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Fosamprenavir Calcium
Tier C — Watch / tradeFosamprenavir Calcium
Vertex Pharmaceuticals Incorporated
Originator
2003
First approval
-
Expiry (public)
No sales data
Peak sales
Small molecule
Type
Targets：HIV-1 protease
Brand：Telzir, Lexiva
Indications (approved)：HIV infection
Regional status
US
Withdrawn
EU
Withdrawn
China
-
Japan
Approved
2004-12-24
Synthetic routes & intermediates5 routes
Originator routes × 1Optimised (non-patent) × 4Process routes × 0
Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.
OriginatorRoute 1Steps 5 · Total yield 12.40 mg
FOSAC-001160232-08-6FOSAC-002160232-10-0FOSAC-003160232-11-1FOSAC-004138499-08-8FOSAC-005160232-12-2FOSAC-006160232-13-3FOSAC-00798-74-8FOSAC-008160231-69-6API · Fosamprenavir Calcium
| Code | CAS No. | Intermediate |
|---|---|---|
| FOSAC-001 | 160232-08-6 | tert-butyl ((2S,3R)-3-hydroxy-4-(isobutylamino)-1-phenylbutan-2-yl)carbamate |
| FOSAC-002 | 160232-10-0 | benzyl ((2R,3S)-3-((tert-butoxycarbonyl)amino)-2-hydroxy-4-phenylbutyl)(isobutyl)carbamate |
| FOSAC-003 | 160232-11-1 | benzyl ((2R,3S)-3-amino-2-hydroxy-4-phenylbutyl)(isobutyl)carbamate hydrochloride |
| FOSAC-004 | 138499-08-8 | (S)-2,5-dioxopyrrolidin-1-yl (tetrahydrofuran-3-yl) carbonate |
| FOSAC-005 | 160232-12-2 | benzyl ((2R,3S)-2-hydroxy-4-phenyl-3-(((((S)-tetrahydrofuran-3-yl)oxy)carbonyl)amino)butyl)(isobutyl)carbamate |
| FOSAC-006 | 160232-13-3 | (S)-tetrahydrofuran-3-yl ((2S,3R)-3-hydroxy-4-(isobutylamino)-1-phenylbutan-2-yl)carbamate |
| FOSAC-007 | 98-74-8 | 4-nitrobenzenesulfonyl chloride |
| FOSAC-008 | 160231-69-6 | (S)-tetrahydrofuran-3-yl ((2S,3R)-3-hydroxy-4-(N-isobutyl-4-nitrophenylsulfonamido)-1-phenylbutan-2-yl)carbamate |
OptimisedRoute 2Steps 10 · Total yield 7.52 g
FOSAC-001160232-08-6FOSAC-00798-74-8FOSAC-008160231-69-6FOSAC-00963-91-2FOSAC-010111060-64-1FOSAC-011166987-15-1FOSAC-012166987-16-2FOSAC-01398737-29-2FOSAC-014244634-31-9FOSAC-015317345-83-8FOSAC-016229495-87-8FOSAC-017229495-86-7API · Fosamprenavir Calcium
| Code | CAS No. | Intermediate |
|---|---|---|
| FOSAC-001 | 160232-08-6 | tert-butyl ((2S,3R)-3-hydroxy-4-(isobutylamino)-1-phenylbutan-2-yl)carbamate |
| FOSAC-007 | 98-74-8 | 4-nitrobenzenesulfonyl chloride |
| FOSAC-008 | 160231-69-6 | (S)-tetrahydrofuran-3-yl ((2S,3R)-3-hydroxy-4-(N-isobutyl-4-nitrophenylsulfonamido)-1-phenylbutan-2-yl)carbamate |
| FOSAC-009 | 63-91-2 | L-phenylalanine |
| FOSAC-010 | 111060-64-1 | (S)-2-(dibenzylamino)-3-phenylpropanal |
