Betamethasone/Clotrimazole/Gentamicin Sulfate

Tier C — Watch / trade

Chang'ao (Hong Kong) Holdings Limited

Originator

2016

First approval

Expiry (public)

No sales data

Peak sales

Small molecule

Type

Targets：GR, CYP51A1, 30S subunit

Indications (approved)：Bacterial and fungal infection

Regional status

China

Approved

2016-05-31

Japan

Factories producing this API13

Factories registered as producing this API in our sourcing network (RFQ records + product master), sorted by RFQ activity; the snapshot carries no cost or customer data.

13 producing factories on file — sign in to view the named list (factory details are not shown to guests).

Synthetic routes & intermediates5 routes

Originator routes × 0Optimised (non-patent) × 5Process routes × 0

Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.

OptimisedRoute 1Steps 6 · Total yield 80g(Betamethasone-005)

Betamethasone-001560-62-3Betamethasone-00275-86-5Betamethasone-003116256-35-0Betamethasone-004116256-45-2Betamethasone-00563561-93-3Betamethasone-006173350-25-9Betamethasone-007—Betamethasone-008676-58-4Betamethasone-009—API · Betamethasone/Clotrimazole/Gentamicin Sulfate

Code	CAS No.	Intermediate
Betamethasone-001	560-62-3	9-Hydroxyandrost-4-ene-3,17-dione
Betamethasone-002	75-86-5	2-Hydroxy-2-methylpropanenitrile
Betamethasone-003	116256-35-0	(17alpha)-9,17-Dihydroxy-3-oxoandrost-4-ene-17-carbonitrile
Betamethasone-004	116256-45-2	(8S,9R,10S,13S,14S,17R)-9,17-Dihydroxy-10,13-dimethyl-1,2,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydrospiro[cyclopenta[a]phenanthrene-3,2'-[1,3]dioxolane]-17-carbonitrile
Betamethasone-005	63561-93-3	(16beta)-17-Hydroxy-16-methylpregna-4,9(11)-diene-3,20-dione
Betamethasone-006	173350-25-9	(8S,10S,13S,14S)-10,13-Dimethyl-1,2,4,7,8,10,12,13,14,15-decahydrospiro[cyclopenta[a]phenanthrene-3,2'-[1,3]dioxolane]-17-carbonitrile
Betamethasone-007	-	(4'aS,6'aS,6'bR,7'aR,8'aS,8'bS)-4'a,6'a-Dimethyl-3',4',4'a,6',6'a,7'a,8',8'a,8'b,9'-decahydrospiro[1,3-dioxolane-2,2'-naphtho[2',1':4,5]indeno[1,2-b]oxirene]-6'b(1'H)-carbonitrile
Betamethasone-008	676-58-4	Methylmagnesium chloride
Betamethasone-009	-	1-[(8S,10S,13S,14S,16S,17R)-17-Hydroxy-10,13,16-trimethyl-1,2,6,7,8,10,12,13,14,15,16,17-dodecahydrospiro[cyclopenta[a]phenanthrene-3,2'-[1,3]dioxolan]-17-yl]ethan-1-one

OptimisedRoute 1Steps 3 · Total yield /

(I)70353-1-a95-49-8(II)70353-1-a2136-89-2(III)70353-1-a71-43-2(IV)70353-1-a42074-68-0(IX)70353-1-a100-58-3(V)70353-1-a288-32-4(VI)70353-1-a5162-03-8(VII)70353-1-a3509-85-1(VIII)70353-1-a66774-02-5(X)70353-1-a42879-93-6API · Betamethasone/Clotrimazole/Gentamicin Sulfate

