Nebivolol Hydrochloride

Tier C — Watch / trade

Johnson & Johnson Innovative Medicine

Originator

1997

First approval

Expiry (public)

$0.65B ▲

Peak sales

Small molecule

Type

Targets：ADRB1

Brand：Lobivon, Nebilox, Solistar, Nebilet, Bystolic

Indications (approved)：Hypertension

Regional status

Approved

2007-12-17

Approved

1997-01-01

China

Phase III

2014-12-30

Japan

Synthetic routes & intermediates1 routes

Originator routes × 1Optimised (non-patent) × 0Process routes × 0

Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.

OriginatorRoute 1Steps 8 · Total yield /

NEBI-00199199-59-4NEBI-00299199-60-7NEBI-00399199-61-8NEBI-00499199-62-9NEBI-005409346-73-2NEBI-00699199-90-3NEBI-00799199-91-4NEBI-008929706-85-4API · Nebivolol Hydrochloride

Code	CAS No.	Intermediate
NEBI-001	99199-59-4 Available	6-fluoro-4-oxo-4H-chromene-2-carboxylic acid
NEBI-002	99199-60-7 Available	6-fluorochromane-2-carboxylic acid
NEBI-003	99199-61-8 Available	ethyl 6-fluorochromane-2-carboxylate
NEBI-004	99199-62-9 Available	(6-fluorochroman-2-yl)methanol
NEBI-005	409346-73-2 Available	6-fluorochromane-2-carbaldehyde
NEBI-006	99199-90-3 Available	6-fluoro-2-(oxiran-2-yl)chromane
NEBI-007	99199-91-4 Available	2-(benzylamino)-1-(6-fluorochroman-2-yl)ethan-1-ol
NEBI-008	929706-85-4 Available	2,2'-(benzylazanediyl)bis(1-(6-fluorochroman-2-yl)ethan-1-ol)

Frequently asked questions

What are the approved indications of Nebivolol Hydrochloride?

Approved indications include: Hypertension.

When does the Nebivolol Hydrochloride patent expire?

No public expiry year is available for Nebivolol Hydrochloride yet; this page updates once verified.

How many synthesis routes are recorded for Nebivolol Hydrochloride?

1 synthesis routes are recorded; the shortest is 8 steps with / total yield. Intermediates in each route carry codes and CAS numbers.

Where can I buy Nebivolol Hydrochloride intermediates?

8 intermediate CAS of Nebivolol Hydrochloride are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.

How do I get a quote for Nebivolol Hydrochloride intermediates?

Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.

Source: cross-verified data (structured fields only) · 2026-09-29