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Tazobactam Sodium/Ceftolozane
Tier C — Watch / tradeTazobactam Sodium/Ceftolozane
MSD (Merck Sharp & Dohme)
Originator
2014
First approval
-
Expiry (public)
$0.31B ▲
Peak sales
Small molecule
Type
Targets：Beta Lactamase, PBP1b, PBP3
Brand：Zerbaxa
Indications (approved)：Intra-abdominal infection, Ventilator-associated pneumonia, Urinary tract infection, Community-acquired bacterial pneumonia, Pyelonephritis, Hospital-acquired pneumonia, Bacterial pneumonia, Cystitis
Regional status
US
Approved
2014-12-19
EU
Approved
2015-09-18
China
Approved
2025-02-08
Japan
Approved
2019-01-08
Factories producing this API9
Factories registered as producing this API in our sourcing network (RFQ records + product master), sorted by RFQ activity; the snapshot carries no cost or customer data.
9 producing factories on file — sign in to view the named list (factory details are not shown to guests).
Sign in to view factories →Synthetic routes & intermediates13 routes
Originator routes × 0Optimised (non-patent) × 12Process routes × 1
Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.
OptimisedRoute 1Steps 8 · Total yield 181.68g(Tazobactam (Free))
Tazobactam Sodium-00187579-78-0Tazobactam Sodium-002149-30-4Tazobactam Sodium-00387579-79-1Tazobactam Sodium-00485573-73-5Tazobactam Sodium-00589051-47-8Tazobactam Sodium-00689051-49-0Tazobactam Sodium-0071066-54-2Tazobactam Sodium-008—Tazobactam Sodium-00989789-07-1Tazobactam Sodium-01074-86-2Tazobactam Sodium-011108-05-4Tazobactam Sodium-01289786-04-9API · Tazobactam Sodium/Ceftolozane
| Code | CAS No. | Intermediate |
|---|---|---|
| Tazobactam Sodium-001 | 87579-78-0Available | (2S,5R)-2beta-[(Benzhydryloxy)carbonyl]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane4-oxide |
| Tazobactam Sodium-002 | 149-30-4Available | 1,3-Benzothiazole-2-thiol |
| Tazobactam Sodium-003 | 87579-79-1Available | (2R)-2-[(2R)-2-[(Benzothiazol-2-yl)dithio]-4-oxoazetidin-1-yl]-3-methyl-3-butenoic acid benzhydryl ester |
| Tazobactam Sodium-004 | 85573-73-5Available | (2S-(2alpha,3beta,5alpha))-3-(Chloromethyl)-3-methyl-7-oxo-4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid diphenylmethyl ester |
| Tazobactam Sodium-005 | 89051-47-8Available | Benzhydryl (2S,3S,5R)-3-(azidomethyl)-3-methyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate |
| Tazobactam Sodium-006 | 89051-49-0Available | Benzhydryl (2S,3S,5R)-3-(azidomethyl)-3-methyl-4,4,7-trioxo-4lambda6-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate |
| Tazobactam Sodium-007 | 1066-54-2Available | 1-Trimethylsilylethyne |
| Tazobactam Sodium-008 | - | Benzhydryl 2a-methyl-2beta-(4-trimethylsilyl-1,2,3-triazol-1 ylmethyl)penam-3a-carboxylate-1,1-dioxide |
| Tazobactam Sodium-009 | 89789-07-1Available | Benzhydryl (2S,3S,5R)-3-((1H-1,2,3-triazol-1-yl)methyl)-3-methyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate 4,4-dioxide |
| Tazobactam Sodium-010 | 74-86-2Available | Acetylene |
| Tazobactam Sodium-011 | 108-05-4Available | 1-Acetoxyethylene |
| Tazobactam Sodium-012 | 89786-04-9Available | (2S,3S,5R)-3-Methyl-4,4,7-trioxo-3-(triazol-1-ylmethyl)-4lambda6-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid |
OptimisedRoute 3Steps 14 · Total yield 17g(Tazobactam Sodium-029)