Code	CAS No.	Intermediate
(I)70353-1-a	95-49-8	1-Chloranyl-2-methylbenzene
(II)70353-1-a	2136-89-2	1-Chloro-2-(trichloromethyl)benzene
(III)70353-1-a	71-43-2	Benzene
(IV)70353-1-a	42074-68-0	(2-Chlorophenyl) diphenyl chloromethane
(IX)70353-1-a	100-58-3	Bromo(phenyl)magnesium
(V)70353-1-a	288-32-4	1,3-Diaza-2,4-cyclopentadiene
(VI)70353-1-a	5162-03-8	(2-Chlorophenyl)(phenyl)methanone
(VII)70353-1-a	3509-85-1	(2-Chlorophenyl)phenyldichloromethane
(VIII)70353-1-a	66774-02-5	(2-Chlorophenyl)-diphenylmethanol
(X)70353-1-a	42879-93-6	Silver imidazolate

OptimisedRoute 2Steps 6 · Total yield /

(I)70353-2-a89479-33-4(II)70353-2-a40681-65-0(III)70353-2-a68234-52-6(IV)70353-2-a71-43-2(V)70353-2-a68234-53-7(VI)70353-2-a108-86-1(VII)70353-2-a68234-54-8(VIII)70353-2-a68234-55-9(IX)70353-2-a288-32-4(X)70353-2-a53682-83-0API · Betamethasone/Clotrimazole/Gentamicin Sulfate

Code	CAS No.	Intermediate
(I)70353-2-a	89479-33-4	(2-Chlorophenyl)(iodo)magnesium
(II)70353-2-a	40681-65-0	(14C)-2-Chlorobenzoic acid
(III)70353-2-a	68234-52-6	(14C)-2-Chlorobenzoyl chloride
(IV)70353-2-a	71-43-2	Benzene
(V)70353-2-a	68234-53-7	(14C)-2-Chlorobenzophenone
(VI)70353-2-a	108-86-1	Bromanylbenzene
(VII)70353-2-a	68234-54-8	(14C)-(2-Chlorophenyl)diphenylmethanol
(VIII)70353-2-a	68234-55-9	(14C)-1-(2-Chlorophenyl)-1,1-diphenylmethyl chloride
(IX)70353-2-a	288-32-4	1,3-Diaza-2,4-cyclopentadiene
(X)70353-2-a	53682-83-0	(14C)-1-[1-(2-Chlorophenyl)-1,1-diphenylmethyl]-1H-imidazole

OptimisedRoute 3Steps 1 · Total yield /

(I)70353-3-a17849-38-6(II)70353-3-a873-32-5API · Betamethasone/Clotrimazole/Gentamicin Sulfate

Code	CAS No.	Intermediate
(I)70353-3-a	17849-38-6	1-(2-Chlorophenyl)methanol
(II)70353-3-a	873-32-5	1-Chloro-2-cyanobenzene

OptimisedRoute 4Steps 1 · Total yield /

(I)70353-4-a42074-68-0(II)70353-4-a288-32-4API · Betamethasone/Clotrimazole/Gentamicin Sulfate

Code	CAS No.	Intermediate
(I)70353-4-a	42074-68-0	(2-Chlorophenyl) diphenyl chloromethane
(II)70353-4-a	288-32-4	1,3-Diaza-2,4-cyclopentadiene

Frequently asked questions

What are the approved indications of Betamethasone/Clotrimazole/Gentamicin Sulfate?

Approved indications include: Bacterial and fungal infection.

When does the Betamethasone/Clotrimazole/Gentamicin Sulfate patent expire?

No public expiry year is available for Betamethasone/Clotrimazole/Gentamicin Sulfate yet; this page updates once verified.

How many synthesis routes are recorded for Betamethasone/Clotrimazole/Gentamicin Sulfate?

5 synthesis routes are recorded; the shortest is 1 steps with / total yield. Intermediates in each route carry codes and CAS numbers.

Where can I buy Betamethasone/Clotrimazole/Gentamicin Sulfate intermediates?

All intermediates in Betamethasone/Clotrimazole/Gentamicin Sulfate routes have CAS profiles — you can submit an RFQ per CAS and it enters the Unibest matching pool.

How do I get a quote for Betamethasone/Clotrimazole/Gentamicin Sulfate intermediates?

Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.

Source: cross-verified data (structured fields only) · 2026-09-29