Dolutegravir/Lamivudine/Tenofovir Alafenamide

Tier C — Watch / trade

Cipla Usa Inc

Originator

2019

First approval

Expiry (public)

No sales data

Peak sales

Small molecule

Type

Targets：HIV integrase, RT

Indications (approved)：HIV infection

Regional status

Approved

2019-09-11

China

Japan

Factories producing this API10

Factories registered as producing this API in our sourcing network (RFQ records + product master), sorted by RFQ activity; the snapshot carries no cost or customer data.

10 producing factories on file — sign in to view the named list (factory details are not shown to guests).

Synthetic routes & intermediates5 routes

Originator routes × 1Optimised (non-patent) × 4Process routes × 0

Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.

OriginatorRoute 1Steps 6 · Total yield 165 mg

LAMI-0013376-59-8LAMI-00264904-47-8LAMI-00353608-94-9LAMI-004138760-43-7LAMI-00571-30-7LAMI-006143957-12-4LAMI-00798-91-9LAMI-0082032-35-1LAMI-009163348-46-7API · Dolutegravir/Lamivudine/Tenofovir Alafenamide

Code	CAS No.	Intermediate
LAMI-001	3376-59-8	2,3-dihydroxypropyl benzoate
LAMI-002	64904-47-8	2-oxoethyl benzoate
LAMI-003	53608-94-9	2,2-diethoxyethanethiol
LAMI-004	138760-43-7	(5-ethoxy-1,3-oxathiolan-2-yl)methyl benzoate
LAMI-005	71-30-7 Available	4-aminopyrimidin-2(1H)-one
LAMI-006	143957-12-4	((2R,5S)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-1,3-oxathiolan-2-yl)methyl benzoate
LAMI-007	98-91-9	benzothioic O-acid
LAMI-008	2032-35-1	2-bromo-1,1-diethoxyethane
LAMI-009	163348-46-7	S-(2,2-diethoxyethyl) benzothioate

OptimisedRoute 2Steps 4 · Total yield /

LAMI-00264904-47-8LAMI-006143957-12-4LAMI-01030163-03-2LAMI-011143957-11-3LAMI-012143957-14-6API · Dolutegravir/Lamivudine/Tenofovir Alafenamide

Code	CAS No.	Intermediate
LAMI-002	64904-47-8	2-oxoethyl benzoate
LAMI-006	143957-12-4	((2R,5S)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-1,3-oxathiolan-2-yl)methyl benzoate
LAMI-010	30163-03-2	(S)-2-hydroxy-3-mercaptopropanoic acid
LAMI-011	143957-11-3	(2R,5S)-2-((benzoyloxy)methyl)-1,3-oxathiolane-5-carboxylic acid
LAMI-012	143957-14-6	((2R)-5-acetoxy-1,3-oxathiolan-2-yl)methyl benzoate

OptimisedRoute 3Steps 5 · Total yield /

LAMI-00571-30-7LAMI-01389-78-1LAMI-0141152495-30-1LAMI-01526315-61-7LAMI-01640018-26-6LAMI-017—LAMI-018147126-65-6LAMI-019147027-10-9API · Dolutegravir/Lamivudine/Tenofovir Alafenamide

Code	CAS No.	Intermediate
LAMI-005	71-30-7 Available	4-aminopyrimidin-2(1H)-one
LAMI-013	89-78-1 Available	(1R,2S,5R)-2-isopropyl-5-methylcyclohexan-1-ol
LAMI-014	1152495-30-1	2-oxoacetic acid hydrate
LAMI-015	26315-61-7	(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl 2-oxoacetate
LAMI-016	40018-26-6	1,4-dithiane-2,5-diol
LAMI-017	-	(2R,5S)-(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl 5-hydroxy-1,3-oxathiolane-2-carboxylate
LAMI-018	147126-65-6	(2R,5S)-(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl 5-acetoxy-1,3-oxathiolane-2-carboxylate
LAMI-019	147027-10-9	(2R,5S)-(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl 5-(4-amino-2-oxopyrimidin-1(2H)-yl)-1,3-oxathiolane-2-carboxylate

OptimisedRoute 4Steps 5 · Total yield /

LAMI-01389-78-1LAMI-018147126-65-6LAMI-02068-11-1LAMI-021298-12-4LAMI-022138760-34-6LAMI-023—LAMI-024200396-19-6LAMI-018-a147126-65-6API · Dolutegravir/Lamivudine/Tenofovir Alafenamide

Code	CAS No.	Intermediate
LAMI-013	89-78-1 Available	(1R,2S,5R)-2-isopropyl-5-methylcyclohexan-1-ol
LAMI-018	147126-65-6	(2R,5S)-(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl 5-acetoxy-1,3-oxathiolane-2-carboxylate
LAMI-020	68-11-1	2-mercaptoacetic acid
LAMI-021	298-12-4 Available	2-oxoacetic acid
LAMI-022	138760-34-6	5-oxo-1,3-oxathiolane-2-carboxylic acid
LAMI-023	-	(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl 5-oxo-1,3-oxathiolane-2-carboxylate
LAMI-024	200396-19-6	(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl 5-hydroxy-1,3-oxathiolane-2-carboxylate
LAMI-018-a	147126-65-6	(2S,5R)-(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl 5-acetoxy-1,3-oxathiolane-2-carboxylate

OptimisedRoute 5Steps 3 · Total yield /

LAMI-00264904-47-8LAMI-012143957-14-6LAMI-01640018-26-6LAMI-02518027-23-1LAMI-0261091585-30-6API · Dolutegravir/Lamivudine/Tenofovir Alafenamide

Code	CAS No.	Intermediate
LAMI-002	64904-47-8	2-oxoethyl benzoate
LAMI-012	143957-14-6	((2R)-5-acetoxy-1,3-oxathiolan-2-yl)methyl benzoate
LAMI-016	40018-26-6	1,4-dithiane-2,5-diol
LAMI-025	18027-23-1	N-(trimethylsilyl)-N-(2-((trimethylsilyl)oxy)pyrimidin-4-yl)acetamide
LAMI-026	1091585-30-6	((2R,5S)-5-(4-acetamido-2-oxopyrimidin-1(2H)-yl)-1,3-oxathiolan-2-yl)methyl benzoate

Frequently asked questions

What are the approved indications of Dolutegravir/Lamivudine/Tenofovir Alafenamide?

Approved indications include: HIV infection.

When does the Dolutegravir/Lamivudine/Tenofovir Alafenamide patent expire?

No public expiry year is available for Dolutegravir/Lamivudine/Tenofovir Alafenamide yet; this page updates once verified.

How many synthesis routes are recorded for Dolutegravir/Lamivudine/Tenofovir Alafenamide?

5 synthesis routes are recorded; the shortest is 3 steps with / total yield. Intermediates in each route carry codes and CAS numbers.

Where can I buy Dolutegravir/Lamivudine/Tenofovir Alafenamide intermediates?

3 intermediate CAS of Dolutegravir/Lamivudine/Tenofovir Alafenamide are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.

How do I get a quote for Dolutegravir/Lamivudine/Tenofovir Alafenamide intermediates?

Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.

Source: cross-verified data (structured fields only) · 2026-09-29