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Irbesartan/Trichlormethiazide
Tier C — Watch / tradeIrbesartan/Trichlormethiazide
Shionogi & Co., Ltd.
Originator
2013
First approval
-
Expiry (public)
No sales data
Peak sales
Small molecule
Type
Targets：Thiazide-sensitive sodium-chloride cotransporter, AT1
Brand：Irtra
Indications (approved)：Hypertension
Regional status
US
-
EU
-
China
-
Japan
Approved
2013-06-28
Factories producing this API10
Factories registered as producing this API in our sourcing network (RFQ records + product master), sorted by RFQ activity; the snapshot carries no cost or customer data.
10 producing factories on file — sign in to view the named list (factory details are not shown to guests).
Sign in to view factories →Synthetic routes & intermediates7 routes
Originator routes × 1Optimised (non-patent) × 6Process routes × 0
Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.
OriginatorRoute 1Steps 6 · Total yield 1.42 g
IRBE-0011664-35-3IRBE-002999-09-7IRBE-003138402-05-8IRBE-004114772-54-2IRBE-005138401-24-8IRBE-00657598-33-1IRBE-0074294-57-9IRBE-00884392-32-5IRBE-009114772-53-1API · Irbesartan/Trichlormethiazide
| Code | CAS No. | Intermediate |
|---|---|---|
| IRBE-001 | 1664-35-3 | ethyl 1-aminocyclopentane-1-carboxylate |
| IRBE-002 | 999-09-7 | ethyl pentanimidate |
| IRBE-003 | 138402-05-8Available | 2-butyl-1,3-diazaspiro[4.4]non-1-en-4-one |
| IRBE-004 | 114772-54-2 | 4'-(bromomethyl)-[1,1'-biphenyl]-2-carbonitrile |
| IRBE-005 | 138401-24-8 | 4'-((2-butyl-4-oxo-1,3-diazaspiro[4.4]non-1-en-3-yl)methyl)-[1,1'-biphenyl]-2-carbonitrile |
| IRBE-006 | 57598-33-1 | 2-(2-methoxyphenyl)-4,4-dimethyl-4,5-dihydrooxazole |
| IRBE-007 | 4294-57-9 | p-tolylmagnesium bromide |
| IRBE-008 | 84392-32-5 | 4,4-dimethyl-2-(4'-methyl-[1,1'-biphenyl]-2-yl)-4,5-dihydrooxazole |
| IRBE-009 | 114772-53-1 | 4'-methyl-[1,1'-biphenyl]-2-carbonitrile |
OptimisedRoute 2Steps 5 · Total yield 380.00 mg
IRBE-010106-37-6IRBE-0111122-91-4IRBE-012873-75-6IRBE-013589-15-1IRBE-014151257-01-1IRBE-015731851-41-5IRBE-016144873-97-2API · Irbesartan/Trichlormethiazide
| Code | CAS No. | Intermediate |
|---|---|---|
| IRBE-010 | 106-37-6Available | 1,4-dibromobenzene |
| IRBE-011 | 1122-91-4 | 4-bromobenzaldehyde |
| IRBE-012 | 873-75-6 | (4-bromophenyl)methanol |
| IRBE-013 | 589-15-1 | 1-bromo-4-(bromomethyl)benzene |
| IRBE-014 | 151257-01-1 | 2-butyl-1,3-diazaspiro[4.4]non-1-en-4-one hydrochloride |
| IRBE-015 | 731851-41-5 | 3-(4-bromobenzyl)-2-butyl-1,3-diazaspiro[4.4]non-1-en-4-one |
| IRBE-016 | 144873-97-2 | (2-(1-trityl-1H-tetrazol-5-yl)phenyl)boronic acid |
OptimisedRoute 3Steps 3 · Total yield 1.83 g
IRBE-01715026-80-9IRBE-01859528-27-7IRBE-019908117-90-8IRBE-020908227-87-2IRBE-021155884-01-8API · Irbesartan/Trichlormethiazide
| Code | CAS No. | Intermediate |
|---|---|---|
| IRBE-017 | 15026-80-9 | 1-pentanamidocyclopentane-1-carboxylic acid |
| IRBE-018 | 59528-27-7 | (4-iodophenyl)methanamine hydrochloride |
| IRBE-019 | 908117-90-8 | N-(4-iodobenzyl)-1-pentanamidocyclopentane-1-carboxamide |
| IRBE-020 | 908227-87-2 | 2-butyl-3-(4-iodobenzyl)-1,3-diazaspiro[4.4]non-1-en-4-one |
| IRBE-021 | 155884-01-8 | (2-(1H-tetrazol-5-yl)phenyl)boronic acid |
OptimisedRoute 4Steps 4 · Total yield 1.05 g
IRBE-004114772-54-2IRBE-005138401-24-8IRBE-02217193-28-1IRBE-023638-29-9IRBE-024177219-40-8IRBE-025141745-71-3API · Irbesartan/Trichlormethiazide
| Code | CAS No. | Intermediate |
|---|---|---|
| IRBE-004 | 114772-54-2 | 4'-(bromomethyl)-[1,1'-biphenyl]-2-carbonitrile |
| IRBE-005 | 138401-24-8 | 4'-((2-butyl-4-oxo-1,3-diazaspiro[4.4]non-1-en-3-yl)methyl)-[1,1'-biphenyl]-2-carbonitrile |
| IRBE-022 | 17193-28-1 | 1-aminocyclopentane-1-carboxamide |
