Amlodipine Besylate/Tadalafil

Tier C — Watch / trade

Hanmi Pharmaceutical Co., Ltd.

Originator

2016

First approval

Expiry (public)

No sales data

Peak sales

Small molecule

Type

Targets：VDCCs, PDE5A

Brand：Amorafil

Indications (approved)：Erectile dysfunction, Hypertension

Regional status

China

Japan

Factories producing this API12

Factories registered as producing this API in our sourcing network (RFQ records + product master), sorted by RFQ activity; the snapshot carries no cost or customer data.

12 producing factories on file — sign in to view the named list (factory details are not shown to guests).

Synthetic routes & intermediates5 routes

Originator routes × 0Optimised (non-patent) × 5Process routes × 0

Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.

OptimisedRoute 1Steps 5 · Total yield 0.19 g

TADA-00154-12-6TADA-002120-57-0TADA-003406938-39-4TADA-004474668-76-3TADA-005171596-41-1TADA-006171489-59-1API · Amlodipine Besylate/Tadalafil

Code	CAS No.	Intermediate
TADA-001	54-12-6	tryptophan
TADA-002	120-57-0	benzo[d][1,3]dioxole-5-carbaldehyde
TADA-003	406938-39-4	1-(benzo[d][1,3]dioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic acid
TADA-004	474668-76-3	(1R,3R)-1-(benzo[d][1,3]dioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic acid hydrochloride
TADA-005	171596-41-1	methyl (1R,3R)-1-(benzo[d][1,3]dioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate
TADA-006	171489-59-1	methyl (1R,3R)-1-(benzo[d][1,3]dioxol-5-yl)-2-(2-chloroacetyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate

OptimisedRoute 2Steps 4 · Total yield 86 g

TADA-00154-12-6TADA-002120-57-0TADA-007103222-66-8TADA-00813515-93-0TADA-0091542950-66-2TADA-0101542950-70-8API · Amlodipine Besylate/Tadalafil

Code	CAS No.	Intermediate
TADA-001	54-12-6	tryptophan
TADA-002	120-57-0	benzo[d][1,3]dioxole-5-carbaldehyde
TADA-007	103222-66-8	tryptophanoyl chloride hydrochloride
TADA-008	13515-93-0	methyl 2-(methyl-l2-azaneyl)acetate hydrochloride
TADA-009	1542950-66-2	methyl N-methyl-N-tryptophylglycinate hydrochloride
TADA-010	1542950-70-8	methyl ((1R,3R)-1-(benzo[d][1,3]dioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carbonyl)(methyl)carbamate

OptimisedRoute 3Steps 6 · Total yield /

TADA-006171489-59-1TADA-0117524-52-9TADA-012171596-43-3TADA-013—TADA-014171596-42-2TADA-0151609374-53-9API · Amlodipine Besylate/Tadalafil

Code	CAS No.	Intermediate
TADA-006	171489-59-1	methyl (1R,3R)-1-(benzo[d][1,3]dioxol-5-yl)-2-(2-chloroacetyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate
TADA-011	7524-52-9	methyl L-tryptophanate hydrochloride
TADA-012	171596-43-3	methyl (1S,3S)-1-(benzo[d][1,3]dioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate
TADA-013	-	methyl (1S,3R)-1-(benzo[d][1,3]dioxol-5-yl)-2-(4-nitrobenzyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate
TADA-014	171596-42-2	methyl (1S,3R)-1-(benzo[d][1,3]dioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate
TADA-015	1609374-53-9	methyl (1S,3R)-1-(benzo[d][1,3]dioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate hydrochloride

OptimisedRoute 4Steps 1 · Total yield /

TADA-002120-57-0TADA-004474668-76-3TADA-016153-94-6API · Amlodipine Besylate/Tadalafil

Code	CAS No.	Intermediate
TADA-002	120-57-0	benzo[d][1,3]dioxole-5-carbaldehyde
TADA-004	474668-76-3	(1R,3R)-1-(benzo[d][1,3]dioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic acid hydrochloride
TADA-016	153-94-6	D-tryptophan

OptimisedRoute 5Steps 3 · Total yield /

TADA-002120-57-0TADA-005171596-41-1TADA-006171489-59-1TADA-01722032-65-1API · Amlodipine Besylate/Tadalafil

Code	CAS No.	Intermediate
TADA-002	120-57-0	benzo[d][1,3]dioxole-5-carbaldehyde
TADA-005	171596-41-1	methyl (1R,3R)-1-(benzo[d][1,3]dioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate
TADA-006	171489-59-1	methyl (1R,3R)-1-(benzo[d][1,3]dioxol-5-yl)-2-(2-chloroacetyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate
TADA-017	22032-65-1	methyl D-tryptophanate

Frequently asked questions

What are the approved indications of Amlodipine Besylate/Tadalafil?

Approved indications include: Erectile dysfunction, Hypertension.

When does the Amlodipine Besylate/Tadalafil patent expire?

No public expiry year is available for Amlodipine Besylate/Tadalafil yet; this page updates once verified.

How many synthesis routes are recorded for Amlodipine Besylate/Tadalafil?

5 synthesis routes are recorded; the shortest is 1 steps with / total yield. Intermediates in each route carry codes and CAS numbers.

Where can I buy Amlodipine Besylate/Tadalafil intermediates?

All intermediates in Amlodipine Besylate/Tadalafil routes have CAS profiles — you can submit an RFQ per CAS and it enters the Unibest matching pool.

How do I get a quote for Amlodipine Besylate/Tadalafil intermediates?

Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.

Source: cross-verified data (structured fields only) · 2026-09-29