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Imipenem
Tier C — Watch / tradeImipenem
Shenzhen Haibin Pharmaceutical Co., Ltd.
Originator
1985
First approval
-
Expiry (public)
No sales data
Peak sales
Small molecule
Type
Targets：PBPs
Indications (approved)：Bacterial infection, Gonorrhoea, Bacillus anthracis infection
Regional status
US
-
EU
-
China
Approved
2005-12-01
Japan
-
Factories producing this API1
Factories registered as producing this API in our sourcing network (RFQ records + product master), sorted by RFQ activity; the snapshot carries no cost or customer data.
1 producing factories on file — sign in to view the named list (factory details are not shown to guests).
Sign in to view factories →Synthetic routes & intermediates7 routes
Originator routes × 0Optimised (non-patent) × 7Process routes × 0
Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.
OptimisedRoute 1Steps 1 · Total yield /
Imipenem-00159995-64-1Imipenem-002—API · Imipenem
| Code | CAS No. | Intermediate |
|---|---|---|
| Imipenem-001 | 59995-64-1 | (5R,6S)-3-[(2-aminoethyl)sulfanyl]-6-[(1R)-1-hydroxyethyl]-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid |
| Imipenem-002 | - | methyl methanecarboximidate |
OptimisedRoute 2Steps 7 · Total yield /
Imipenem-00159995-64-1Imipenem-002—API · Imipenem
| Code | CAS No. | Intermediate |
|---|---|---|
| Imipenem-001 | 59995-64-1 | (5R,6S)-3-[(2-aminoethyl)sulfanyl]-6-[(1R)-1-hydroxyethyl]-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid |
| Imipenem-002 | - | methyl methanecarboximidate |
OptimisedRoute 3Steps 9 · Total yield /
Imipenem-015104-94-9Imipenem-016371-40-4Imipenem-017106-40-1Imipenem-018156-43-4Imipenem-01970-11-1Imipenem-02078-95-5Imipenem-02118276-97-6Imipenem-0225469-26-1Imipenem-0235883-82-9Imipenem-024214285-87-7Imipenem-0251426146-10-2Imipenem-0261426146-05-5Imipenem-0271426146-15-7Imipenem-028—Imipenem-029—Imipenem-030—Imipenem-031—Imipenem-032—Imipenem-03386561-72-0Imipenem-03472-19-5Imipenem-03594944-06-6Imipenem-036104421-31-0Imipenem-0371426146-11-3Imipenem-0381426146-06-6Imipenem-0391426146-16-8Imipenem-040—Imipenem-041—Imipenem-042—Imipenem-043—Imipenem-044—Imipenem-0452211955-41-6Imipenem-046141781-29-5Imipenem-047203252-14-6Imipenem-0481426146-14-6Imipenem-0491426146-09-9Imipenem-0501426146-19-1Imipenem-051106399-63-7Imipenem-00376855-69-1API · Imipenem
| Code | CAS No. | Intermediate |
|---|---|---|
| Imipenem-015 | 104-94-9 | 4-Methoxyphenylamine |
| Imipenem-016 | 371-40-4Available | 1-Amino-4-fluorobenzene |
| Imipenem-017 | 106-40-1Available | 4-Bromophenylamine |
| Imipenem-018 | 156-43-4 | 4-Ethoxyphenylamine |
| Imipenem-019 | 70-11-1 | omega-Bromoacetophenone |
| Imipenem-020 | 78-95-5 | Chloroacetyl chloride |
| Imipenem-021 | 18276-97-6 | 2-Iodo-1-(3-methoxyphenyl)ethanone |
| Imipenem-022 | 5469-26-1 | 1-Bromo-3,3-dimethylbutan-2-one<-fgf-> |
| Imipenem-023 | 5883-82-9 | 2-[(4-Methoxyphenyl)amino]-1-phenylethanone |
