Clotrimazole

Tier C — Watch / trade

Clotrimazole

MSD (Merck Sharp & Dohme)

Originator

First approval

Expiry (public)

No sales data

Peak sales

Small molecule

Type

Targets：CYP51A1

Brand：Correcta, Canesten, Gyne-Lotrimin 3, Mycelex Troche, Trivagizole 3, Lotrimin

Indications (approved)：Candidiasis, Vulvovaginal candidiasis, Aspergillus infection, Otitis externa, Pruritus

Regional status

Approved

1975-02-03

No progress

2008-09-01

China

Approved

Japan

Factories producing this API1

Factories registered as producing this API in our sourcing network (RFQ records + product master), sorted by RFQ activity; the snapshot carries no cost or customer data.

1 producing factories on file — sign in to view the named list (factory details are not shown to guests).

Synthetic routes & intermediates4 routes

Originator routes × 0Optimised (non-patent) × 4Process routes × 0

Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.

OptimisedRoute 1Steps 3 · Total yield /

(I)70353-1-a95-49-8(II)70353-1-a2136-89-2(III)70353-1-a71-43-2(IV)70353-1-a42074-68-0(IX)70353-1-a100-58-3(V)70353-1-a288-32-4(VI)70353-1-a5162-03-8(VII)70353-1-a3509-85-1(VIII)70353-1-a66774-02-5(X)70353-1-a42879-93-6API · Clotrimazole

Code	CAS No.	Intermediate
(I)70353-1-a	95-49-8	1-Chloranyl-2-methylbenzene
(II)70353-1-a	2136-89-2	1-Chloro-2-(trichloromethyl)benzene
(III)70353-1-a	71-43-2	Benzene
(IV)70353-1-a	42074-68-0	(2-Chlorophenyl) diphenyl chloromethane
(IX)70353-1-a	100-58-3	Bromo(phenyl)magnesium
(V)70353-1-a	288-32-4	1,3-Diaza-2,4-cyclopentadiene
(VI)70353-1-a	5162-03-8	(2-Chlorophenyl)(phenyl)methanone
(VII)70353-1-a	3509-85-1	(2-Chlorophenyl)phenyldichloromethane
(VIII)70353-1-a	66774-02-5	(2-Chlorophenyl)-diphenylmethanol
(X)70353-1-a	42879-93-6	Silver imidazolate

OptimisedRoute 2Steps 6 · Total yield /

(I)70353-2-a89479-33-4(II)70353-2-a40681-65-0(III)70353-2-a68234-52-6(IV)70353-2-a71-43-2(V)70353-2-a68234-53-7(VI)70353-2-a108-86-1(VII)70353-2-a68234-54-8(VIII)70353-2-a68234-55-9(IX)70353-2-a288-32-4(X)70353-2-a53682-83-0API · Clotrimazole

Code	CAS No.	Intermediate
(I)70353-2-a	89479-33-4	(2-Chlorophenyl)(iodo)magnesium
(II)70353-2-a	40681-65-0	(14C)-2-Chlorobenzoic acid
(III)70353-2-a	68234-52-6	(14C)-2-Chlorobenzoyl chloride
(IV)70353-2-a	71-43-2	Benzene
(V)70353-2-a	68234-53-7	(14C)-2-Chlorobenzophenone
(VI)70353-2-a	108-86-1	Bromanylbenzene
(VII)70353-2-a	68234-54-8	(14C)-(2-Chlorophenyl)diphenylmethanol
(VIII)70353-2-a	68234-55-9	(14C)-1-(2-Chlorophenyl)-1,1-diphenylmethyl chloride
(IX)70353-2-a	288-32-4	1,3-Diaza-2,4-cyclopentadiene
(X)70353-2-a	53682-83-0	(14C)-1-[1-(2-Chlorophenyl)-1,1-diphenylmethyl]-1H-imidazole

OptimisedRoute 3Steps 1 · Total yield /

(I)70353-3-a17849-38-6(II)70353-3-a873-32-5API · Clotrimazole

Code	CAS No.	Intermediate
(I)70353-3-a	17849-38-6	1-(2-Chlorophenyl)methanol
(II)70353-3-a	873-32-5	1-Chloro-2-cyanobenzene

OptimisedRoute 4Steps 1 · Total yield /

(I)70353-4-a42074-68-0(II)70353-4-a288-32-4API · Clotrimazole

Code	CAS No.	Intermediate
(I)70353-4-a	42074-68-0	(2-Chlorophenyl) diphenyl chloromethane
(II)70353-4-a	288-32-4	1,3-Diaza-2,4-cyclopentadiene

Frequently asked questions

What are the approved indications of Clotrimazole?

Approved indications include: Candidiasis, Vulvovaginal candidiasis, Aspergillus infection, Otitis externa, Pruritus.

When does the Clotrimazole patent expire?

No public expiry year is available for Clotrimazole yet; this page updates once verified.

How many synthesis routes are recorded for Clotrimazole?

4 synthesis routes are recorded; the shortest is 1 steps with / total yield. Intermediates in each route carry codes and CAS numbers.

Where can I buy Clotrimazole intermediates?

All intermediates in Clotrimazole routes have CAS profiles — you can submit an RFQ per CAS and it enters the Unibest matching pool.

How do I get a quote for Clotrimazole intermediates?

Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.

Source: cross-verified data (structured fields only) · 2026-09-29