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Maxacalcitol
Tier C — Watch / tradeMaxacalcitol
Chugai Pharmaceutical Co., Ltd.
Originator
2000
First approval
-
Expiry (public)
No sales data
Peak sales
Small molecule
Type
Targets：VDR
Brand：Oxarol, Prezios
Indications (approved)：Secondary hyperparathyroidism, Hyperparathyroidism
Regional status
US
-
EU
-
China
-
Japan
Approved
2000-07-03
Synthetic routes & intermediates5 routes
Originator routes × 1Optimised (non-patent) × 4Process routes × 0
Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.
OriginatorRoute 1Steps 10 · Total yield /
MAXA-00120998-18-9MAXA-002111594-61-7MAXA-003—MAXA-004103909-62-2MAXA-005111594-62-8MAXA-006103909-74-6MAXA-0075162-44-7MAXA-008103909-76-8MAXA-009103909-77-9MAXA-010103909-78-0MAXA-011152517-44-7API · Maxacalcitol
| Code | CAS No. | Intermediate |
|---|---|---|
| MAXA-001 | 20998-18-9Available | (1S,3R,10R,13S,14S)-1,3-dihydroxy-10,13-dimethyl-1,2,3,4,7,8,9,10,11,12,13,14,15,16-tetradecahydro-17H-cyclopenta[a]phenanthren-17-one |
| MAXA-002 | 111594-61-7Available | (1S,3R,10R,13S,14S)-1,3-bis((tert-butyldimethylsilyl)oxy)-10,13-dimethyl-1,2,3,4,7,8,9,10,11,12,13,14,15,16-tetradecahydro-17H-cyclopenta[a]phenanthren-17-one |
| MAXA-003 | - | (1S,3R,10R,13S,14S)-7-bromo-1,3-bis((tert-butyldimethylsilyl)oxy)-10,13-dimethyl-1,2,3,4,7,8,9,10,11,12,13,14,15,16-tetradecahydro-17H-cyclopenta[a]phenanthren-17-one |
| MAXA-004 | 103909-62-2Available | (1S,3R,10R,13S,14S)-1,3-bis((tert-butyldimethylsilyl)oxy)-10,13-dimethyl-1,2,3,4,9,10,11,12,13,14,15,16-dodecahydro-17H-cyclopenta[a]phenanthren-17-one |
| MAXA-005 | 111594-62-8Available | (((1S,3R,10R,13S,14S,Z)-17-ethylidene-10,13-dimethyl-2,3,4,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene-1,3-diyl)bis(oxy))bis(tert-butyldimethylsilane) |
| MAXA-006 | 103909-74-6Available | (1S)-1-((1S,3R,10R,13S,14R,17S)-1,3-bis((tert-butyldimethylsilyl)oxy)-10,13-dimethyl-2,3,4,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl)ethan-1-ol |
| MAXA-007 | 5162-44-7Available | 4-bromobut-1-ene |
| MAXA-008 | 103909-76-8Available | (((1S,3R,10R,13S,14R,17S)-17-((S)-1-(but-3-en-1-yloxy)ethyl)-10,13-dimethyl-2,3,4,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene-1,3-diyl)bis(oxy))bis(tert-butyldimethylsilane) |
| MAXA-009 | 103909-77-9Available | 4-((1S)-1-((1S,3R,10R,13S,14R,17S)-1,3-bis((tert-butyldimethylsilyl)oxy)-10,13-dimethyl-2,3,4,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl)ethoxy)butan-2-one |
| MAXA-010 | 103909-78-0Available | 4-((1S)-1-((1S,3R,10R,13S,14R,17S)-1,3-bis((tert-butyldimethylsilyl)oxy)-10,13-dimethyl-2,3,4,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl)ethoxy)-2-methylbutan-2-ol |
