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Celecoxib

Tier B — Position early

Celecoxib

Pfizer Inc.
Originator
1998
First approval
-
Expiry (public)
$3.33B ▲
Peak sales
Small molecule
Type

Targets:COX-2

Brand:Vyscoxa, Celebrex, Nu-Celecoxib, Celebra, Onsenal, Celecox, Solexa

Indications (approved):Pain, Inflammatory disease, 关节周围炎, 肌腱炎, 颈肩腕综合征, Low back pain, Osteoarthritis, Rheumatoid arthritis

Regional status

US
Approved
1998-12-31
EU
Withdrawn
China
Approved
2000-08-04
Japan
Approved
2007-01-26

Synthetic routes & intermediates5 routes

Originator routes × 1Optimised (non-patent) × 3Process routes × 1

Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.

OriginatorRoute 1Steps 2 · Total yield /
CELE-001122-00-9CELE-002383-63-1CELE-003720-94-5CELE-00417852-52-7API · Celecoxib
CodeCAS No.Intermediate
CELE-001122-00-91-(p-tolyl)ethan-1-one
CELE-002383-63-1ethyl 2,2,2-trifluoroacetate
CELE-003720-94-54,4,4-trifluoro-1-(p-tolyl)butane-1,3-dione
CELE-00417852-52-74-hydrazinylbenzenesulfonamide hydrochloride
OptimisedRoute 2Steps 4 · Total yield 8.7 g
CELE-001122-00-9CELE-00417852-52-7CELE-005915280-81-8CELE-006915280-82-9CELE-00755949-65-0CELE-008110-91-8API · Celecoxib
CodeCAS No.Intermediate
CELE-001122-00-91-(p-tolyl)ethan-1-one
CELE-00417852-52-74-hydrazinylbenzenesulfonamide hydrochloride
CELE-005915280-81-84-(2-(2,2,2-trifluoroacetyl)hydrazinyl)benzenesulfonamide
CELE-006915280-82-9(Z)-benzenesulfonic (Z)-2,2,2-trifluoro-N-(4-sulfamoylphenyl)acetohydrazonic anhydride
CELE-00755949-65-04-(1-(p-tolyl)vinyl)morpholine
CELE-008110-91-8Availablemorpholine
OptimisedRoute 4Steps 1 · Total yield /
CELE-0091401069-79-1API · Celecoxib
CodeCAS No.Intermediate
CELE-0091401069-79-14-(2-((2E,3E)-1,1,1-trifluoro-4-(p-tolyl)but-3-en-2-ylidene)hydrazinyl)benzenesulfonamide
OptimisedRoute 5Steps 2 · Total yield /
CELE-010766-97-2CELE-011948293-46-7API · Celecoxib
CodeCAS No.Intermediate
CELE-010766-97-21-ethynyl-4-methylbenzene
CELE-011948293-46-75-(p-tolyl)-3-(trifluoromethyl)-1H-pyrazole
ProcessRoute 3Steps 1 · Total yield 23.7 Kg
CELE-003720-94-5CELE-00417852-52-7API · Celecoxib
CodeCAS No.Intermediate
CELE-003720-94-54,4,4-trifluoro-1-(p-tolyl)butane-1,3-dione
CELE-00417852-52-74-hydrazinylbenzenesulfonamide hydrochloride

Frequently asked questions

What are the approved indications of Celecoxib?

Approved indications include: Pain, Inflammatory disease, 关节周围炎, 肌腱炎, 颈肩腕综合征, Low back pain, Osteoarthritis, Rheumatoid arthritis.

When does the Celecoxib patent expire?

No public expiry year is available for Celecoxib yet; this page updates once verified.

How many synthesis routes are recorded for Celecoxib?

5 synthesis routes are recorded; the shortest is 1 steps with 23.7 Kg total yield. Intermediates in each route carry codes and CAS numbers.

Where can I buy Celecoxib intermediates?

1 intermediate CAS of Celecoxib are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.

How do I get a quote for Celecoxib intermediates?

Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.

Source: cross-verified data (structured fields only) · 2026-09-29