| IRBE-023 | 638-29-9 | pentanoyl chloride |
| IRBE-024 | 177219-40-8 | 1-pentanamidocyclopentane-1-carboxamide |
| IRBE-025 | 141745-71-3 | N-((2'-cyano-[1,1'-biphenyl]-4-yl)methyl)-1-pentanamidocyclopentane-1-carboxamide |
OptimisedRoute 5Steps 5 · Total yield /
IRBE-005138401-24-8IRBE-01715026-80-9IRBE-023638-29-9IRBE-026120-92-3IRBE-02749830-37-7IRBE-02892398-48-6IRBE-029133690-92-3API · Irbesartan/Trichlormethiazide
| Code | CAS No. | Intermediate |
|---|---|---|
| IRBE-005 | 138401-24-8 | 4'-((2-butyl-4-oxo-1,3-diazaspiro[4.4]non-1-en-3-yl)methyl)-[1,1'-biphenyl]-2-carbonitrile |
| IRBE-017 | 15026-80-9 | 1-pentanamidocyclopentane-1-carboxylic acid |
| IRBE-023 | 638-29-9 | pentanoyl chloride |
| IRBE-026 | 120-92-3 | cyclopentanone |
| IRBE-027 | 49830-37-7 | 1-aminocyclopentane-1-carbonitrile |
| IRBE-028 | 92398-48-6 | 1-aminocyclopentane-1-carboxylic acid hydrochloride |
| IRBE-029 | 133690-92-3 | 4'-(aminomethyl)-[1,1'-biphenyl]-2-carbonitrile |
OptimisedRoute 1Steps 8 · Total yield /
Trichlormethiazide-001—Trichlormethiazide-002—Trichlormethiazide-003—Trichlormethiazide-004—Trichlormethiazide-00590003-74-0Trichlormethiazide-0062904-45-2Trichlormethiazide-007—Trichlormethiazide-008861067-16-5Trichlormethiazide-009—Trichlormethiazide-010—Trichlormethiazide-011—Trichlormethiazide-012—API · Irbesartan/Trichlormethiazide
| Code | CAS No. | Intermediate |
|---|---|---|
| Trichlormethiazide-001 | - | 4-Amino-6-chlorobenzene-1,3-disulfonyl dichloride |
| Trichlormethiazide-002 | - | 2,2-Dichloroacetic acid chloride |
| Trichlormethiazide-003 | - | Dichloroacetic anhydride |
| Trichlormethiazide-004 | - | 4-Chloro-6-(2,2-dichloroacetamido)benzene-1,3-disulfonyl dichloride |
| Trichlormethiazide-005 | 90003-74-0 | 2,2-Dichloro-N-(5-chloro-2,4-disulfamoylphenyl)acetamide |
| Trichlormethiazide-006 | 2904-45-2 | 6-Chloro-3-(dichloromethyl)-1,1-dioxo-1,2-dihydro-1lambda6,2,4-benzothiadiazine-7-sulfonamide |
| Trichlormethiazide-007 | - | 2,2-Dichloroacetonitrile |
| Trichlormethiazide-008 | 861067-16-5 | Ethyl 2,2-dichloroethanimidoate hydrochloride |
| Trichlormethiazide-009 | - | 2,2-Dichloro-1,1,1-triethoxyethane |
| Trichlormethiazide-010 | - | 4-Amino-6-chlorobenzene-1,3-disulfonamide |
| Trichlormethiazide-011 | - | Dichloroacetaldehyde |
| Trichlormethiazide-012 | - | 1,1-Dichloro-2,2-diethoxyethane |
OptimisedRoute 2Steps 2 · Total yield /
Trichlormethiazide-001—Trichlormethiazide-011—Trichlormethiazide-013—API · Irbesartan/Trichlormethiazide
| Code | CAS No. | Intermediate |
|---|---|---|
| Trichlormethiazide-001 | - | 4-Amino-6-chlorobenzene-1,3-disulfonyl dichloride |
| Trichlormethiazide-011 | - | Dichloroacetaldehyde |
| Trichlormethiazide-013 | - | 4-Chloro-6-[(E)-(2,2-dichloroethylidene)amino]benzene-1,3-disulfonyl dichloride |
Frequently asked questions
What are the approved indications of Irbesartan/Trichlormethiazide?
Approved indications include: Hypertension.
When does the Irbesartan/Trichlormethiazide patent expire?
No public expiry year is available for Irbesartan/Trichlormethiazide yet; this page updates once verified.
How many synthesis routes are recorded for Irbesartan/Trichlormethiazide?
7 synthesis routes are recorded; the shortest is 2 steps with / total yield. Intermediates in each route carry codes and CAS numbers.
Where can I buy Irbesartan/Trichlormethiazide intermediates?
2 intermediate CAS of Irbesartan/Trichlormethiazide are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.
How do I get a quote for Irbesartan/Trichlormethiazide intermediates?
Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.
Source: cross-verified data (structured fields only) · 2026-09-29