| MAXA-011 | 152517-44-7Available | 4-((S)-1-((1S,3aS,7aS,E)-4-((Z)-2-((3S,5R)-3,5-bis((tert-butyldimethylsilyl)oxy)-2-methylenecyclohexylidene)ethylidene)-7a-methyloctahydro-1H-inden-1-yl)ethoxy)-2-methylbutan-2-ol |
OptimisedRoute 2Steps 4 · Total yield 136.00 mg
MAXA-006103909-74-6MAXA-010103909-78-0MAXA-012140-88-5MAXA-013137589-77-6MAXA-014142785-61-3API · Maxacalcitol
| Code | CAS No. | Intermediate |
|---|---|---|
| MAXA-006 | 103909-74-6Available | (1S)-1-((1S,3R,10R,13S,14R,17S)-1,3-bis((tert-butyldimethylsilyl)oxy)-10,13-dimethyl-2,3,4,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl)ethan-1-ol |
| MAXA-010 | 103909-78-0Available | 4-((1S)-1-((1S,3R,10R,13S,14R,17S)-1,3-bis((tert-butyldimethylsilyl)oxy)-10,13-dimethyl-2,3,4,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl)ethoxy)-2-methylbutan-2-ol |
| MAXA-012 | 140-88-5Available | ethyl acrylate |
| MAXA-013 | 137589-77-6Available | ethyl 3-((1S)-1-((1S,3R,10R,13S,14R,17S)-1,3-bis((tert-butyldimethylsilyl)oxy)-10,13-dimethyl-2,3,4,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl)ethoxy)propanoate |
| MAXA-014 | 142785-61-3Available | (1S,3R,10R,13S,14R,17S)-17-((S)-1-(3-hydroxy-3-methylbutoxy)ethyl)-10,13-dimethyl-2,3,4,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene-1,3-diol |
OptimisedRoute 3Steps 24 · Total yield 24.00 mg
MAXA-011152517-44-7MAXA-0156485-40-1MAXA-016—MAXA-01735692-59-2MAXA-018191849-75-9MAXA-019191849-78-2MAXA-020121289-20-1MAXA-021191849-76-0MAXA-022191849-77-1MAXA-023145100-51-2MAXA-024191849-74-8MAXA-025—MAXA-026129482-80-0MAXA-02781506-24-3MAXA-02881522-68-1MAXA-029413571-28-5MAXA-030413571-27-4MAXA-03164190-52-9MAXA-03266774-80-9MAXA-033100928-04-9MAXA-034215257-72-0MAXA-035140659-43-4MAXA-036147725-62-0MAXA-037623-47-2MAXA-038192573-34-5MAXA-039192573-35-6MAXA-040413571-29-6API · Maxacalcitol
| Code | CAS No. | Intermediate |
|---|---|---|
| MAXA-011 | 152517-44-7Available | 4-((S)-1-((1S,3aS,7aS,E)-4-((Z)-2-((3S,5R)-3,5-bis((tert-butyldimethylsilyl)oxy)-2-methylenecyclohexylidene)ethylidene)-7a-methyloctahydro-1H-inden-1-yl)ethoxy)-2-methylbutan-2-ol |
| MAXA-015 | 6485-40-1Available | (R)-2-methyl-5-(prop-1-en-2-yl)cyclohex-2-en-1-one |
| MAXA-016 | - | (1R,4R,6R)-1-methyl-4-(prop-1-en-2-yl)-7-oxabicyclo[4.1.0]heptan-2-one |
| MAXA-017 | 35692-59-2Available | (1S,2S,4S,6R)-1-methyl-4-(prop-1-en-2-yl)-7-oxabicyclo[4.1.0]heptan-2-ol |
| MAXA-018 | 191849-75-9Available | (1R,3S,5S,6S)-5-hydroxy-6-methyl-7-oxabicyclo[4.1.0]heptan-3-yl acetate |