| Imipenem-024 | 214285-87-7 | 1-[(4-Methoxyphenyl)amino]acetone |
| Imipenem-025 | 1426146-10-2 | 1-[(4-Fluorophenyl)amino]acetone |
| Imipenem-026 | 1426146-05-5 | 2-[(4-Bromophenyl)amino]-1-(3-methoxyphenyl)ethanone |
| Imipenem-027 | 1426146-15-7 | 1-[(4-Ethoxyphenyl)amino]-3,3-dimethylbutan-2-one |
| Imipenem-028 | - | (3S)-4-Benzoyl-3-[(1R)-1-[[tert-butyl(dimethyl)silyl]oxy]ethyl]-1-(4-methoxyphenyl)azetidin-2-one |
| Imipenem-029 | - | (3S)-4-Acetyl-3-[(1R)-1-[[tert-butyl(dimethyl)silyl]oxy]ethyl]-1-(4-methoxyphenyl)azetidin-2-one |
| Imipenem-030 | - | (3S)-4-Acetyl-3-[(1R)-1-[[tert-butyl(dimethyl)silyl]oxy]ethyl]-1-(4-fluorophenyl)azetidin-2-one |
| Imipenem-031 | - | (3S)-1-(4-Bromophenyl)-3-[(1R)-1-[[tert-butyl(dimethyl)silyl]oxy]ethyl]-4-(3-methoxybenzoyl)azetidin-2-one |
| Imipenem-032 | - | (3S)-3-[(1R)-1-[[tert-Butyl(dimethyl)silyl]oxy]ethyl]-4-(2,2-dimethylpropanoyl)-1-(4-ethoxyphenyl)azetidin-2-one |
| Imipenem-033 | 86561-72-0 | (2R,3R)-3-Methyloxirane-2-carboxylic acid |
| Imipenem-034 | 72-19-5 | L-Threonine |
| Imipenem-035 | 94944-06-6 | (2R,3R)-N-(4-Methoxyphenyl)-3-methyl-N-(2-oxo-2-phenylethyl)oxirane-2-carboxamide |
| Imipenem-036 | 104421-31-0 | (2R,3R)-N-(4-Methoxyphenyl)-3-methyl-N-(2-oxopropyl)oxirane-2-carboxamide |
| Imipenem-037 | 1426146-11-3 | (2R,3R)-N-(4-Fluorophenyl)-3-methyl-N-(2-oxopropyl)oxirane-2-carboxamide |
| Imipenem-038 | 1426146-06-6 | (2R,3R)-N-(4-Bromophenyl)-N-[2-(3-methoxyphenyl)-2-oxoethyl]-3-methyloxirane-2-carboxamide |
| Imipenem-039 | 1426146-16-8 | (2R,3R)-N-(3,3-Dimethyl-2-oxobutyl)-N-(4-ethoxyphenyl)-3-methyloxirane-2-carboxamide |
| Imipenem-040 | - | (3S)-4-Benzoyl-3-[(1R)-1-hydroxyethyl]-1-(4-methoxyphenyl)azetidin-2-one |
| Imipenem-041 | - | (3S)-4-Acetyl-3-[(1R)-1-hydroxyethyl]-1-(4-methoxyphenyl)azetidin-2-one |
| Imipenem-042 | - | (3S)-4-Acetyl-1-(4-fluorophenyl)-3-[(1R)-1-hydroxyethyl]azetidin-2-one |
| Imipenem-043 | - | (3S)-1-(4-Bromophenyl)-3-[(1R)-1-hydroxyethyl]-4-(3-methoxybenzoyl)azetidin-2-one |
| Imipenem-044 | - | (3S)-4-(2,2-Dimethylpropanoyl)-1-(4-ethoxyphenyl)-3-[(1R)-1-hydroxyethyl]azetidin-2-one |
| Imipenem-045 | 2211955-41-6 | (1E)-1-[(4-Methoxyphenyl)imino]acetone |
| Imipenem-046 | 141781-29-5 | S-Pyridin-2-yl (3R)-3-[[tert-butyl(dimethyl)silyl]oxy]butanethioate |
| Imipenem-047 | 203252-14-6 | (2R,3R)-3-[(1R)-1-[[tert-Butyl(dimethyl)silyl]oxy]ethyl]-1-(4-methoxyphenyl)-4-oxoazetidin-2-yl acetate |
| Imipenem-048 | 1426146-14-6 | (2R,3R)-3-[(1R)-1-[[tert-Butyl(dimethyl)silyl]oxy]ethyl]-1-(4-fluorophenyl)-4-oxoazetidin-2-yl acetate |
| Imipenem-049 | 1426146-09-9 | (2R,3R)-1-(4-Bromophenyl)-3-[(1R)-1-[[tert-butyl(dimethyl)silyl]oxy]ethyl]-4-oxoazetidin-2-yl acetate |
| Imipenem-050 | 1426146-19-1 | (2R,3R)-3-[(1R)-1-[[tert-Butyl(dimethyl)silyl]oxy]ethyl]-1-(4-ethoxyphenyl)-4-oxoazetidin-2-yl acetate |
