Tulobuterol

Tier C — Watch / trade

Tulobuterol

Hokuriku Seiyaku Co Ltd

Originator

1998

First approval

Expiry (public)

No sales data

Peak sales

Small molecule

Type

Targets：ADRB2

Brand：Hokunalin

Indications (approved)：Acute respiratory distress syndrome, 肺气肿, Acute bronchitis, Chronic bronchitis, Asthma

Regional status

China

Approved

2006-11-22

Japan

Approved

1998-09-30

Synthetic routes & intermediates3 routes

Originator routes × 0Optimised (non-patent) × 3Process routes × 0

Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.

OptimisedRoute 1Steps 2 · Total yield 14.8g(Tulobuterol (Free))

Tulobuterol Hydrochloride-001—Tulobuterol Hydrochloride-00227993-71-1Tulobuterol Hydrochloride-003—Tulobuterol Hydrochloride-004—API · Tulobuterol

Code	CAS No.	Intermediate
Tulobuterol Hydrochloride-001	-	1-(2-Chlorophenyl)ethanone
Tulobuterol Hydrochloride-002	27993-71-1	2-(2-chlorophenyl)-2-oxoacetaldehyde
Tulobuterol Hydrochloride-003	-	1,1-Dimethylethylamine
Tulobuterol Hydrochloride-004	-	2-(tert-Butylamino)-1-(2-chlorophenyl)ethan-1-ol

OptimisedRoute 2Steps 4 · Total yield 82g(Tulobuterol (Free))

Tulobuterol Hydrochloride-005—Tulobuterol Hydrochloride-006—Tulobuterol Hydrochloride-007—Tulobuterol Hydrochloride-008—Tulobuterol Hydrochloride-009—Tulobuterol Hydrochloride-003—Tulobuterol Hydrochloride-004—API · Tulobuterol

Code	CAS No.	Intermediate
Tulobuterol Hydrochloride-005	-	1-(2-Chlorophenyl)ethanol
Tulobuterol Hydrochloride-006	-	1-Chloro-2-ethenylbenzene
Tulobuterol Hydrochloride-007	-	1-Chloro-2-(epoxyethyl)-benzene
Tulobuterol Hydrochloride-008	-	2-Chlorobenzaldehyde
Tulobuterol Hydrochloride-009	-	Trimethylsulfonium iodide
Tulobuterol Hydrochloride-003	-	1,1-Dimethylethylamine
Tulobuterol Hydrochloride-004	-	2-(tert-Butylamino)-1-(2-chlorophenyl)ethan-1-ol

OptimisedRoute 3Steps 2 · Total yield 14.9(Tulobuterol (Free))

Tulobuterol Hydrochloride-006—Tulobuterol Hydrochloride-01272702-57-9Tulobuterol Hydrochloride-003—Tulobuterol Hydrochloride-004—API · Tulobuterol

Code	CAS No.	Intermediate
Tulobuterol Hydrochloride-006	-	1-Chloro-2-ethenylbenzene
Tulobuterol Hydrochloride-012	72702-57-9	2-Bromo-1-(2-chlorophenyl)ethan-1-ol
Tulobuterol Hydrochloride-003	-	1,1-Dimethylethylamine
Tulobuterol Hydrochloride-004	-	2-(tert-Butylamino)-1-(2-chlorophenyl)ethan-1-ol

Frequently asked questions

What are the approved indications of Tulobuterol?

Approved indications include: Acute respiratory distress syndrome, 肺气肿, Acute bronchitis, Chronic bronchitis, Asthma.

When does the Tulobuterol patent expire?

No public expiry year is available for Tulobuterol yet; this page updates once verified.

How many synthesis routes are recorded for Tulobuterol?

3 synthesis routes are recorded; the shortest is 2 steps with 14.8g(Tulobuterol (Free)) total yield. Intermediates in each route carry codes and CAS numbers.

Where can I buy Tulobuterol intermediates?

All intermediates in Tulobuterol routes have CAS profiles — you can submit an RFQ per CAS and it enters the Unibest matching pool.

How do I get a quote for Tulobuterol intermediates?

Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.

Source: cross-verified data (structured fields only) · 2026-09-29