| MAXA-019 | 191849-78-2Available | (1S,2S,4S,6R)-1-methyl-7-oxabicyclo[4.1.0]heptane-2,4-diol |
| MAXA-020 | 121289-20-1Available | (((1R,2S,4R,6R)-1-methyl-7-oxabicyclo[4.1.0]heptane-2,4-diyl)bis(oxy))bis(tert-butyldimethylsilane) |
| MAXA-021 | 191849-76-0Available | (3S,5S)-3,5-bis((tert-butyldimethylsilyl)oxy)-6-oxoheptanal |
| MAXA-022 | 191849-77-1Available | (3S,5R)-8,8-dibromo-3,5-bis((tert-butyldimethylsilyl)oxy)oct-7-en-2-one |
| MAXA-023 | 145100-51-2Available | N-(5-chloropyridin-2-yl)-1,1,1-trifluoro-N-((trifluoromethyl)sulfonyl)methanesulfonamide |
| MAXA-024 | 191849-74-8Available | (3S,5R)-3,5-bis((tert-butyldimethylsilyl)oxy)oct-1-en-7-yn-2-yl trifluoromethanesulfonate |
| MAXA-025 | - | methyl 2-((3S,5R)-3,5-bis((tert-butyldimethylsilyl)oxy)-2-methylenecyclohexylidene)acetate |
| MAXA-026 | 129482-80-0Available | methyl (Z)-2-((3S,5R)-3,5-bis((tert-butyldimethylsilyl)oxy)-2-methylenecyclohexylidene)acetate |
| MAXA-027 | 81506-24-3Available | (Z)-2-((3S,5R)-3,5-bis((tert-butyldimethylsilyl)oxy)-2-methylenecyclohexylidene)ethan-1-ol |
| MAXA-028 | 81522-68-1Available | ((Z)-2-((3S,5R)-3,5-bis((tert-butyldimethylsilyl)oxy)-2-methylenecyclohexylidene)ethyl)diphenylphosphine oxide |
| MAXA-029 | 413571-28-5Available | ethyl 3-((S)-1-((1S,3aR,7aR)-7a-methyl-4-oxooctahydro-1H-inden-1-yl)ethoxy)propanoate |
| MAXA-030 | 413571-27-4Available | ethyl 3-((S)-1-((1S,3aS,7aS,E)-4-((Z)-2-((3S,5R)-3,5-bis((tert-butyldimethylsilyl)oxy)-2-methylenecyclohexylidene)ethylidene)-7a-methyloctahydro-1H-inden-1-yl)ethoxy)propanoate |
| MAXA-031 | 64190-52-9Available | (1R,3aR,4S,7aR)-1-((S)-1-hydroxypropan-2-yl)-7a-methyloctahydro-1H-inden-4-ol |
| MAXA-032 | 66774-80-9Available | (S)-2-((1R,3aR,4S,7aR)-4-hydroxy-7a-methyloctahydro-1H-inden-1-yl)propyl 4-methylbenzenesulfonate |
| MAXA-033 | 100928-04-9Available | (S)-2-((1R,3aR,4S,7aR)-4-((tert-butyldimethylsilyl)oxy)-7a-methyloctahydro-1H-inden-1-yl)propyl 4-methylbenzenesulfonate |
| MAXA-034 | 215257-72-0Available | tert-butyldimethyl(((1R,3aR,4S,7aR)-7a-methyl-1-(prop-1-en-2-yl)octahydro-1H-inden-4-yl)oxy)silane |
| MAXA-035 | 140659-43-4Available | 1-((1S,3aR,4S,7aS)-4-((tert-butyldimethylsilyl)oxy)-7a-methyloctahydro-1H-inden-1-yl)ethan-1-one |
| MAXA-036 | 147725-62-0Available | (S)-1-((1S,3aR,4S,7aR)-4-((tert-butyldimethylsilyl)oxy)-7a-methyloctahydro-1H-inden-1-yl)ethan-1-ol |
| MAXA-037 | 623-47-2Available | ethyl propiolate |
| MAXA-038 | 192573-34-5Available | ethyl (E)-3-((S)-1-((1S,3aR,4S,7aR)-4-((tert-butyldimethylsilyl)oxy)-7a-methyloctahydro-1H-inden-1-yl)ethoxy)acrylate |