| FOSAC-011 | 166987-15-1 | (2S,3S)-1-chloro-3-(dibenzylamino)-4-phenylbutan-2-ol hydrochloride |
| FOSAC-012 | 166987-16-2 | (2S,3S)-3-amino-1-chloro-4-phenylbutan-2-ol hydrochloride |
| FOSAC-013 | 98737-29-2 | tert-butyl ((S)-1-((S)-oxiran-2-yl)-2-phenylethyl)carbamate |
| FOSAC-014 | 244634-31-9 | N-((2R,3S)-3-amino-2-hydroxy-4-phenylbutyl)-N-isobutyl-4-nitrobenzenesulfonamide hydrochloride |
| FOSAC-015 | 317345-83-8 | (S)-tetrahydrofuran-3-yl 1H-imidazole-1-carboxylate |
| FOSAC-016 | 229495-87-8 | (S)-tetrahydrofuran-3-yl ((2S,3R)-4-((N-isobutyl-4-nitrophenyl)sulfonamido)-1-phenyl-3-(phosphonooxy)butan-2-yl)carbamate |
| FOSAC-017 | 229495-86-7 | (S)-tetrahydrofuran-3-yl ((2S,3R)-4-((4-amino-N-isobutylphenyl)sulfonamido)-1-phenyl-3-(phosphonooxy)butan-2-yl)carbamate |
OptimisedRoute 3Steps 4 · Total yield 25.8 kg
FOSAC-008160231-69-6FOSAC-016229495-87-8FOSAC-018229495-86-7API · Fosamprenavir Calcium
| Code | CAS No. | Intermediate |
|---|---|---|
| FOSAC-008 | 160231-69-6 | (S)-tetrahydrofuran-3-yl ((2S,3R)-3-hydroxy-4-(N-isobutyl-4-nitrophenylsulfonamido)-1-phenylbutan-2-yl)carbamate |
| FOSAC-016 | 229495-87-8 | (S)-tetrahydrofuran-3-yl ((2S,3R)-4-((N-isobutyl-4-nitrophenyl)sulfonamido)-1-phenyl-3-(phosphonooxy)butan-2-yl)carbamate |
| FOSAC-018 | 229495-86-7 | (S)-tetrahydrofuran-3-yl ((2S,3R)-4-((4-amino-N-isobutylphenyl)sulfonamido)-1-phenyl-3-(phosphonooxy)butan-2-yl)carbamate |
OptimisedRoute 4Steps 6 · Total yield 5.00 g
FOSAC-001160232-08-6FOSAC-01398737-29-2FOSAC-015317345-83-8FOSAC-017229495-86-7FOSAC-0194435-59-0FOSAC-0201333313-44-2FOSAC-021190444-93-0FOSAC-0221333313-45-3API · Fosamprenavir Calcium
| Code | CAS No. | Intermediate |
|---|---|---|
| FOSAC-001 | 160232-08-6 | tert-butyl ((2S,3R)-3-hydroxy-4-(isobutylamino)-1-phenylbutan-2-yl)carbamate |
| FOSAC-013 | 98737-29-2 | tert-butyl ((S)-1-((S)-oxiran-2-yl)-2-phenylethyl)carbamate |
| FOSAC-015 | 317345-83-8 | (S)-tetrahydrofuran-3-yl 1H-imidazole-1-carboxylate |
| FOSAC-017 | 229495-86-7 | (S)-tetrahydrofuran-3-yl ((2S,3R)-4-((4-amino-N-isobutylphenyl)sulfonamido)-1-phenyl-3-(phosphonooxy)butan-2-yl)carbamate |
| FOSAC-019 | 4435-59-0 | 4-(1,3-dioxoisoindolin-2-yl)benzenesulfonyl chloride |
| FOSAC-020 | 1333313-44-2 | N-((2R,3S)-3-amino-2-hydroxy-4-phenylbutyl)-4-(1,3-dioxoisoindolin-2-yl)-N-isobutylbenzenesulfonamide hydrochloride |
| FOSAC-021 | 190444-93-0 | (S)-tetrahydrofuran-3-yl ((2S,3R)-4-((4-(1,3-dioxoisoindolin-2-yl)-N-isobutylphenyl)sulfonamido)-3-hydroxy-1-phenylbutan-2-yl)carbamate |
