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Josamycin Propionate
Tier C — Watch / tradeJosamycin Propionate
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Originator
1995
First approval
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Expiry (public)
No sales data
Peak sales
Small molecule
Type
Targets：50S ribosomal subunit
Indications (approved)：Bacterial infection, Inflammatory disease
Regional status
US
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EU
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China
Approved
1995-01-01
Japan
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Synthetic routes & intermediates3 routes
Originator routes × 0Optimised (non-patent) × 3Process routes × 0
Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.
OptimisedRoute 1Steps 13 · Total yield /
Josamycin-001582-52-5Josamycin-002—Josamycin-003—Josamycin-004—Josamycin-005—Josamycin-006—Josamycin-0072605-67-6Josamycin-008—Josamycin-00976859-44-4Josamycin-010—Josamycin-01176859-46-6Josamycin-012—Josamycin-01376859-47-7Josamycin-014—Josamycin-01576859-48-8API · Josamycin Propionate
| Code | CAS No. | Intermediate |
|---|---|---|
| Josamycin-001 | 582-52-5 | (3aR,5S,6S,6aR)-5-[(4R)-2,2-Dimethyl-1,3-dioxolan-4-yl]-2,2-dimethyltetrahydro-2H-furo[2,3-d][1,3]dioxol-6-ol |
| Josamycin-002 | - | (3aS,5S,6R,6aS)-5-[(4S)-2,2-Dimethyl-1,3-dioxolan-4-yl]-6-methoxy-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxole |
| Josamycin-003 | - | 1,2-O-Isopropylidene-3-O-methyl-alpha-L-glucofuranose |
| Josamycin-004 | - | 6-O-Benzoyl-1,2-O-isopropylidene-3-O-methyl-alpha-L-glucofuranose |
| Josamycin-005 | - | 6-O-Benzoyl-1,2-O-isopropylidene-3-O-methyl-5-O-[(4-methylphenyl)sulfonyl]-alpha-L-glucofuranose |
| Josamycin-006 | - | 5-Deoxy-1,2-O-isopropylidene-3-O-methyl-alpha-L-xylo-hexofuranose |
| Josamycin-007 | 2605-67-6 | (Carbomethoxymethylene)triphenylphosphorane |
| Josamycin-008 | - | Methyl (2E)-2,3,7-trideoxy-5-O-methyl-D-xylo-oct-2-enonate |
| Josamycin-009 | 76859-44-4 | Methyl (2E)-2,3,7-trideoxy-4,6-O-isopropylidene-8-O-(methoxymethyl)-5-O-methyl-D-xylo-oct-2-enonate |
| Josamycin-010 | - | Methyl (4xi)-2,3,7-trideoxy-4,6-O-isopropylidene-8-O-(methoxymethyl)-5-O-methyl-3-[(methylsulfanyl)(methylsulfinyl)methyl]-D-lyxo-octonate |
| Josamycin-011 | 76859-46-6 | (4R,5S)-5-[(1S,2R)-2,4-Dihydroxy-1-methoxybutyl]-4-[(ethylsulfanyl)(methylsulfanyl)methyl]dihydrofuran-2(3H)-one |
| Josamycin-012 | - | 2,3,7-Trideoxy-3-[(ethylsulfanyl)(methylsulfanyl)methyl]-5-O-methyl-D-ido-octofuranose |
| Josamycin-013 | 76859-47-7 | Methyl 2,3,7-trideoxy-3-[(ethylsulfanyl)(methylsulfanyl)methyl]-5-O-methyl-D-ido-octofuranoside |
| Josamycin-014 | - | Methyl 6,8-di-O-benzyl-2,3,7-trideoxy-3-[(ethylsulfanyl)(methylsulfanyl)methyl]-5-O-methyl-D-ido-octofuranoside |
| Josamycin-015 | 76859-48-8 | Methyl 6,8-di-O-benzyl-2,3,7-trideoxy-3-formyl-5-O-methyl-D-ido-octofuranoside |
OptimisedRoute 2Steps 8 · Total yield /
Josamycin-01576859-48-8Josamycin-01626487-92-3Josamycin-0174091-39-8Josamycin-018—Josamycin-019—Josamycin-020—Josamycin-021—Josamycin-022—Josamycin-023—Josamycin-024—Josamycin-025—API · Josamycin Propionate
| Code | CAS No. | Intermediate |
|---|---|---|
| Josamycin-015 | 76859-48-8 | Methyl 6,8-di-O-benzyl-2,3,7-trideoxy-3-formyl-5-O-methyl-D-ido-octofuranoside |