| MAXA-039 | 192573-35-6Available | ethyl 3-((S)-1-((1S,3aR,4S,7aR)-4-((tert-butyldimethylsilyl)oxy)-7a-methyloctahydro-1H-inden-1-yl)ethoxy)propanoate |
| MAXA-040 | 413571-29-6Available | ethyl 3-((S)-1-((1S,3aR,4S,7aS)-4-hydroxy-7a-methyloctahydro-1H-inden-1-yl)ethoxy)propanoate |
OptimisedRoute 4Steps 8 · Total yield 646.00 mg
MAXA-02881522-68-1MAXA-035140659-43-4MAXA-036147725-62-0MAXA-0411120-79-2MAXA-0421620977-72-1MAXA-043192573-36-7MAXA-044192573-37-8MAXA-045884488-07-7MAXA-0461309888-30-9MAXA-047—API · Maxacalcitol
| Code | CAS No. | Intermediate |
|---|---|---|
| MAXA-028 | 81522-68-1Available | ((Z)-2-((3S,5R)-3,5-bis((tert-butyldimethylsilyl)oxy)-2-methylenecyclohexylidene)ethyl)diphenylphosphine oxide |
| MAXA-035 | 140659-43-4Available | 1-((1S,3aR,4S,7aS)-4-((tert-butyldimethylsilyl)oxy)-7a-methyloctahydro-1H-inden-1-yl)ethan-1-one |
| MAXA-036 | 147725-62-0Available | (S)-1-((1S,3aR,4S,7aR)-4-((tert-butyldimethylsilyl)oxy)-7a-methyloctahydro-1H-inden-1-yl)ethan-1-ol |
| MAXA-041 | 1120-79-2Available | 3-(bromomethyl)-2,2-dimethyloxirane |
| MAXA-042 | 1620977-72-1Available | tert-butyl(((1S,3aR,4S,7aR)-1-((1S)-1-((3,3-dimethyloxiran-2-yl)methoxy)ethyl)-7a-methyloctahydro-1H-inden-4-yl)oxy)dimethylsilane |
| MAXA-043 | 192573-36-7Available | 4-((S)-1-((1S,3aR,4S,7aR)-4-((tert-butyldimethylsilyl)oxy)-7a-methyloctahydro-1H-inden-1-yl)ethoxy)-2-methylbutan-2-ol |
| MAXA-044 | 192573-37-8Available | (1S,3aR,4S,7aS)-1-((S)-1-(3-hydroxy-3-methylbutoxy)ethyl)-7a-methyloctahydro-1H-inden-4-ol |
| MAXA-045 | 884488-07-7Available | (1S,3aR,7aR)-1-((S)-1-(3-hydroxy-3-methylbutoxy)ethyl)-7a-methyloctahydro-4H-inden-4-one |
| MAXA-046 | 1309888-30-9Available | - |
| MAXA-047 | - | - |
OptimisedRoute 5Steps 11 · Total yield 19.30 g
MAXA-0411120-79-2MAXA-04850-14-6MAXA-049104846-62-0MAXA-050170081-43-3MAXA-051866453-60-3MAXA-0521541206-78-3MAXA-0531541206-80-7MAXA-0541329004-06-9MAXA-0551610782-99-4MAXA-0561329004-16-1MAXA-0571329004-19-4MAXA-058103909-75-7MAXA-059784-04-3API · Maxacalcitol
| Code | CAS No. | Intermediate |
|---|---|---|
| MAXA-041 | 1120-79-2Available | 3-(bromomethyl)-2,2-dimethyloxirane |
| MAXA-048 | 50-14-6Available | (S,Z)-3-((E)-2-((1R,3aS,7aR)-1-((2R,5R,E)-5,6-dimethylhept-3-en-2-yl)-7a-methylhexahydro-1H-inden-4(2H)-ylidene)ethylidene)-4-methylenecyclohexanol |
| MAXA-049 | 104846-62-0Available | tert-butyl(((S,Z)-3-(2-((1R,3aS,7aR,E)-1-((2R,5R,E)-5,6-dimethylhept-3-en-2-yl)-7a-methyloctahydro-4H-inden-4-ylidene)ethylidene)-4-methylenecyclohexyl)oxy)dimethylsilane |
| MAXA-050 | 170081-43-3Available | 2-((1R,3aS,7aR,E)-4-(((6S)-6-((tert-butyldimethylsilyl)oxy)-2,2-dioxido-1,3,4,5,6,7-hexahydrobenzo[c]thiophen-1-yl)methylene)-7a-methyloctahydro-1H-inden-1-yl)propanal |