| FOSAC-022 | 1333313-45-3 | (S)-tetrahydrofuran-3-yl ((2S,3R)-4-((4-(1,3-dioxoisoindolin-2-yl)-N-isobutylphenyl)sulfonamido)-1-phenyl-3-(phosphonooxy)butan-2-yl)carbamate |
OptimisedRoute 5Steps 8 · Total yield 0.04 g
FOSAC-00798-74-8FOSAC-008160231-69-6FOSAC-02342238-15-3FOSAC-02485531-71-1FOSAC-0251824396-02-2FOSAC-0261824298-01-2FOSAC-027188264-84-8FOSAC-028136465-89-9FOSAC-029206361-96-8FOSAC-0301394027-31-6FOSAC-031187946-12-9FOSAC-032—API · Fosamprenavir Calcium
| Code | CAS No. | Intermediate |
|---|---|---|
| FOSAC-007 | 98-74-8 | 4-nitrobenzenesulfonyl chloride |
| FOSAC-008 | 160231-69-6 | (S)-tetrahydrofuran-3-yl ((2S,3R)-3-hydroxy-4-(N-isobutyl-4-nitrophenylsulfonamido)-1-phenylbutan-2-yl)carbamate |
| FOSAC-023 | 42238-15-3 | (E)-4-phenylbut-2-en-1-ol |
| FOSAC-024 | 85531-71-1 | (3-benzyloxiran-2-yl)methanol |
| FOSAC-025 | 1824396-02-2 | 3-azido-4-phenylbutane-1,2-diol |
| FOSAC-026 | 1824298-01-2 | 2-(1-azido-2-phenylethyl)oxirane |
| FOSAC-027 | 188264-84-8 | Cobalt, [[2,2'-[(1S,2S)-1,2-cyclohexanediylbis[(nitrilo-kN)methylidyne]]bis[4,6-bis(1,1-dimethylethyl)phenolato-kO]](2-)]-, (SP-4-2)- |
| FOSAC-028 | 136465-89-9 | (S)-2-((S)-1-azido-2-phenylethyl)oxirane |
| FOSAC-029 | 206361-96-8 | (2R,3S)-3-azido-1-(isobutylamino)-4-phenylbutan-2-ol |
| FOSAC-030 | 1394027-31-6 | N-((2R,3S)-3-azido-2-hydroxy-4-phenylbutyl)-N-isobutyl-4-nitrobenzenesulfonamide |
| FOSAC-031 | 187946-12-9 | (S)-tetrahydrofuran-3-yl 2,5-dioxopyrrolidine-1-carboxylate |
| FOSAC-032 | - | (S)-tetrahydrofuran-3-yl ((2S,3R)-4-((4-amino-N-isobutylphenyl)sulfonamido)-3-hydroxy-1-phenylbutan-2-yl)carbamate |
Frequently asked questions
What are the approved indications of Fosamprenavir Calcium?
Approved indications include: HIV infection.
When does the Fosamprenavir Calcium patent expire?
No public expiry year is available for Fosamprenavir Calcium yet; this page updates once verified.
How many synthesis routes are recorded for Fosamprenavir Calcium?
5 synthesis routes are recorded; the shortest is 4 steps with 25.8 kg total yield. Intermediates in each route carry codes and CAS numbers.
Where can I buy Fosamprenavir Calcium intermediates?
All intermediates in Fosamprenavir Calcium routes have CAS profiles — you can submit an RFQ per CAS and it enters the Unibest matching pool.
How do I get a quote for Fosamprenavir Calcium intermediates?
Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.
Source: cross-verified data (structured fields only) · 2026-09-29