← Back to patent-cliff list
Censavudine
Tier C — Watch / tradeCensavudine
-
Originator
-
First approval
-
Expiry (public)
No sales data
Peak sales
Small molecule
Type
Targets：HIV-1 RT
Indications (approved)：进行性核上性麻痹, Frontotemporal dementia, Amyotrophic lateral sclerosis, Aicardi综合征, HIV infection
Regional status
US
Phase II
2011-02-01
EU
Phase II
2011-02-01
China
-
Japan
-
Synthetic routes & intermediates4 routes
Originator routes × 1Optimised (non-patent) × 3Process routes × 0
Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.
OriginatorRoute 1Steps 8 · Total yield 275 mg
CENSA-0011463-10-1CENSA-0021631050-03-7CENSA-00314002-51-8CENSA-0041631050-04-8CENSA-0051631050-05-9CENSA-0061631050-06-0CENSA-0071631050-07-1CENSA-0081631050-08-2CENSA-0091631050-09-3Censavudine634907-30-5API · Censavudine
| Code | CAS No. | Intermediate |
|---|---|---|
| CENSA-001 | 1463-10-1 | 1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione |
| CENSA-002 | 1631050-03-7 | 1-((3aR,4R,6R,6aR)-6-(hydroxymethyl)-2-methyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)-5-methylpyrimidine-2,4(1H,3H)-dione |
| CENSA-003 | 14002-51-8 | [1,1'-biphenyl]-4-carbonyl chloride |
| CENSA-004 | 1631050-04-8 | ((3aR,4R,6R,6aR)-2-methyl-6-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl [1,1'-biphenyl]-4-carboxylate |
| CENSA-005 | 1631050-05-9 | ((2R,3R,4R,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-(vinyloxy)tetrahydrofuran-2-yl)methyl [1,1'-biphenyl]-4-carboxylate |
| CENSA-006 | 1631050-06-0 | ((2R,3S,4S,5R)-3-iodo-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-(vinyloxy)tetrahydrofuran-2-yl)methyl [1,1'-biphenyl]-4-carboxylate |
| CENSA-007 | 1631050-07-1 | ((4R,5R)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-(vinyloxy)-4,5-dihydrofuran-2-yl)methyl [1,1'-biphenyl]-4-carboxylate |
| CENSA-008 | 1631050-08-2 | ((2S,5R)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2-(2-oxoethyl)-2,5-dihydrofuran-2-yl)methyl [1,1'-biphenyl]-4-carboxylate |
| CENSA-009 | 1631050-09-3 | ((2R,5R)-2-ethynyl-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2,5-dihydrofuran-2-yl)methyl [1,1'-biphenyl]-4-carboxylate |
| Censavudine | 634907-30-5 | 1-((2R,5R)-5-ethynyl-5-(hydroxymethyl)-2,5-dihydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione |
OptimisedRoute 2Steps 8 · Total yield /
CENSA-01098-00-0CENSA-01162644-49-9CENSA-012188670-22-6CENSA-0131170661-01-4CENSA-0141170661-03-6CENSA-0151170661-04-7CENSA-01665-71-4CENSA-0171170661-05-8CENSA-018—Censavudine634907-30-5API · Censavudine
| Code | CAS No. | Intermediate |
|---|---|---|
| CENSA-010 | 98-00-0 | furan-2-ylmethanol |
| CENSA-011 | 62644-49-9 | 5-oxo-5,6-dihydro-2H-pyran-2-yl acetate |
| CENSA-012 | 188670-22-6 | (S)-5-oxo-5,6-dihydro-2H-pyran-2-yl acetate |
| CENSA-013 | 1170661-01-4 | (2S,5S)-5-hydroxy-5-((trimethylsilyl)ethynyl)-5,6-dihydro-2H-pyran-2-yl acetate |
| CENSA-014 | 1170661-03-6 | (5R)-5-(hydroxymethyl)-5-((trimethylsilyl)ethynyl)-2,5-dihydrofuran-2-ol |
| CENSA-015 | 1170661-04-7 | ((2R)-5-acetoxy-2-((trimethylsilyl)ethynyl)-2,5-dihydrofuran-2-yl)methyl acetate |
| CENSA-016 | 65-71-4 | 5-methylpyrimidine-2,4(1H,3H)-dione |
| CENSA-017 | 1170661-05-8 | ((2R)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2-((trimethylsilyl)ethynyl)-2,5-dihydrofuran-2-yl)methyl acetate |
| CENSA-018 | - | 1-((5R)-5-ethynyl-5-(hydroxymethyl)-2,5-dihydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione |
| Censavudine | 634907-30-5 | 1-((2R,5R)-5-ethynyl-5-(hydroxymethyl)-2,5-dihydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione |
OptimisedRoute 3Steps 13 · Total yield 0.26 g
CENSA-01665-71-4CENSA-019108-21-4CENSA-020107-02-8CENSA-021122763-66-0CENSA-022943856-40-4CENSA-023943856-51-7CENSA-024943856-41-5CENSA-025943856-42-6CENSA-0264301-14-8CENSA-027—CENSA-028943856-44-8CENSA-029943856-45-9CENSA-030—CENSA-031221272-62-4CENSA-032943856-52-8CENSA-033943856-49-3Censavudine634907-30-5API · Censavudine
| Code | CAS No. | Intermediate |
|---|---|---|
| CENSA-016 | 65-71-4 | 5-methylpyrimidine-2,4(1H,3H)-dione |
| CENSA-019 | 108-21-4Available | isopropyl acetate |
| CENSA-020 | 107-02-8 | acrylaldehyde |
