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Alectinib Hydrochloride

Tier B — Position early

Alectinib Hydrochloride · all drugs expiring in 2030 →

Chugai Pharmaceutical Co., Ltd.
Originator
2014
First approval
2030
Expiry (public)
$1.89B ▲
Peak sales
Small molecule
Type

Targets：ALK, RET

Brand：Alecensa, Alecensaro

Indications (approved)：Non-small cell lung cancer, Lung cancer

Regional status

US
Approved
2015-12-11
EU
Approved
2017-02-16
China
Approved
2018-08-12
Japan
Approved
2014-07-04

Factories producing this API1

Factories registered as producing this API in our sourcing network (RFQ records + product master), sorted by RFQ activity; the snapshot carries no cost or customer data.

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Synthetic routes & intermediates3 routes

Originator routes × 1Optimised (non-patent) × 2Process routes × 0

Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.

OriginatorRoute 1Steps 10 · Total yield /
Synthetic routes & intermediates Route 1
CodeCAS No.Intermediate
ALEC-0014133-34-0Available7-methoxy-3,4-dihydronaphthalen-2(1H)-one
ALEC-0021865-83-4Available7-methoxy-1,1-dimethyl-3,4-dihydronaphthalen-2(1H)-one
ALEC-0031256578-99-0Available6-bromo-7-methoxy-1,1-dimethyl-3,4-dihydronaphthalen-2(1H)-one
ALEC-00417672-26-3Available3-hydrazinylbenzonitrile
ALEC-0051256579-00-6Available9-bromo-8-methoxy-6,6-dimethyl-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile
ALEC-0061256579-03-9Available9-bromo-8-methoxy-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile
ALEC-0071256579-06-2Available9-bromo-8-hydroxy-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile
ALEC-0081256579-48-2Available9-bromo-3-cyano-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazol-8-yl trifluoromethanesulfonate
ALEC-00953617-35-9Available4-(piperidin-4-yl)morpholine
ALEC-0101256579-62-0Available9-bromo-6,6-dimethyl-8-(4-morpholinopiperidin-1-yl)-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile
ALEC-01189343-06-6Availableethynyltriisopropylsilane
ALEC-0121256580-24-1Available9-ethynyl-6,6-dimethyl-8-(4-morpholinopiperidin-1-yl)-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile
OptimisedRoute 2Steps 9 · Total yield 357 g
Synthetic routes & intermediates Route 2
CodeCAS No.Intermediate
ALEC-00953617-35-9Available4-(piperidin-4-yl)morpholine
ALEC-01332454-35-6Available2-(4-bromophenyl)-2-methylpropanoic acid
ALEC-01413682-77-4Availablepotassium trifluoro(vinyl)borate
ALEC-0151256584-72-1Available2-methyl-2-(4-vinylphenyl)propanoic acid
ALEC-0161247119-83-0Available2-(4-ethylphenyl)-2-methylpropanoic acid
ALEC-0171256584-73-2Available2-(4-ethyl-3-iodophenyl)-2-methylpropanoic acid
ALEC-01840052-13-9Available3-(tert-butoxy)-3-oxopropanoic acid
ALEC-0191256584-74-3Availabletert-butyl 4-(4-ethyl-3-iodophenyl)-4-methyl-3-oxopentanoate
ALEC-020939-80-0Available4-chloro-3-nitrobenzonitrile
ALEC-0211256584-75-4Availabletert-butyl 6-cyano-2-(2-(4-ethyl-3-iodophenyl)propan-2-yl)-1H-indole-3-carboxylate
ALEC-0221256698-41-5Availabletert-butyl 6-cyano-2-(2-(4-ethyl-3-(4-morpholinopiperidin-1-yl)phenyl)propan-2-yl)-1H-indole-3-carboxylate hydrochloride
ALEC-0231256584-78-7Available6-cyano-2-(2-(4-ethyl-3-(4-morpholinopiperidin-1-yl)phenyl)propan-2-yl)-1H-indole-3-carboxylic acid
OptimisedRoute 3Steps 6 · Total yield 2.1 g
Synthetic routes & intermediates Route 3
CodeCAS No.Intermediate
ALEC-00953617-35-9Available4-(piperidin-4-yl)morpholine
ALEC-0231256584-78-7Available6-cyano-2-(2-(4-ethyl-3-(4-morpholinopiperidin-1-yl)phenyl)propan-2-yl)-1H-indole-3-carboxylic acid
ALEC-02490841-42-2Available1-(3-bromo-4-ethylphenyl)ethanone
ALEC-0251675897-35-4Available1-(4-ethyl-3-(4-morpholinopiperidin-1-yl)phenyl)ethanone
ALEC-0261675897-39-8Available2-(4-ethyl-3-(4-morpholinopiperidin-1-yl)phenyl)propan-2-ol
ALEC-0271357147-38-6Availablemethyl 6-cyano-1H-indole-3-carboxylate
ALEC-0281675897-18-3Availablemethyl 6-cyano-2-(2-(4-ethyl-3-(4-morpholinopiperidin-1-yl)phenyl)propan-2-yl)-1H-indole-3-carboxylate
ALEC-02915861-36-6Available1H-indole-6-carbonitrile
ALEC-03076-02-8Available2,2,2-trichloroacetyl chloride

Frequently asked questions

What are the approved indications of Alectinib Hydrochloride?

Approved indications include: Non-small cell lung cancer, Lung cancer.

When does the Alectinib Hydrochloride patent expire?

Based on public sources, the Alectinib Hydrochloride patent expires in 2030.

How many synthesis routes are recorded for Alectinib Hydrochloride?

3 synthesis routes are recorded; the shortest is 6 steps with 2.1 g total yield. Intermediates in each route carry codes and CAS numbers.

Where can I buy Alectinib Hydrochloride intermediates?

30 intermediate CAS of Alectinib Hydrochloride are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.

How do I get a quote for Alectinib Hydrochloride intermediates?

Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.

Source: cross-verified data (structured fields only) · 2026-09-29