Picropodophyllin
Tier C — Watch / tradePicropodophyllin
Targets：IGF1R
Indications (approved)：Non-small cell lung cancer, 星形细胞瘤, 人乳头瘤病毒感染, Glioblastoma, 少突神经胶质瘤, 神经胶质肉瘤, 室管膜瘤
Regional status
Synthetic routes & intermediates1 routes
Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.
| Code | CAS No. | Intermediate |
|---|---|---|
| PICR-001 | 107402-01-7 | methyl 7-methylnaphtho[2,3-d][1,3]dioxole-6-carboxylate |
| PICR-002 | 117097-35-5 | methyl 7-(bromomethyl)naphtho[2,3-d][1,3]dioxole-6-carboxylate |
| PICR-003 | - | methyl 7-((allyloxy)methyl)naphtho[2,3-d][1,3]dioxole-6-carboxylate |
| PICR-004 | 103993-80-2 | (2R,3R)-3-amino-4-methoxybutan-2-ol |
| PICR-005 | 117097-39-9 | (4R,5R)-2-(7-((allyloxy)methyl)naphtho[2,3-d][1,3]dioxol-6-yl)-4-(methoxymethyl)-5-methyl-4,5-dihydrooxazole |
| PICR-006 | 117097-42-4 | (7-((4R,5R)-4-(methoxymethyl)-5-methyl-4,5-dihydrooxazol-2-yl)naphtho[2,3-d][1,3]dioxol-6-yl)methanol |
| PICR-007 | 117097-43-5 | (4R,5R)-2-(7-(((tert-butyldimethylsilyl)oxy)methyl)naphtho[2,3-d][1,3]dioxol-6-yl)-4-(methoxymethyl)-5-methyl-4,5-dihydrooxazole |
| PICR-008 | 2675-79-8 | 5-bromo-1,2,3-trimethoxybenzene |
| PICR-009 | - | (4R,5R)-2-((5R)-7-(((tert-butyldimethylsilyl)oxy)methyl)-5-(3,4,5-trimethoxyphenyl)-5,6-dihydronaphtho[2,3-d][1,3]dioxol-6-yl)-4-(methoxymethyl)-5-methyl-4,5-dihydrooxazole |
| PICR-010 | - | (2R,3R)-4-acetamido-3-(methoxymethyl)butan-2-yl (5R)-7-(acetoxymethyl)-5-(3,4,5-trimethoxyphenyl)-5,6-dihydronaphtho[2,3-d][1,3]dioxole-6-carboxylate |
| PICR-011 | 477-52-1 | (R)-5-(3,4,5-trimethoxyphenyl)-5,9-dihydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(8H)-one |
| PICR-012 | 117097-47-9 | methyl (5R,6S)-7-(((tert-butyldimethylsilyl)oxy)methyl)-5-(3,4,5-trimethoxyphenyl)-5,6-dihydronaphtho[2,3-d][1,3]dioxole-6-carboxylate |
| PICR-013 | 117097-48-0 | methyl (5R,6R,7R,8S)-7-bromo-7-(((tert-butyldimethylsilyl)oxy)methyl)-8-hydroxy-5-(3,4,5-trimethoxyphenyl)-5,6,7,8-tetrahydronaphtho[2,3-d][1,3]dioxole-6-carboxylate |
| PICR-014 | 117097-49-1 | methyl (5R,6S,7S,8R)-7-(((tert-butyldimethylsilyl)oxy)methyl)-8-hydroxy-5-(3,4,5-trimethoxyphenyl)-5,6,7,8-tetrahydronaphtho[2,3-d][1,3]dioxole-6-carboxylate |
| PICR-015 | 117097-50-4 | methyl (5R,6S,7S)-7-(((tert-butyldimethylsilyl)oxy)methyl)-8-oxo-5-(3,4,5-trimethoxyphenyl)-5,6,7,8-tetrahydronaphtho[2,3-d][1,3]dioxole-6-carboxylate |
| PICR-016 | 64897-39-8 | (5aS,8aS,9R)-5a-(hydroxymethyl)-9-(3,4,5-trimethoxyphenyl)-5a,6,8a,9-tetrahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxole-5,8-dione |
| PICR-017 | 477-48-5 | (5aR,8aS,9R)-9-(3,4,5-trimethoxyphenyl)-5a,6,8a,9-tetrahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxole-5,8-dione |
Frequently asked questions
What are the approved indications of Picropodophyllin?
Approved indications include: Non-small cell lung cancer, 星形细胞瘤, 人乳头瘤病毒感染, Glioblastoma, 少突神经胶质瘤, 神经胶质肉瘤, 室管膜瘤.
When does the Picropodophyllin patent expire?
No public expiry year is available for Picropodophyllin yet; this page updates once verified.
How many synthesis routes are recorded for Picropodophyllin?
1 synthesis routes are recorded; the shortest is 15 steps with 10.5 mg total yield. Intermediates in each route carry codes and CAS numbers.
Where can I buy Picropodophyllin intermediates?
All intermediates in Picropodophyllin routes have CAS profiles — you can submit an RFQ per CAS and it enters the Unibest matching pool.
How do I get a quote for Picropodophyllin intermediates?
Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.
Source: cross-verified data (structured fields only) · 2026-10-13