps 3 · Total yield 126.00 g
IBAN-013110-53-2IBAN-01879-10-7IBAN-01924549-12-0IBAN-020128202-57-3API · Ibandronate Sodium Hydrate
CodeCAS No.Intermediate
IBAN-013110-53-21-bromopentane
IBAN-01879-10-7acrylic acid
IBAN-01924549-12-0methyl 3-(methylamino)propanoate
IBAN-020128202-57-3[1-hydroxy-3-(methylamino)-1-phosphonopropyl]phosphonic acid

Frequently asked questions

What are the approved indications of Ibandronate Sodium Hydrate?

Approved indications include: Osteoporosis, Postmenopausal osteoporosis, Hypercalcaemia, Bone injury, Breast cancer, Metastatic cancer.

When does the Ibandronate Sodium Hydrate patent expire?

No public expiry year is available for Ibandronate Sodium Hydrate yet; this page updates once verified.

How many synthesis routes are recorded for Ibandronate Sodium Hydrate?

5 synthesis routes are recorded; the shortest is 3 steps with 126.00 g total yield. Intermediates in each route carry codes and CAS numbers.

Where can I buy Ibandronate Sodium Hydrate intermediates?

1 intermediate CAS of Ibandronate Sodium Hydrate are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.

How do I get a quote for Ibandronate Sodium Hydrate intermediates?

Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.

Source: cross-verified data (structured fields only) · 2026-09-29