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Deuremidevir hydrobromide
Tier C — Watch / tradeDeuremidevir hydrobromide
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Originator
2021
First approval
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Expiry (public)
No sales data
Peak sales
Small molecule
Type
Targets：RdRp, Viral proteins
Brand：Mindevir, MINDEWEI
Indications (approved)：COVID-19
Regional status
US
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EU
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China
Approved
2023-01-28
Japan
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Factories producing this API1
Factories registered as producing this API in our sourcing network (RFQ records + product master), sorted by RFQ activity; the snapshot carries no cost or customer data.
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Sign in to view factories →Synthetic routes & intermediates3 routes
Originator routes × 0Optimised (non-patent) × 3Process routes × 0
Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.
OptimisedRoute 1Steps 7 · Total yield /
(I)1140100-1-a1355357-49-1(II)1140100-1-a—(III)1140100-1-a—(IV)1140100-1-a—(V)1140100-1-a—(VIa)1140100-1-a79-30-1(VIb)1140100-1-a97-72-3(VII)1140100-1-a—(VIII)1140100-1-a—API · Deuremidevir hydrobromide
| Code | CAS No. | Intermediate |
|---|---|---|
| (I)1140100-1-a | 1355357-49-1 | (2R,3R,4R,5R)-2-(4-Aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-bis(benzyloxy)-5-((benzyloxy)methyl)tetrahydrofuran-2-carbonitrile |
| (II)1140100-1-a | - | (2R,3R,4R,5R)-2-(4-Amino-5-iodopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-bis(benzyloxy)-5-[(benzyloxy)methyl]oxolane-2-carbonitrile |
| (III)1140100-1-a | - | (2R,3R,4R,5R)-2-[4-Amino-5-deuteropyrrolo[2,1-f][1,2,4]triazin-7-yl]-3,4-bis(benzyloxy)-5-[(benzyloxy)methyl]oxolane-2-carbonitrile |
| (IV)1140100-1-a | - | (2R,3R,4S,5R)-2-(4-Amino-5-deuteriopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-carbonitrile |
| (V)1140100-1-a | - | N'-[7-[(2R,3R,4S,5R)-2-Cyano-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-deuteropyrrolo[2,1-f][1,2,4]triazin-4-yl]-N,N-dimethylmethanimidamide |
| (VIa)1140100-1-a | 79-30-1Available | 2-Methylpropanoyl chloride |
| (VIb)1140100-1-a | 97-72-3Available | 2-Methylpropanoyl 2-methylpropanoate |
| (VII)1140100-1-a | - | (2R,3R,4R,5R)-2-Cyano-2-[4-[(Z)-[(dimethylamino)methylidene]amino]-5-deuteropyrrolo[2,1-f][1,2,4]triazin-7-yl]-5-[[(2-methylpropanoyl)oxy]methyl]oxolane-3,4-diyl bis(2-methylpropanoate) |
| (VIII)1140100-1-a | - | (2R,3R,4R,5R)-2-[4-Amino-5-deuteropyrrolo[2,1-f][1,2,4]triazin-7-yl]-2-cyano-5-[[(2-methylpropanoyl)oxy]methyl]oxolane-3,4-diyl bis(2-methylpropanoate) |
OptimisedRoute 2Steps 4 · Total yield /
(Ia)1140100-2-a—(Ib)1140100-2-a—(Ic)1140100-2-a—(IIa)1140100-2-a—(IIb)1140100-2-a—(IIc)1140100-2-a—(III)1140100-2-a—(IV)1140100-2-a97-72-3(V)1140100-2-a—(VIa)1140100-2-a—(VIb)1140100-2-a—(VIc)1140100-2-a—(VII)1140100-2-a1191237-69-0(VIII)1140100-2-a2647442-13-3API · Deuremidevir hydrobromide
| Code | CAS No. | Intermediate |
|---|---|---|
| (Ia)1140100-2-a | - | (2R,3R,4R,5R)-2-(4-Amino-5-bromopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-bis(benzyloxy)-5-[(benzyloxy)methyl]oxolane-2-carbonitrile |
| (Ib)1140100-2-a | - | (2R,3R,4R,5R)-2-(4-Amino-5-iodopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-bis(benzyloxy)-5-[(benzyloxy)methyl]oxolane-2-carbonitrile |
| (Ic)1140100-2-a | - | (2R,3R,4R,5R)-2-(4-Amino-5-chloropyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-bis(benzyloxy)-5-[(benzyloxy)methyl]oxolane-2-carbonitrile |
| (IIa)1140100-2-a | - | (2R,3R,4S,5R)-2-(4-Amino-5-bromopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-dihydroxy-5-(hydroxymethyl)oxolane-2-carbonitrile |