| CENSA-021 | 122763-66-0 | isopropyl 3-hydroxypent-4-enoate |
| CENSA-022 | 943856-40-4 | isopropyl 3-(methoxymethoxy)pent-4-enoate |
| CENSA-023 | 943856-51-7 | isopropyl 4,5-dihydroxy-3-(methoxymethoxy)pentanoate |
| CENSA-024 | 943856-41-5 | isopropyl 5-((tert-butyldimethylsilyl)oxy)-4-hydroxy-3-(methoxymethoxy)pentanoate |
| CENSA-025 | 943856-42-6 | isopropyl 5-((tert-butyldimethylsilyl)oxy)-3-(methoxymethoxy)-4-oxopentanoate |
| CENSA-026 | 4301-14-8 | ethynylmagnesium bromide |
| CENSA-027 | - | isopropyl (3S,4R)-4-(((tert-butyldimethylsilyl)oxy)methyl)-4-hydroxy-3-(methoxymethoxy)hex-5-ynoate |
| CENSA-028 | 943856-44-8 | (4S,5R)-5-(((tert-butyldimethylsilyl)oxy)methyl)-5-ethynyl-4-(methoxymethoxy)tetrahydrofuran-2-ol |
| CENSA-029 | 943856-45-9 | (4S,5R)-5-(((tert-butyldimethylsilyl)oxy)methyl)-5-ethynyl-4-(methoxymethoxy)tetrahydrofuran-2-yl acetate |
| CENSA-030 | - | 1-((2R,4S,5R)-5-(((tert-butyldimethylsilyl)oxy)methyl)-5-ethynyl-4-(methoxymethoxy)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione |
| CENSA-031 | 221272-62-4 | 1-((2R,4S,5R)-5-ethynyl-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione |
| CENSA-032 | 943856-52-8 | 1-((2R,4S,5R)-5-(((tert-butyldimethylsilyl)oxy)methyl)-5-ethynyl-4-hydroxytetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione |
| CENSA-033 | 943856-49-3 | (2R,3S,5R)-2-(((tert-butyldimethylsilyl)oxy)methyl)-2-ethynyl-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl methanesulfonate |
| Censavudine | 634907-30-5 | 1-((2R,5R)-5-ethynyl-5-(hydroxymethyl)-2,5-dihydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione |
OptimisedRoute 4Steps 9 · Total yield /
CENSA-03435436-57-8CENSA-035582302-77-0CENSA-036106-45-6CENSA-0371498325-15-7CENSA-03854655-07-1CENSA-0391498325-08-8CENSA-0401498325-19-1CENSA-0411498325-23-7CENSA-0421498325-10-2CENSA-0437288-28-0CENSA-0441498325-12-4CENSA-045744217-17-2Censavudine634907-30-5API · Censavudine
| Code | CAS No. | Intermediate |
|---|---|---|
| CENSA-034 | 35436-57-8 | 6-hydroxy-2H-pyran-3(6H)-one |
| CENSA-035 | 582302-77-0 | (S)-5-oxo-5,6-dihydro-2H-pyran-2-yl benzoate |
| CENSA-036 | 106-45-6 | 4-methylbenzenethiol |
| CENSA-037 | 1498325-15-7 | (2S,3R)-5-oxo-3-(p-tolylthio)tetrahydro-2H-pyran-2-yl benzoate |
| CENSA-038 | 54655-07-1 | ((trimethylsilyl)ethynyl)lithium |
| CENSA-039 | 1498325-08-8 | (2S,3R,5R)-5-hydroxy-3-(p-tolylthio)-5-((trimethylsilyl)ethynyl)tetrahydro-2H-pyran-2-yl benzoate |
| CENSA-040 | 1498325-19-1 | (3R,5R)-5-(hydroxymethyl)-3-(p-tolylthio)-5-((trimethylsilyl)ethynyl)tetrahydrofuran-2-ol |
| CENSA-041 | 1498325-23-7 | ((2R,4R,5R)-5-(benzoyloxy)-4-(p-tolylthio)-2-((trimethylsilyl)ethynyl)tetrahydrofuran-2-yl)methyl benzoate |
| CENSA-042 | 1498325-10-2 | ((2R,4R,5R)-5-(benzoyloxy)-2-ethynyl-4-(p-tolylthio)tetrahydrofuran-2-yl)methyl benzoate |
| CENSA-043 | 7288-28-0 | 5-methyl-2,4-bis((trimethylsilyl)oxy)pyrimidine |
| CENSA-044 | 1498325-12-4 | ((2R,4R,5R)-2-ethynyl-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-(p-tolylthio)tetrahydrofuran-2-yl)methyl benzoate |
| CENSA-045 | 744217-17-2 | ((2R,5R)-2-ethynyl-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2,5-dihydrofuran-2-yl)methyl benzoate |
| Censavudine | 634907-30-5 | 1-((2R,5R)-5-ethynyl-5-(hydroxymethyl)-2,5-dihydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione |
Frequently asked questions
What are the approved indications of Censavudine?
Approved indications include: 进行性核上性麻痹, Frontotemporal dementia, Amyotrophic lateral sclerosis, Aicardi综合征, HIV infection.
When does the Censavudine patent expire?
No public expiry year is available for Censavudine yet; this page updates once verified.
How many synthesis routes are recorded for Censavudine?
4 synthesis routes are recorded; the shortest is 8 steps with 275 mg total yield. Intermediates in each route carry codes and CAS numbers.
Where can I buy Censavudine intermediates?
1 intermediate CAS of Censavudine are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.
How do I get a quote for Censavudine intermediates?
Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.
Source: cross-verified data (structured fields only) · 2026-10-19