| Imipenem-051 | 106399-63-7 | (2S,3S)-3-[(1R)-1-[[tert-Butyl(dimethyl)silyl]oxy]ethyl]-1-(4-methoxyphenyl)-4-oxoazetidine-2-carboxylic acid |
| Imipenem-003 | 76855-69-1 | (2R,3R)-3-[(1R)-1-[[tert-Butyl(dimethyl)silyl]oxy]ethyl]-4-oxoazetidin-2-yl acetate |
OptimisedRoute 4Steps 4 · Total yield /
Imipenem-052854684-54-1Imipenem-053854684-53-0Imipenem-054442847-69-0Imipenem-055—Imipenem-0562249962-68-1Imipenem-0572249962-67-0Imipenem-058854684-55-2Imipenem-00874288-40-7Imipenem-0092524-64-3Imipenem-01075321-08-3Imipenem-01160-23-1,156-57-0Imipenem-01285737-65-1Imipenem-014127608-39-3API · Imipenem
| Code | CAS No. | Intermediate |
|---|---|---|
| Imipenem-052 | 854684-54-1 | (4-Methoxyphenyl)methyl (5R,6S)-6-[(1R)-1-hydroxyethyl]-3,7-dioxo-1-azabicyclo[3.2.0]heptane-2-carboxylate |
| Imipenem-053 | 854684-53-0 | (4-Methoxyphenyl)methyl (5R,6S)-3-[(diphenoxyphosphoryl)oxy]-6-[(1R)-1-hydroxyethyl]-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate |
| Imipenem-054 | 442847-69-0 | 4-Nitrobenzyl (5R,6S)-3-[(2-aminoethyl)sulfanyl]-6-[(1R)-1-hydroxyethyl]-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate hydrochloride |
| Imipenem-055 | - | (4-Methoxyphenyl)methyl (5R,6S)-3-[(2-aminoethyl)sulfanyl]-6-[(1R)-1-hydroxyethyl]-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate--hydrogen chloride (1/1) |
| Imipenem-056 | 2249962-68-1 | (4-Methoxyphenyl)methyl methanimidate |
| Imipenem-057 | 2249962-67-0 | (4-Nitrophenyl)methyl methanimidate |
| Imipenem-058 | 854684-55-2 | (4-Methoxyphenyl)methyl (5R,6S)-6-[(1R)-1-hydroxyethyl]-3-([2-[(iminomethyl)amino]ethyl]sulfanyl)-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate |
| Imipenem-008 | 74288-40-7 | (5R,6S)-6-[1(R)-Hydroxyethyl]-3,7-dioxo-1-azabicyclo[3.2.0]heptane-2-carboxylic acid 4-nitrobenzyl ester |
| Imipenem-009 | 2524-64-3 | Diphenyl chlorophosphate |
| Imipenem-010 | 75321-08-3 | 4-Nitrobenzyl (5R,6S)-3-[(diphenoxyphosphoryl)oxy]-6-[(1R)-1-hydroxyethyl]-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate |
| Imipenem-011 | 60-23-1,156-57-0 | Cysteaminium chloride |
| Imipenem-012 | 85737-65-1 | Benzyl imidoformate |
| Imipenem-014 | 127608-39-3 | (5R,6S)-6-[1(R)-Hydroxyethyl]-3-[2-(iminomethylamino)ethylsulfanyl]-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid 4-nitrobenzyl ester |
OptimisedRoute 5Steps 6 · Total yield /
Imipenem-059126579-20-2Imipenem-0602043074-82-2Imipenem-0612043074-46-8Imipenem-062156-57-0,60-23-1Imipenem-0632043074-48-0Imipenem-00376855-69-1Imipenem-00493788-47-7Imipenem-00593861-39-3Imipenem-01360099-09-4API · Imipenem
| Code | CAS No. | Intermediate |
|---|---|---|
| Imipenem-059 | 126579-20-2 | 4-Nitrobenzyl (5R,6S)-6-[(1R)-1-[[tert-butyl(dimethyl)silyl]oxy]ethyl]-3,7-dioxo-1-azabicyclo[3.2.0]heptane-2-carboxylate |
| Imipenem-060 | 2043074-82-2 | 4-Nitrobenzyl (5R,6S)-6-[(1R)-1-[[tert-butyl(dimethyl)silyl]oxy]ethyl]-3-([2-[(iminomethyl)amino]ethyl]sulfanyl)-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate hydrogen chloride |
