Linezolid
Tier B — Position earlyLinezolid
Targets：50S ribosomal subunit
Brand：Zolodine, Zyvoxam, Zyvoxid, Zyvoxa, Zyvox
Indications (approved)：非复杂性皮肤和皮肤结构感染, Pneumonia, Complicated skin and skin structure infection, Bacteraemia, Bacterial infection, Healthcare-associated pneumonia, Infectious disease, Staphylococcal infection
Regional status
Synthetic routes & intermediates5 routes
Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.
| Code | CAS No. | Intermediate |
|---|---|---|
| LINE-001 | 369-34-6 | 1,2-difluoro-4-nitrobenzene |
| LINE-002 | 110-91-8Available | morpholine |
| LINE-003 | 2689-39-6 | 4-(2-fluoro-4-nitrophenyl)morpholine |
| LINE-004 | 93246-53-8 | 3-fluoro-4-morpholinoaniline |
| LINE-005 | 168828-81-7 | benzyl (3-fluoro-4-morpholinophenyl)carbamatebenzyl (3-fluoro-4-morpholinophenyl)carbamate |
| LINE-006 | 60456-26-0Available | (R)-oxiran-2-ylmethyl butyrate |
| LINE-007 | 168828-82-8 | (R)-3-(3-fluoro-4-morpholinophenyl)-5-(hydroxymethyl)oxazolidin-2-one |
| LINE-008 | 174649-09-3 | (R)-(3-(3-fluoro-4-morpholinophenyl)-2-oxooxazolidin-5-yl)methyl methanesulfonate |
| LINE-009 | 168828-84-0 | (R)-5-(azidomethyl)-3-(3-fluoro-4-morpholinophenyl)oxazolidin-2-one |
| Code | CAS No. | Intermediate |
|---|---|---|
| LINE-004 | 93246-53-8 | 3-fluoro-4-morpholinoaniline |
| LINE-010 | 5736-03-8 | N-((2,2-dimethyl-1,3-dioxolan-4-yl)methyl)-3-fluoro-4-morpholinoaniline |
| LINE-011 | 5736-03-8 | N-((2,2-dimethyl-1,3-dioxolan-4-yl)methyl)-3-fluoro-4-morpholinoaniline |
| LINE-012 | 541-41-3 | ethyl carbonochloridate |
| LINE-013 | 1088110-89-7 | ethyl ((2,2-dimethyl-1,3-dioxolan-4-yl)methyl)(3-fluoro-4-morpholinophenyl)carbamate |
| LINE-014 | 1088110-90-0 | ethyl (2,3-dihydroxypropyl)(3-fluoro-4-morpholinophenyl)carbamate |
| LINE-015 | 1088110-91-1 | ethyl (3-fluoro-4-morpholinophenyl)(2-oxoethyl)carbamate |
| LINE-016 | 1088110-92-2 | (R)-N-((R)-1-hydroxy-4-methyl-1,1-diphenylpentan-2-yl)pyrrolidine-2-carboxamide |
| LINE-017 | 1088110-93-3 | ethyl (S)-(3-fluoro-4-morpholinophenyl)(2-hydroxy-4-oxopentyl)carbamate |
| LINE-018 | 1088110-97-7 | ethyl (S,E)-(3-fluoro-4-morpholinophenyl)(2-hydroxy-4-(hydroxyimino)pentyl)carbamate |
| LINE-019 | 1088111-01-6 | (S,E)-3-(3-fluoro-4-morpholinophenyl)-5-(2-(hydroxyimino)propyl)oxazolidin-2-one |
| Code | CAS No. | Intermediate |
|---|---|---|
| LINE-001 | 369-34-6 | 1,2-difluoro-4-nitrobenzene |
| LINE-002 | 110-91-8Available | morpholine |
| LINE-003 | 2689-39-6 | 4-(2-fluoro-4-nitrophenyl)morpholine |
| LINE-004 | 93246-53-8 | 3-fluoro-4-morpholinoaniline |
| LINE-009 | 168828-84-0 | (R)-5-(azidomethyl)-3-(3-fluoro-4-morpholinophenyl)oxazolidin-2-one |
| LINE-020 | 224323-51-7 | 4-(2-fluoro-4-isocyanatophenyl)morpholine |
| LINE-021 | 51594-55-9 | (R)-2-(chloromethyl)oxirane |
| LINE-022 | 496031-57-3 | (R)-5-(chloromethyl)-3-(3-fluoro-4-morpholinophenyl)oxazolidin-2-one |
| Code | CAS No. | Intermediate |
|---|---|---|
| LINE-004 | 93246-53-8 | 3-fluoro-4-morpholinoaniline |
| LINE-009 | 168828-84-0 | (R)-5-(azidomethyl)-3-(3-fluoro-4-morpholinophenyl)oxazolidin-2-one |
| LINE-023 | 67843-74-7Available | (S)-2-(chloromethyl)oxirane |
| LINE-024 | 681225-50-3Available | (S)-1-azido-3-chloropropan-2-ol |
| LINE-025 | 681225-56-9 | (R)-2-(azidomethyl)oxirane |
| LINE-026 | 1571118-50-7 | (R)-1-azido-3-((3-fluoro-4-morpholinophenyl)amino)propan-2-ol |
| LINE-027 | 168828-90-8 | (S)-5-(aminomethyl)-3-(3-fluoro-4-morpholinophenyl)oxazolidin-2-one |
| Code | CAS No. | Intermediate |
|---|---|---|
| LINE-028 | 513068-89-8 | 4-(4-bromo-2-fluorophenyl)morpholine |
| LINE-029 | 7517-99-9 | 5-(hydroxymethyl)oxazolidin-2-one |
| LINE-030 | 513068-96-7 | 3-(3-fluoro-4-morpholinophenyl)-5-(hydroxymethyl)oxazolidin-2-one |
| LINE-031 | 858344-36-2 | (3-(3-fluoro-4-morpholinophenyl)-2-oxooxazolidin-5-yl)methyl methanesulfonate |
| LINE-032 | 1385053-41-7 | 5-(azidomethyl)-3-(3-fluoro-4-morpholinophenyl)oxazolidin-2-one |
| LINE-033 | 1352030-06-8 | 5-(aminomethyl)-3-(3-fluoro-4-morpholinophenyl)oxazolidin-2-one |
Frequently asked questions
What are the approved indications of Linezolid?
Approved indications include: 非复杂性皮肤和皮肤结构感染, Pneumonia, Complicated skin and skin structure infection, Bacteraemia, Bacterial infection, Healthcare-associated pneumonia, Infectious disease, Staphylococcal infection.
When does the Linezolid patent expire?
No public expiry year is available for Linezolid yet; this page updates once verified.
How many synthesis routes are recorded for Linezolid?
5 synthesis routes are recorded; the shortest is 5 steps with / total yield. Intermediates in each route carry codes and CAS numbers.
Where can I buy Linezolid intermediates?
4 intermediate CAS of Linezolid are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.
How do I get a quote for Linezolid intermediates?
Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.
Source: cross-verified data (structured fields only) · 2026-09-29