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Artesunate/Pyronaridine Phosphate

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Artesunate/Pyronaridine Phosphate

Shin Poong Pharmaceutical Co., Ltd.
Originator
2012
First approval
-
Expiry (public)
No sales data
Peak sales
Small molecule
Type

Targets:ATP2A2, ATP2A1

Brand:Pyramax

Indications (approved):Plasmodium infection

Regional status

US
-
EU
Phase III
2021-10-18
China
-
Japan
-

Factories producing this API12

Factories registered as producing this API in our sourcing network (RFQ records + product master), sorted by RFQ activity; the snapshot carries no cost or customer data.

12 producing factories on file — sign in to view the named list (factory details are not shown to guests).

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Synthetic routes & intermediates3 routes

Originator routes × 0Optimised (non-patent) × 3Process routes × 0

Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.

OptimisedRoute 1Steps 3 · Total yield /
(I)91299-1-a85031-59-0(II)91299-1-a—(III)91299-1-a131175-87-6(IV)91299-1-a108-30-5API · Artesunate/Pyronaridine Phosphate
CodeCAS No.Intermediate
(I)91299-1-a85031-59-0Dihydroartemisinic acid
(II)91299-1-a-(1R,4S,5R,8S,9R,12S,13R)-1,5,9-Trimethyl-11,14,15,16-tetraoxatetracyclo[10.3.1.04,13.08,13]hexadecan-10-one
(III)91299-1-a131175-87-6(1R,4S,5R,8S,9R,12R,13R)-1,5,9-Trimethyl-11,14,15,16-tetraoxatetracyclo[10.3.1.04,13.08,13]hexadecan-10-ol
(IV)91299-1-a108-30-52,5-Dioxotetrahydrofuran
OptimisedRoute 2Steps 6 · Total yield /
(V)91299-1-b433-19-2(VI)91299-1-b2375-96-4(VII)91299-1-b71597-85-8(VIII)91299-1-b2544370-97-8(IX)91299-1-b2544370-99-0(X)91299-1-b2544371-02-8(XI)91299-1-b4334-88-7(XII)91299-1-b2544371-04-0(XIII)91299-1-b2544371-10-8API · Artesunate/Pyronaridine Phosphate
CodeCAS No.Intermediate
(V)91299-1-b433-19-21,4-Bis(trifluoromethyl)benzene
(VI)91299-1-b2375-96-41,4-Dibromo-2,5-bis(trifluoromethyl)benzene
(VII)91299-1-b71597-85-8(4-Hydroxyphenyl)boronic acid
(VIII)91299-1-b2544370-97-82(2),2(5)-Bis(trifluoromethyl)[1(1),2(1):2(4),3(1)-terphenyl]-1(4),3(4)-diol
(IX)91299-1-b2544370-99-01(3),1(5),3(3),3(5)-Tetrabromo-2(2),2(5)-bis(trifluoromethyl)[1(1),2(1):2(4),3(1)-terphenyl]-1(4),3(4)-diol
(X)91299-1-b2544371-02-81(3),1(5),3(3),3(5)-Tetrabromo-1(4),3(4)-dimethoxy-2(2),2(5)-bis(trifluoromethyl)-1(1),2(1):2(4),3(1)-terphenyl
(XI)91299-1-b4334-88-74-(Ethoxycarbonyl)phenylboronic acid
(XII)91299-1-b2544371-04-0Ethyl 4-[5-[4-[3,5-bis(4-ethoxycarbonylphenyl)-4-methoxy-phenyl]-2,5-bis(trifluoromethyl)phenyl]-3-(4-ethoxycarbonylphenyl)-2-methoxy-phenyl]benzoate
(XIII)91299-1-b2544371-10-84-[5-[4-[3,5-Bis(4-carboxyphenyl)-4-methoxy-phenyl]-2,5-bis(trifluoromethyl)phenyl]-3-(4-carboxyphenyl)-2-methoxy-phenyl]benzoic acid
OptimisedRoute 3Steps 1 · Total yield /
(XIV)91299-1-c—(XV)91299-1-c1802-30-8(XVI)91299-1-c258334-13-3API · Artesunate/Pyronaridine Phosphate
CodeCAS No.Intermediate
(XIV)91299-1-c-cis-Dichloridoruthenium 2,2'-bipyridine (1/2)
(XV)91299-1-c1802-30-82,2'-Bipyridine-5,5'-dicarboxylic acid
(XVI)91299-1-c258334-13-3[2,2'-Bipyridine]-5,5'-dicarboxylic acid bis(2,2'-bipyridine) ruthenium(2+) dichloride

Frequently asked questions

What are the approved indications of Artesunate/Pyronaridine Phosphate?

Approved indications include: Plasmodium infection.

When does the Artesunate/Pyronaridine Phosphate patent expire?

No public expiry year is available for Artesunate/Pyronaridine Phosphate yet; this page updates once verified.

How many synthesis routes are recorded for Artesunate/Pyronaridine Phosphate?

3 synthesis routes are recorded; the shortest is 1 steps with / total yield. Intermediates in each route carry codes and CAS numbers.

Where can I buy Artesunate/Pyronaridine Phosphate intermediates?

All intermediates in Artesunate/Pyronaridine Phosphate routes have CAS profiles — you can submit an RFQ per CAS and it enters the Unibest matching pool.

How do I get a quote for Artesunate/Pyronaridine Phosphate intermediates?

Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.

Source: cross-verified data (structured fields only) · 2026-09-29