| Imipenem-061 | 2043074-46-8 | 4-Nitrobenzyl (5R,6S)-6-[(1R)-1-[[tert-butyl(dimethyl)silyl]oxy]ethyl]-3-[(diphenoxyphosphoryl)oxy]-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate |
| Imipenem-062 | 156-57-0,60-23-1 | 2-Mercaptoethylamine hydrochloride |
| Imipenem-063 | 2043074-48-0 | 4-Nitrobenzyl (5R,6S)-3-[(2-aminoethyl)sulfanyl]-6-[(1R)-1-[[tert-butyl(dimethyl)silyl]oxy]ethyl]-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate hydrogen chloride |
| Imipenem-003 | 76855-69-1 | 2(R)-Acetoxy-3(R)-[O-TBDMS-1(R)-hydroxyethyl]-4-azetidinone |
| Imipenem-004 | 93788-47-7 | (4-Nitrophenyl)methyl 2-diazo-3-[(trimethylsilyl)oxy]but-3-enoate |
| Imipenem-005 | 93861-39-3 | 4-[3(S)-[1(R)-[tert-Butyl(dimethyl)silyloxy]ethyl]-4-oxoazetidin-2(R)-yl]-2-diazo-3-oxobutyric acid 4-nitrobenzyl ester |
| Imipenem-013 | 60099-09-4 | Benzyl imidoformate hydrogen chloride |
OptimisedRoute 6Steps 3 · Total yield /
Imipenem-064124-68-5Imipenem-065503-38-8Imipenem-06626654-39-7Imipenem-067563-76-8Imipenem-068114341-88-7API · Imipenem
| Code | CAS No. | Intermediate |
|---|---|---|
| Imipenem-064 | 124-68-5Available | 2,2-Dimethylaminoethanol |
| Imipenem-065 | 503-38-8 | Chloridocarbonic acid trichloromethyl ester |
| Imipenem-066 | 26654-39-7 | 4,4-Dimethyl-1,3-oxazolidin-2-one |
| Imipenem-067 | 563-76-8 | 2-Bromopropanoyl bromide |
| Imipenem-068 | 114341-88-7 | 3-(2-Bromopropanoyl)-4,4-dimethyl-1,3-oxazolidin-2-one |
OptimisedRoute 7Steps 2 · Total yield /
Imipenem-069—Imipenem-070442847-70-3Imipenem-01360099-09-4API · Imipenem
| Code | CAS No. | Intermediate |
|---|---|---|
| Imipenem-069 | - | (4-Nitrophenyl)methyl (5R,6S)-3-[(2-aminoethyl)sulfanyl]-6-[(1R)-1-hydroxyethyl]-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate 1-methylpyrrolidin-2-one hydrogen chloride |
| Imipenem-070 | 442847-70-3 | (4-Nitrophenyl)methyl (5R,6S)-6-[(1R)-1-hydroxyethyl]-3-([2-[(iminomethyl)amino]ethyl]sulfanyl)-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate hydrogen chloride |
| Imipenem-013 | 60099-09-4 | Benzyl imidoformate hydrogen chloride |
Frequently asked questions
What are the approved indications of Imipenem?
Approved indications include: Bacterial infection, Gonorrhoea, Bacillus anthracis infection.
When does the Imipenem patent expire?
No public expiry year is available for Imipenem yet; this page updates once verified.
How many synthesis routes are recorded for Imipenem?
7 synthesis routes are recorded; the shortest is 1 steps with / total yield. Intermediates in each route carry codes and CAS numbers.
Where can I buy Imipenem intermediates?
3 intermediate CAS of Imipenem are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.
How do I get a quote for Imipenem intermediates?
Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.
Source: cross-verified data (structured fields only) · 2026-09-29