| (IIb)1140100-2-a | - | (2R,3R,4S,5R)-2-(4-Amino-5-iodopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-dihydroxy-5-(hydroxymethyl)oxolane-2-carbonitrile |
| (IIc)1140100-2-a | - | (2R,3R,4S,5R)-2-(4-Amino-5-chloropyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-dihydroxy-5-(hydroxymethyl)oxolane-2-carbonitrile |
| (III)1140100-2-a | - | (2R,3R,4S,5R)-2-(4-Amino-5-deuteriopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-carbonitrile |
| (IV)1140100-2-a | 97-72-3Available | 2-Methylpropanoyl 2-methylpropanoate |
| (V)1140100-2-a | - | (2R,3R,4R,5R)-2-[4-Amino-5-deuteropyrrolo[2,1-f][1,2,4]triazin-7-yl]-2-cyano-5-[[(2-methylpropanoyl)oxy]methyl]oxolane-3,4-diyl bis(2-methylpropanoate) |
| (VIa)1140100-2-a | - | (2R,3R,4R,5R)-2-(4-Amino-5-bromopyrrolo[2,1-f][1,2,4]triazin-7-yl)-2-cyano-5-[[(2-methylpropanoyl)oxy]methyl]oxolane-3,4-diyl bis(2-methylpropanoate) |
| (VIb)1140100-2-a | - | (2R,3R,4R,5R)-2-(4-Amino-5-iodopyrrolo[2,1-f][1,2,4]triazin-7-yl)-2-cyano-5-[[(2-methylpropanoyl)oxy]methyl]oxolane-3,4-diyl bis(2-methylpropanoate) |
| (VIc)1140100-2-a | - | (2R,3R,4R,5R)-2-(4-Amino-5-chloropyrrolo[2,1-f][1,2,4]triazin-7-yl)-2-cyano-5-[[(2-methylpropanoyl)oxy]methyl]oxolane-3,4-diyl bis(2-methylpropanoate) |
| (VII)1140100-2-a | 1191237-69-0Available | (2{R},3{R},4{S},5{R})-2-(4-Azanylpyrrolo[2,1-f][1,2,4]triazin-7-yl)-5-(hydroxymethyl)-3,4-bis(oxidanyl)oxolane-2-carbonitrile |
| (VIII)1140100-2-a | 2647442-13-3 | ((2R,3R,4R,5R)-5-(4-Aminopyrrolo(2,1-f)(1,2,4)triazin-7-yl)-5-cyano-3,4-bis(2-methylpropanoyloxy)tetrahydrofuran-2-yl)methyl 2-methylpropanoate |
OptimisedRoute 3Steps 3 · Total yield /
(Ia)1140100-3-a—(Ib)1140100-3-a—(Ic)1140100-3-a—(IIa)1140100-3-a97-72-3(IIb)1140100-3-a79-30-1(III)1140100-3-a—(IV)1140100-3-a—API · Deuremidevir hydrobromide
| Code | CAS No. | Intermediate |
|---|---|---|
| (Ia)1140100-3-a | - | (2R,3R,4S,5R)-2-(4-Amino-5-bromopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-dihydroxy-5-(hydroxymethyl)oxolane-2-carbonitrile |
| (Ib)1140100-3-a | - | (2R,3R,4S,5R)-2-(4-Amino-5-deuteriopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-carbonitrile |
| (Ic)1140100-3-a | - | (2R,3R,4S,5R)-2-[4-Amino-5-deuteropyrrolo[2,1-f][1,2,4]triazin-7-yl]-3,4-dihydroxy-5-(hydroxymethyl)oxolane-2-carbonitrile hydrogen chloride |
| (IIa)1140100-3-a | 97-72-3Available | 2-Methylpropanoyl 2-methylpropanoate |
| (IIb)1140100-3-a | 79-30-1Available | 2-Methylpropanoyl chloride |
| (III)1140100-3-a | - | (2R,3R,4R,5R)-2-[5-Bromo-4-(2-methylpropanamido)pyrrolo[2,1-f][1,2,4]triazin-7-yl]-2-cyano-5-[[(2-methylpropanoyl)oxy]methyl]oxolane-3,4-diyl bis(2-methylpropanoate) |
| (IV)1140100-3-a | - | (2R,3R,4R,5R)-2-Cyano-2-[4-(2-methylpropanamido)-5-deuteropyrrolo[2,1-f][1,2,4]triazin-7-yl]-5-[[(2-methylpropanoyl)oxy]methyl]oxolane-3,4-diyl bis(2-methylpropanoate) |
Frequently asked questions
What are the approved indications of Deuremidevir hydrobromide?
Approved indications include: COVID-19.
When does the Deuremidevir hydrobromide patent expire?
No public expiry year is available for Deuremidevir hydrobromide yet; this page updates once verified.
How many synthesis routes are recorded for Deuremidevir hydrobromide?
3 synthesis routes are recorded; the shortest is 3 steps with / total yield. Intermediates in each route carry codes and CAS numbers.
Where can I buy Deuremidevir hydrobromide intermediates?
3 intermediate CAS of Deuremidevir hydrobromide are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.
How do I get a quote for Deuremidevir hydrobromide intermediates?
Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.
Source: cross-verified data (structured fields only) · 2026-09-29