| Josamycin-016 | 26487-92-3 | 3-(Triphenylphosphoranylidene)butan-2-one |
| Josamycin-017 | 4091-39-8 | 1-Acetyl-1-chloroethane |
| Josamycin-018 | - | Methyl 6,8-di-O-benzyl-2,3,7-trideoxy-5-O-methyl-3-[(1Z)-2-methyl-3-oxobut-1-en-1-yl]-D-ido-octofuranoside |
| Josamycin-019 | - | Methyl 2,3,7-trideoxy-5-O-methyl-3-(2-methyl-3-oxobutyl)-D-ido-octofuranoside |
| Josamycin-020 | - | Methyl 2,3,7-trideoxy-5-O-methyl-3-(2-methyl-3-oxobutyl)-D-ido-octofuranosiduronic acid |
| Josamycin-021 | - | Dimethyl 2,3,7-trideoxy-5-O-methyl-3-[(2R)-2-methyl-3-oxobutyl]-D-ido-octofuranosiduronate |
| Josamycin-022 | - | (2E)-5-Hydroxyhex-2-enal |
| Josamycin-023 | - | Dimethyl 2,3,7-trideoxy-3-[(2R,4E,6E,9R)-9-hydroxy-2-methyl-3-oxodeca-4,6-dien-1-yl]-5-O-methyl-D-ido-octofuranosiduronate |
| Josamycin-024 | - | Methyl 2,3,7-trideoxy-3-[(2R,4E,6E,9R)-3,9-dihydroxy-2-methyldeca-4,6-dien-1-yl]-5-O-methyl-D-ido-octofuranosiduronic acid |
| Josamycin-025 | - | Methyl S-phenyl 2,3,7-trideoxy-3-[(2R,4E,6E,9R)-3,9-dihydroxy-2-methyldeca-4,6-dien-1-yl]-5-O-methyl-8-thio-D-ido-octofuranosiduronate |
OptimisedRoute 3Steps 5 · Total yield /
Josamycin-025—Josamycin-02676859-54-6Josamycin-027—Josamycin-028—Josamycin-029—Josamycin-030—API · Josamycin Propionate
| Code | CAS No. | Intermediate |
|---|---|---|
| Josamycin-025 | - | Methyl S-phenyl 2,3,7-trideoxy-3-[(2R,4E,6E,9R)-3,9-dihydroxy-2-methyldeca-4,6-dien-1-yl]-5-O-methyl-8-thio-D-ido-octofuranosiduronate |
| Josamycin-026 | 76859-54-6 | (3aR,5R,7E,9E,12R,16R,17S,17aS)-6,16-Dihydroxy-2,17-dimethoxy-5,12-dimethyl-2,3,3a,4,5,6,11,12,15,16,17,17a-dodecahydro-14H-furo[2,3-f]oxacyclohexadecin-14-one |
| Josamycin-027 | - | (3aR,5R,7E,9E,12R,16R,17S,17aS)-16-Hydroxy-2,17-dimethoxy-5,12-dimethyl-3,3a,11,12,15,16,17,17a-octahydro-4H-furo[2,3-f]oxacyclohexadecine-6,14(2H,5H)-dione |
| Josamycin-028 | - | (3aR,5R,7E,9E,12R,16R,17S,17aS)-2,17-Dimethoxy-5,12-dimethyl-6,14-dioxo-2,3,3a,5,6,11,12,14,15,16,17,17a-dodecahydro-4H-furo[2,3-f]oxacyclohexadecin-16-yl acetate |
| Josamycin-029 | - | (3aR,5R,7E,9E,12R,16R,17S,17aS)-2-Hydroxy-17-methoxy-5,12-dimethyl-6,14-dioxo-2,3,3a,5,6,11,12,14,15,16,17,17a-dodecahydro-4H-furo[2,3-f]oxacyclohexadecin-16-yl acetate |
| Josamycin-030 | - | (4R,5R,6S,7R,9R,11E,13E,16R)-7-(1,3-Dioxolan-2-ylmethyl)-6-hydroxy-5-methoxy-9,16-dimethyl-2,10-dioxooxacyclohexadeca-11,13-dien-4-yl acetate |
Frequently asked questions
What are the approved indications of Josamycin Propionate?
Approved indications include: Bacterial infection, Inflammatory disease.
When does the Josamycin Propionate patent expire?
No public expiry year is available for Josamycin Propionate yet; this page updates once verified.
How many synthesis routes are recorded for Josamycin Propionate?
3 synthesis routes are recorded; the shortest is 5 steps with / total yield. Intermediates in each route carry codes and CAS numbers.
Where can I buy Josamycin Propionate intermediates?
All intermediates in Josamycin Propionate routes have CAS profiles — you can submit an RFQ per CAS and it enters the Unibest matching pool.
How do I get a quote for Josamycin Propionate intermediates?
Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.
Source: cross-verified data (structured fields only) · 2026-10-04