Tazobactam Sodium-021551-16-6Tazobactam Sodium-02224158-88-1Tazobactam Sodium-02375527-84-3Tazobactam Sodium-024113891-01-3Tazobactam Sodium-00187579-78-0Tazobactam Sodium-02569126-86-9Tazobactam Sodium-02613257-88-0Tazobactam Sodium-027288-36-8Tazobactam Sodium-028120241-79-4Tazobactam Sodium-020125949-72-6Tazobactam Sodium-029—Tazobactam Sodium-03079703-02-9Tazobactam Sodium-0315350-57-2Tazobactam Sodium-03287-53-6Tazobactam Sodium-03379702-81-1Tazobactam Sodium-03473968-83-9Tazobactam Sodium-002149-30-4Tazobactam Sodium-00387579-79-1Tazobactam Sodium-03572118-49-1Tazobactam Sodium-03689051-48-9Tazobactam Sodium-00485573-73-5Tazobactam Sodium-037—API · Tazobactam Sodium/Ceftolozane
| Code | CAS No. | Intermediate |
|---|---|---|
| Tazobactam Sodium-021 | 551-16-6Available | (+)-6-Aminopenicillanic acid |
| Tazobactam Sodium-022 | 24158-88-1Available | (2S,5R)-6,6-Dibromo-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid |
| Tazobactam Sodium-023 | 75527-84-3Available | Diphenylmethyl (2S,5R)-6,6-dibromo-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate |
| Tazobactam Sodium-024 | 113891-01-3Available | Diphenylmethyl (2S,5R)-6,6-dibromo-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate 4-oxide |
| Tazobactam Sodium-001 | 87579-78-0Available | (2S,5R)-2beta-[(Benzhydryloxy)carbonyl]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane4-oxide |
| Tazobactam Sodium-025 | 69126-86-9Available | Methyl (2S,5R)-3,3-dimethyl-4,7-dioxo-4lambda4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate |
| Tazobactam Sodium-026 | 13257-88-0Available | 1-(Trimethylsilyl)-1,2,3-triazole |
| Tazobactam Sodium-027 | 288-36-8Available | 1,2,3-Triazole |
| Tazobactam Sodium-028 | 120241-79-4Available | 3-(1,2,3-Triazol-4-yl)pyridine |
| Tazobactam Sodium-020 | 125949-72-6Available | (2S,3S,5R)-2-Methyl-2-(1H-1,2,3-triazol-1-ylmethyl)penam-3-carboxylic acid diphenylmethyl ester |
| Tazobactam Sodium-029 | - | Methyl (2S,3S,5R)-3-methyl-7-oxo-3-[(1H-1,2,3-triazol-1-yl)methyl]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate |
| Tazobactam Sodium-030 | 79703-02-9Available | (2S,4R,6S)-6-Bromo-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid 4-oxide |
| Tazobactam Sodium-031 | 5350-57-2Available | (Diphenylmethylidene)hydrazine |
| Tazobactam Sodium-032 | 87-53-6Available | (2S,5R)-3,3-Dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid |
| Tazobactam Sodium-033 | 79702-81-1Available | (2S,5R)-3,3-Dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid 4-oxide |
| Tazobactam Sodium-034 | 73968-83-9Available | Benzhydryl (2S,5R)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate |
| Tazobactam Sodium-002 | 149-30-4Available | 1,3-Benzothiazole-2-thiol |
| Tazobactam Sodium-003 | 87579-79-1Available | (2R)-2-[(2R)-2-[(Benzothiazol-2-yl)dithio]-4-oxoazetidin-1-yl]-3-methyl-3-butenoic acid benzhydryl ester |
| Tazobactam Sodium-035 | 72118-49-1Available | Methyl (2R)-2-[(2R)-2-[(1,3-benzothiazol-2-yl)disulfanyl]-4-oxoazetidin-1-yl]-3-methylbut-3-enoate |
| Tazobactam Sodium-036 | 89051-48-9Available | Diphenylmethyl (2S,3R,5R)-3-(bromomethyl)-3-methyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate |
| Tazobactam Sodium-004 | 85573-73-5Available | (2S-(2alpha,3beta,5alpha))-3-(Chloromethyl)-3-methyl-7-oxo-4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid diphenylmethyl ester |
| Tazobactam Sodium-037 | - | Methyl (2S,3R,5R)-3-(chloromethyl)-3-methyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate |
OptimisedRoute 4Steps 7 · Total yield 5g(Tazobactam (Free))
Tazobactam Sodium-027288-36-8Tazobactam Sodium-038—Tazobactam Sodium-020125949-72-6Tazobactam Sodium-029—Tazobactam Sodium-00989789-07-1Tazobactam Sodium-039—Tazobactam Sodium-01289786-04-9Tazobactam Sodium-03689051-48-9Tazobactam Sodium-040—Tazobactam Sodium-0412775432-22-7Tazobactam Sodium-042—API · Tazobactam Sodium/Ceftolozane
| Code | CAS No. | Intermediate |
|---|---|---|
| Tazobactam Sodium-027 | 288-36-8Available | 1,2,3-Triazole |
| Tazobactam Sodium-038 | - | Silver(1+) 1,2,3-triazol-1-ide |
| Tazobactam Sodium-020 | 125949-72-6Available | (2S,3S,5R)-2-Methyl-2-(1H-1,2,3-triazol-1-ylmethyl)penam-3-carboxylic acid diphenylmethyl ester |
| Tazobactam Sodium-029 | - | Methyl (2S,3S,5R)-3-methyl-7-oxo-3-[(1H-1,2,3-triazol-1-yl)methyl]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate |
| Tazobactam Sodium-009 | 89789-07-1Available | Benzhydryl (2S,3S,5R)-3-((1H-1,2,3-triazol-1-yl)methyl)-3-methyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate 4,4-dioxide |
| Tazobactam Sodium-039 | - | Methyl (2S,3S,5R)-3-methyl-4,4,7-trioxo-3-[(1H-1,2,3-triazol-1-yl)methyl]-4lambda6-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate |
| Tazobactam Sodium-012 | 89786-04-9Available | (2S,3S,5R)-3-Methyl-4,4,7-trioxo-3-(triazol-1-ylmethyl)-4lambda6-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid |
| Tazobactam Sodium-036 | 89051-48-9Available | Diphenylmethyl (2S,3R,5R)-3-(bromomethyl)-3-methyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate |
| Tazobactam Sodium-040 | - | Diphenylmethyl (2S,3R,4R,5R)-3-(bromomethyl)-3-methyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate 4-oxide |
| Tazobactam Sodium-041 | 2775432-22-7Available | (Z)-Ethene-1,2-diamine hydrogen chloride |
| Tazobactam Sodium-042 | - | Diphenylmethyl (2S,3S,4R,5R)-3-methyl-7-oxo-3-(1H-1,2,3-triazol-1-ylmethyl)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate 4-oxide |
OptimisedRoute 5Steps 15 · Total yield 4.6g(Tazobactam (Free))
Tazobactam Sodium-021551-16-6Tazobactam Sodium-04324138-28-1Tazobactam Sodium-03079703-02-9Tazobactam Sodium-0315350-57-2Tazobactam Sodium-044883-40-9Tazobactam Sodium-04580353-26-0Tazobactam Sodium-04674189-25-6Tazobactam Sodium-00187579-78-0Tazobactam Sodium-002149-30-4Tazobactam Sodium-00387579-79-1Tazobactam Sodium-00485573-73-5Tazobactam Sodium-047—Tazobactam Sodium-048—Tazobactam Sodium-00689051-49-0Tazobactam Sodium-049104893-87-0Tazobactam Sodium-00589051-47-8Tazobactam Sodium-01074-86-2Tazobactam Sodium-00989789-07-1Tazobactam Sodium-01289786-04-9API · Tazobactam Sodium/Ceftolozane
| Code | CAS No. | Intermediate |
|---|---|---|
| Tazobactam Sodium-021 | 551-16-6Available | (+)-6-Aminopenicillanic acid |
| Tazobactam Sodium-043 | 24138-28-1Available | (2S,5R,6S)-6-Bromo-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid |
| Tazobactam Sodium-030 | 79703-02-9Available | (2S,4R,6S)-6-Bromo-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid 4-oxide |
| Tazobactam Sodium-031 | 5350-57-2Available | (Diphenylmethylidene)hydrazine |
| Tazobactam Sodium-044 | 883-40-9Available | [Diazo(phenyl)methyl]benzene |
| Tazobactam Sodium-045 | 80353-26-0Available | (2S,5R,6S)-Benzhydryl 6-bromo-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate 4-oxide |
| Tazobactam Sodium-046 | 74189-25-6Available | Diphenylmethyl (2S,5R,6S)-6-bromo-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate |
| Tazobactam Sodium-001 | 87579-78-0Available | (2S,5R)-2beta-[(Benzhydryloxy)carbonyl]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane4-oxide |
| Tazobactam Sodium-002 | 149-30-4Available | 1,3-Benzothiazole-2-thiol |
| Tazobactam Sodium-003 | 87579-79-1Available | (2R)-2-[(2R)-2-[(Benzothiazol-2-yl)dithio]-4-oxoazetidin-1-yl]-3-methyl-3-butenoic acid benzhydryl ester |
| Tazobactam Sodium-004 | 85573-73-5Available | (2S-(2alpha,3beta,5alpha))-3-(Chloromethyl)-3-methyl-7-oxo-4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid diphenylmethyl ester |
| Tazobactam Sodium-047 | - | Diphenylmethyl (2S,3R,4R,5R)-3-(chloromethyl)-3-methyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate 4-oxide |
| Tazobactam Sodium-048 | - | Diphenylmethyl (2S,3S,4R,5R)-3-(azidomethyl)-3-methyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate 4-oxide |
| Tazobactam Sodium-006 | 89051-49-0Available | Benzhydryl (2S,3S,5R)-3-(azidomethyl)-3-methyl-4,4,7-trioxo-4lambda6-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate |
| Tazobactam Sodium-049 | 104893-87-0Available | Diphenylmethyl (2R,3S,6R)-3-azido-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]octane-2-carboxylate |
| Tazobactam Sodium-005 | 89051-47-8Available | Benzhydryl (2S,3S,5R)-3-(azidomethyl)-3-methyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate |
| Tazobactam Sodium-010 | 74-86-2Available | Acetylene |
| Tazobactam Sodium-009 | 89789-07-1Available | Benzhydryl (2S,3S,5R)-3-((1H-1,2,3-triazol-1-yl)methyl)-3-methyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate 4,4-dioxide |
| Tazobactam Sodium-012 | 89786-04-9Available | (2S,3S,5R)-3-Methyl-4,4,7-trioxo-3-(triazol-1-ylmethyl)-4lambda6-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid |
OptimisedRoute 6Steps 3 · Total yield 27.8g(Tazobactam Sodium-009)
Tazobactam Sodium-00485573-73-5Tazobactam Sodium-00689051-49-0Tazobactam Sodium-00989789-07-1Tazobactam Sodium-05085573-74-6Tazobactam Sodium-027288-36-8API · Tazobactam Sodium/Ceftolozane
| Code | CAS No. | Intermediate |
|---|---|---|
| Tazobactam Sodium-004 | 85573-73-5Available | (2S-(2alpha,3beta,5alpha))-3-(Chloromethyl)-3-methyl-7-oxo-4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid diphenylmethyl ester |
| Tazobactam Sodium-006 | 89051-49-0Available | Benzhydryl (2S,3S,5R)-3-(azidomethyl)-3-methyl-4,4,7-trioxo-4lambda6-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate |
| Tazobactam Sodium-009 | 89789-07-1Available | Benzhydryl (2S,3S,5R)-3-((1H-1,2,3-triazol-1-yl)methyl)-3-methyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate 4,4-dioxide |
| Tazobactam Sodium-050 | 85573-74-6Available | Diphenylmethyl (2S,3R,5R)-3-(chloromethyl)-3-methyl-4,4,7-trioxo-4lambda6-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate |
| Tazobactam Sodium-027 | 288-36-8Available | 1,2,3-Triazole |
OptimisedRoute 7Steps 5 · Total yield 167g(Tazobactam Sodium-001)
Tazobactam Sodium-021551-16-6Tazobactam Sodium-0315350-57-2Tazobactam Sodium-00187579-78-0Tazobactam Sodium-05199395-86-5Tazobactam Sodium-052134866-13-0Tazobactam Sodium-053134866-14-1API · Tazobactam Sodium/Ceftolozane
| Code | CAS No. | Intermediate |
|---|---|---|
| Tazobactam Sodium-021 | 551-16-6Available | (+)-6-Aminopenicillanic acid |
| Tazobactam Sodium-031 | 5350-57-2Available | (Diphenylmethylidene)hydrazine |
