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Ruxolitinib Phosphate

Tier A — Act now

Ruxolitinib Phosphate · all drugs expiring in 2028 →

Incyte Corp
Originator
2011
First approval
2028
Expiry (public)
$5.88B ▲
Peak sales
Small molecule
Type

Targets：JAK2, JAK1

Brand：OPZELURA, Jakafi, Jakavi

Indications (approved)：Atopic dermatitis, Vitiligo, Graft-versus-host disease, Myelofibrosis, Polycythaemia vera

Regional status

US
Approved
2011-11-16
EU
Approved
2012-08-23
China
Approved
2017-03-10
Japan
Approved
2014-07-04

Factories producing this API1

Factories registered as producing this API in our sourcing network (RFQ records + product master), sorted by RFQ activity; the snapshot carries no cost or customer data.

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Synthetic routes & intermediates4 routes

Originator routes × 1Optimised (non-patent) × 3Process routes × 0

Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.

OriginatorRoute 1Steps 5 · Total yield 171.7 mg
Synthetic routes & intermediates Route 1
CodeCAS No.Intermediate
RUXO-0013680-69-1Available4-chloro-7H-pyrrolo[2,3-d]pyrimidine
RUXO-002941685-26-3Available4-chloro-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidine
RUXO-003269410-08-4Available4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole
RUXO-004941685-27-4Available4-(1H-pyrazol-4-yl)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidine
RUXO-005591769-05-0Available3-cyclopentylacrylonitrile
RUXO-006941685-40-1Available(R)-3-cyclopentyl-3-(4-(7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)propanenitrile
OptimisedRoute 2Steps 9 · Total yield 634.2 g
Synthetic routes & intermediates Route 2
CodeCAS No.Intermediate
RUXO-0013680-69-1Available4-chloro-7H-pyrrolo[2,3-d]pyrimidine
RUXO-0071146629-75-5Available(4-chloro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl pivalate
RUXO-0081029716-44-6Available1-(1-ethoxyethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole
RUXO-0091146629-76-6Available(4-(1-(1-ethoxyethyl)-1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl pivalate
RUXO-0101146629-77-7Available(4-(1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl pivalate
RUXO-011941685-68-3Available3-cyclopentylpropiolonitrile
RUXO-0121236033-17-2Available(Z)-(4-(1-(2-cyano-1-cyclopentylvinyl)-1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl pivalate
RUXO-0131236033-18-3Available(Z)-(4-(1-(3-amino-1-cyclopentyl-3-oxoprop-1-en-1-yl)-1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl pivalate
RUXO-0141236032-96-4Available(R)-(4-(1-(3-amino-1-cyclopentyl-3-oxopropyl)-1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl pivalate
RUXO-0151146629-80-2Available(R)-(4-(1-(2-cyano-1-cyclopentylethyl)-1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl pivalate
OptimisedRoute 3Steps 4 · Total yield /
Synthetic routes & intermediates Route 3
CodeCAS No.Intermediate
RUXO-0101146629-77-7Available(4-(1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl pivalate
RUXO-0151146629-80-2Available(R)-(4-(1-(2-cyano-1-cyclopentylethyl)-1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl pivalate
RUXO-016872-53-7Availablecyclopentanecarbaldehyde
RUXO-0172136-75-6Available2-(triphenylphosphoranylidene)acetaldehyde
RUXO-018118235-51-1Available(E)-3-cyclopentylacrylaldehyde
RUXO-0191146629-79-9Available(R)-(4-(1-(1-cyclopentyl-3-oxopropyl)-1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl pivalate
OptimisedRoute 4Steps 4 · Total yield 204.3 mg
Synthetic routes & intermediates Route 4
CodeCAS No.Intermediate
RUXO-0013680-69-1Available4-chloro-7H-pyrrolo[2,3-d]pyrimidine
RUXO-018118235-51-1Available(E)-3-cyclopentylacrylaldehyde
RUXO-0202075-45-8Available4-bromo-1H-pyrazole
RUXO-0211146629-82-4Available(R)-3-(4-bromo-1H-pyrazol-1-yl)-3-cyclopentylpropanal
RUXO-0221146629-83-5Available(R)-3-(4-bromo-1H-pyrazol-1-yl)-3-cyclopentylpropanenitrile
RUXO-02373183-34-3Available4,4,4',4',5,5,5',5'-octamethyl-2,2'-bi(1,3,2-dioxaborolane)
RUXO-0241146629-84-6Available(R)-3-cyclopentyl-3-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)propanenitrile

Frequently asked questions

What are the approved indications of Ruxolitinib Phosphate?

Approved indications include: Atopic dermatitis, Vitiligo, Graft-versus-host disease, Myelofibrosis, Polycythaemia vera.

When does the Ruxolitinib Phosphate patent expire?

Based on public sources, the Ruxolitinib Phosphate patent expires in 2028.

How many synthesis routes are recorded for Ruxolitinib Phosphate?

4 synthesis routes are recorded; the shortest is 4 steps with / total yield. Intermediates in each route carry codes and CAS numbers.

Where can I buy Ruxolitinib Phosphate intermediates?

24 intermediate CAS of Ruxolitinib Phosphate are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.

How do I get a quote for Ruxolitinib Phosphate intermediates?

Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.

Source: cross-verified data (structured fields only) · 2026-09-29