| MAXA-051 | 866453-60-3Available | (2S)-2-((1R,3aS,7aR,E)-4-(((6S)-6-((tert-butyldimethylsilyl)oxy)-2,2-dioxido-1,3,4,5,6,7-hexahydrobenzo[c]thiophen-1-yl)methylene)-7a-methyloctahydro-1H-inden-1-yl)propanal |
| MAXA-052 | 1541206-78-3Available | 1-((1S,3aS,7aS,E)-4-(((6S)-6-((tert-butyldimethylsilyl)oxy)-2,2-dioxido-1,3,4,5,6,7-hexahydrobenzo[c]thiophen-1-yl)methylene)-7a-methyloctahydro-1H-inden-1-yl)ethan-1-one |
| MAXA-053 | 1541206-80-7Available | (6S)-6-((tert-butyldimethylsilyl)oxy)-1-(((1S,3aS,7aS,E)-1-((S)-1-hydroxyethyl)-7a-methyloctahydro-4H-inden-4-ylidene)methyl)-1,3,4,5,6,7-hexahydrobenzo[c]thiophene 2,2-dioxide |
| MAXA-054 | 1329004-06-9Available | (S)-1-((1S,3aS,7aS,E)-4-((E)-2-((S)-5-((tert-butyldimethylsilyl)oxy)-2-methylenecyclohexylidene)ethylidene)-7a-methyloctahydro-1H-inden-1-yl)ethan-1-ol |
| MAXA-055 | 1610782-99-4Available | tert-butyl(((1S,E)-3-(2-((1S,3aS,7aS,E)-1-((1S)-1-((3,3-dimethyloxiran-2-yl)methoxy)ethyl)-7a-methyloctahydro-4H-inden-4-ylidene)ethylidene)-4-methylenecyclohexyl)oxy)dimethylsilane |
| MAXA-056 | 1329004-16-1Available | 4-((S)-1-((1S,3aS,7aS,E)-4-((E)-2-((S)-5-((tert-butyldimethylsilyl)oxy)-2-methylenecyclohexylidene)ethylidene)-7a-methyloctahydro-1H-inden-1-yl)ethoxy)-2-methylbutan-2-ol |
| MAXA-057 | 1329004-19-4Available | (1S,5R,E)-5-((tert-butyldimethylsilyl)oxy)-3-(2-((1S,3aS,7aS,E)-1-((S)-1-(3-hydroxy-3-methylbutoxy)ethyl)-7a-methyloctahydro-4H-inden-4-ylidene)ethylidene)-2-methylenecyclohexan-1-ol |
| MAXA-058 | 103909-75-7Available | (1R,3S,E)-5-(2-((1S,3aS,7aS,E)-1-((S)-1-(3-hydroxy-3-methylbutoxy)ethyl)-7a-methyloctahydro-4H-inden-4-ylidene)ethylidene)-4-methylenecyclohexane-1,3-diol |
| MAXA-059 | 784-04-3Available | 1-(anthracen-9-yl)ethan-1-one |
Frequently asked questions
What are the approved indications of Maxacalcitol?
Approved indications include: Secondary hyperparathyroidism, Hyperparathyroidism.
When does the Maxacalcitol patent expire?
No public expiry year is available for Maxacalcitol yet; this page updates once verified.
How many synthesis routes are recorded for Maxacalcitol?
5 synthesis routes are recorded; the shortest is 4 steps with 136.00 mg total yield. Intermediates in each route carry codes and CAS numbers.
Where can I buy Maxacalcitol intermediates?
55 intermediate CAS of Maxacalcitol are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.
How do I get a quote for Maxacalcitol intermediates?
Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.
Source: cross-verified data (structured fields only) · 2026-09-29