| Tazobactam Sodium-001 | 87579-78-0Available | (2S,5R)-2beta-[(Benzhydryloxy)carbonyl]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane4-oxide |
| Tazobactam Sodium-051 | 99395-86-5Available | Diphenylmethyl (2S,4R,5R,6R)-6-amino-3,3-dimethyl-4,7-dioxo-4lambda4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate |
| Tazobactam Sodium-052 | 134866-13-0Available | (2S,5R,6R)-6-[(tert-Butoxycarbonyl)amino]-3,3-dimethyl-4,7-dioxo-4lambda4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid |
| Tazobactam Sodium-053 | 134866-14-1Available | Diphenylmethyl (2S,5R,6R)-6-[(tert-butoxycarbonyl)amino]-3,3-dimethyl-4,7-dioxo-4lambda4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate |
OptimisedRoute 8Steps 1 · Total yield /
Tazobactam Sodium-05425232-41-1API · Tazobactam Sodium/Ceftolozane
| Code | CAS No. | Intermediate |
|---|---|---|
| Tazobactam Sodium-054 | 25232-41-1Available | alpha,omega-Dimethylpoly[1-(pyridin-4-yl)ethane-1,2-diyl] |
OptimisedRoute 9Steps 1 · Total yield 12.0916g(Tazobactam (Free))
Tazobactam Sodium-055117030-11-2Tazobactam Sodium-015471-25-0Tazobactam Sodium-01289786-04-9API · Tazobactam Sodium/Ceftolozane
| Code | CAS No. | Intermediate |
|---|---|---|
| Tazobactam Sodium-055 | 117030-11-2Available | (2S,3S,5R)-3-(Azidomethyl)-3-methyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid 4,4-dioxide |
| Tazobactam Sodium-015 | 471-25-0Available | 2-Propynoic acid |
| Tazobactam Sodium-012 | 89786-04-9Available | (2S,3S,5R)-3-Methyl-4,4,7-trioxo-3-(triazol-1-ylmethyl)-4lambda6-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid |
OptimisedRoute 10Steps 2 · Total yield /
Tazobactam Sodium-01289786-04-9API · Tazobactam Sodium/Ceftolozane
| Code | CAS No. | Intermediate |
|---|---|---|
| Tazobactam Sodium-012 | 89786-04-9Available | (2S,3S,5R)-3-Methyl-4,4,7-trioxo-3-(triazol-1-ylmethyl)-4lambda6-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid |
OptimisedRoute 11Steps 9 · Total yield 7.4g(Tazobactam (Free))
Tazobactam Sodium-03079703-02-9Tazobactam Sodium-05674367-78-5Tazobactam Sodium-057618-85-9Tazobactam Sodium-05880078-08-6Tazobactam Sodium-059—Tazobactam Sodium-06076911-22-3Tazobactam Sodium-061—Tazobactam Sodium-002149-30-4Tazobactam Sodium-0622375589-54-9Tazobactam Sodium-063—Tazobactam Sodium-0642375589-55-0Tazobactam Sodium-065—Tazobactam Sodium-0662375589-56-1Tazobactam Sodium-0672376815-36-8Tazobactam Sodium-068117030-09-8Tazobactam Sodium-069—Tazobactam Sodium-01074-86-2Tazobactam Sodium-070117030-07-6Tazobactam Sodium-0712376815-35-7Tazobactam Sodium-01289786-04-9API · Tazobactam Sodium/Ceftolozane
| Code | CAS No. | Intermediate |
|---|---|---|
| Tazobactam Sodium-030 | 79703-02-9Available | (2S,4R,6S)-6-Bromo-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid 4-oxide |
| Tazobactam Sodium-056 | 74367-78-5Available | 1-(Chloromethyl)-3,5-dinitrobenzene |
| Tazobactam Sodium-057 | 618-85-9Available | 1-Methyl-3,5-dinitrobenzene |
| Tazobactam Sodium-058 | 80078-08-6Available | Benzyl (2S,4R,5R,6S)-6-bromo-3,3-dimethyl-4,7-dioxo-4lambda4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate |
| Tazobactam Sodium-059 | - | (3,5-Dinitrophenyl)methyl (2S,4R,5R,6S)-6-bromo-3,3-dimethyl-4,7-dioxo-4lambda4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate |
| Tazobactam Sodium-060 | 76911-22-3Available | Benzyl (2S,4R,5R)-3,3-dimethyl-4,7-dioxo-4lambda4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate |
| Tazobactam Sodium-061 | - | (3,5-Dinitrophenyl)methyl (2S,4R,5R)-3,3-dimethyl-4,7-dioxo-4lambda4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate |
| Tazobactam Sodium-002 | 149-30-4Available | 1,3-Benzothiazole-2-thiol |
| Tazobactam Sodium-062 | 2375589-54-9Available | Benzyl (2R)-2-[(2R)-2-[(1,3-benzothiazol-2-yl)disulfanyl]-4-oxoazetidin-1-yl]-3-methylbut-3-enoate |
| Tazobactam Sodium-063 | - | (3,5-Dinitrophenyl)methyl (2R)-2-[(2R)-2-[(1,3-benzothiazol-2-yl)disulfanyl]-4-oxoazetidin-1-yl]-3-methylbut-3-enoate |
| Tazobactam Sodium-064 | 2375589-55-0Available | Benzyl (2S,3R,5R)-3-(chloromethyl)-3-methyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate |
| Tazobactam Sodium-065 | - | (3,5-Dinitrophenyl)methyl (2S,3R,5R)-3-(chloromethyl)-3-methyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate |
| Tazobactam Sodium-066 | 2375589-56-1Available | Benzyl (2S,3S,5R)-3-(azidomethyl)-3-methyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate |
| Tazobactam Sodium-067 | 2376815-36-8Available | (3,5-Dinitrophenyl)methyl (2S,3S,5R)-3-(azidomethyl)-3-methyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate |
| Tazobactam Sodium-068 | 117030-09-8Available | Benzyl (2S,3S,5R)-3-(azidomethyl)-3-methyl-4,4,7-trioxo-4lambda6-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate |
| Tazobactam Sodium-069 | - | (3,5-Dinitrophenyl)methyl (2S,3S,5R)-3-(azidomethyl)-3-methyl-4,4,7-trioxo-4lambda6-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate |
| Tazobactam Sodium-010 | 74-86-2Available | Acetylene |
| Tazobactam Sodium-070 | 117030-07-6Available | Benzyl (2S,3S,5R)-3-methyl-4,4,7-trioxo-3-[(1H-1,2,3-triazol-1-yl)methyl]-4lambda6-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate |
| Tazobactam Sodium-071 | 2376815-35-7Available | (3,5-Dinitrophenyl)methyl (2S,3S,5R)-3-methyl-4,4,7-trioxo-3-[(1H-1,2,3-triazol-1-yl)methyl]-4lambda6-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate |
| Tazobactam Sodium-012 | 89786-04-9Available | (2S,3S,5R)-3-Methyl-4,4,7-trioxo-3-(triazol-1-ylmethyl)-4lambda6-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid |
OptimisedRoute 12Steps 3 · Total yield 43.6g(Tazobactam Sodium-027)
Tazobactam Sodium-013107-22-2Tazobactam Sodium-0725470-11-1Tazobactam Sodium-07317016-13-6Tazobactam Sodium-017584-14-5Tazobactam Sodium-027288-36-8API · Tazobactam Sodium/Ceftolozane
| Code | CAS No. | Intermediate |
|---|---|---|
| Tazobactam Sodium-013 | 107-22-2Available | Ethanedial |
| Tazobactam Sodium-072 | 5470-11-1Available | Hydroxylamine hydrochloric acid salt |
| Tazobactam Sodium-073 | 17016-13-6Available | N,N'-(1E,2E)-Ethane-1,2-diylidenedihydroxylamine |
| Tazobactam Sodium-017 | 584-14-5Available | 1H-1,2,3-Triazol-1-amine |
| Tazobactam Sodium-027 | 288-36-8Available | 1,2,3-Triazole |
OptimisedRoute 13Steps 5 · Total yield 25.72g(Tazobactam (Free))
Tazobactam Sodium-03379702-81-1Tazobactam Sodium-074—Tazobactam Sodium-075—Tazobactam Sodium-076—Tazobactam Sodium-027288-36-8Tazobactam Sodium-077132182-82-2Tazobactam Sodium-01289786-04-9API · Tazobactam Sodium/Ceftolozane
| Code | CAS No. | Intermediate |
|---|---|---|
| Tazobactam Sodium-033 | 79702-81-1Available | (2S,5R)-3,3-Dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid 4-oxide |
| Tazobactam Sodium-074 | - | (2S,5R)-3-[(Acetyloxy)methyl]-3-methyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid |
| Tazobactam Sodium-075 | - | (2S,5R)-3-(Hydroxymethyl)-3-methyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid |
| Tazobactam Sodium-076 | - | (2S,5R)-3-[[(Methanesulfonyl)oxy]methyl]-3-methyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid |
| Tazobactam Sodium-027 | 288-36-8Available | 1,2,3-Triazole |
| Tazobactam Sodium-077 | 132182-82-2Available | (2S,3S,5R)-3-Methyl-7-oxo-3-[(1H-1,2,3-triazol-1-yl)methyl]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid |
| Tazobactam Sodium-012 | 89786-04-9Available | (2S,3S,5R)-3-Methyl-4,4,7-trioxo-3-(triazol-1-ylmethyl)-4lambda6-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid |
ProcessRoute 2Steps 7 · Total yield 1046.36g(Tazobactam Sodium-009)
Tazobactam Sodium-00485573-73-5Tazobactam Sodium-00989789-07-1Tazobactam Sodium-013107-22-2Tazobactam Sodium-014302-01-2Tazobactam Sodium-0167677-13-6Tazobactam Sodium-017584-14-5Tazobactam Sodium-018—Tazobactam Sodium-019—Tazobactam Sodium-015471-25-0Tazobactam Sodium-020125949-72-6API · Tazobactam Sodium/Ceftolozane
| Code | CAS No. | Intermediate |
|---|---|---|
| Tazobactam Sodium-004 | 85573-73-5Available | (2S-(2alpha,3beta,5alpha))-3-(Chloromethyl)-3-methyl-7-oxo-4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid diphenylmethyl ester |
| Tazobactam Sodium-009 | 89789-07-1Available | Benzhydryl (2S,3S,5R)-3-((1H-1,2,3-triazol-1-yl)methyl)-3-methyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate 4,4-dioxide |
| Tazobactam Sodium-013 | 107-22-2Available | Ethanedial |
| Tazobactam Sodium-014 | 302-01-2Available | Diamine |
| Tazobactam Sodium-016 | 7677-13-6Available | 1,1'-(Ethane-1,2-diylidene)dihydrazine |
| Tazobactam Sodium-017 | 584-14-5Available | 1H-1,2,3-Triazol-1-amine |
| Tazobactam Sodium-018 | - | 3-Amino-1-([(2S,3S,5R)-2-[(diphenylmethoxy)carbonyl]-3-methyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptan-3-yl]methyl)-1H-1,2,3-triazol-3-ium chloride |
| Tazobactam Sodium-019 | - | 3-Amino-1-([(2S,3S,5R)-2-[(diphenylmethoxy)carbonyl]-3-methyl-4,4,7-trioxo-4lambda6-thia-1-azabicyclo[3.2.0]heptan-3-yl]methyl)-1H-1,2,3-triazol-3-ium chloride |
| Tazobactam Sodium-015 | 471-25-0Available | 2-Propynoic acid |
| Tazobactam Sodium-020 | 125949-72-6Available | (2S,3S,5R)-2-Methyl-2-(1H-1,2,3-triazol-1-ylmethyl)penam-3-carboxylic acid diphenylmethyl ester |
Frequently asked questions
What are the approved indications of Tazobactam Sodium/Ceftolozane?
Approved indications include: Intra-abdominal infection, Ventilator-associated pneumonia, Urinary tract infection, Community-acquired bacterial pneumonia, Pyelonephritis, Hospital-acquired pneumonia, Bacterial pneumonia, Cystitis.
When does the Tazobactam Sodium/Ceftolozane patent expire?
No public expiry year is available for Tazobactam Sodium/Ceftolozane yet; this page updates once verified.
How many synthesis routes are recorded for Tazobactam Sodium/Ceftolozane?
13 synthesis routes are recorded; the shortest is 1 steps with / total yield. Intermediates in each route carry codes and CAS numbers.
Where can I buy Tazobactam Sodium/Ceftolozane intermediates?
58 intermediate CAS of Tazobactam Sodium/Ceftolozane are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.
How do I get a quote for Tazobactam Sodium/Ceftolozane intermediates?
Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.
Source: cross-verified data (structured fields only) · 2026-09-29