Chlorthalidone

Tier C — Watch / trade

Chlorthalidone

Sanofi

Originator

1959

First approval

Expiry (public)

No sales data

Peak sales

Small molecule

Type

Targets：Thiazide-sensitive sodium-chloride cotransporter

Brand：Hygroton, HemiClor, Thalitone

Indications (approved)：Hypertension, Oedema, Diabetes insipidus, Kidney stones

Regional status

Approved

1960-04-07

Approved

1959-01-01

China

Approved

1985-01-01

Japan

Synthetic routes & intermediates2 routes

Originator routes × 0Optimised (non-patent) × 2Process routes × 0

Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.

OptimisedRoute 1Steps 4 · Total yield /

Chlorthalidone-001—Chlorthalidone-002—Chlorthalidone-003—Chlorthalidone-004—API · Chlorthalidone

Code	CAS No.	Intermediate
Chlorthalidone-001	-	2-[3-Amino-4-chlorobenzoyl]benzoic acid
Chlorthalidone-002	-	5-[2-Carboxybenzoyl]-2-chlorobenzenediazonium chloride
Chlorthalidone-003	-	2-[4-Chloro-3-(chlorosulfonyl)benzoyl]benzoic acid
Chlorthalidone-004	-	2-Chloro-5-(1-chloro-3-oxo-2-benzofuran-1-yl)benzenesulfonyl chloride

OptimisedRoute 2Steps 6 · Total yield 198g(Chlorthalidone (Free))

Chlorthalidone-005—Chlorthalidone-006—Chlorthalidone-007—Chlorthalidone-008—Chlorthalidone-0092224-83-1Chlorthalidone-0102224-77-3Chlorthalidone-011—Chlorthalidone-01282875-50-1Chlorthalidone-01382875-49-8API · Chlorthalidone

Code	CAS No.	Intermediate
Chlorthalidone-005	-	1-Chlorobenzene
Chlorthalidone-006	-	1,2-Benzenedicarboxylic acid anhydride
Chlorthalidone-007	-	2-(4-Chlorobenzoyl)benzoic acid
Chlorthalidone-008	-	Sodium 2-(4-chlorobenzoyl)benzoate
Chlorthalidone-009	2224-83-1	4-(4-Chlorophenyl)-1H-2,3-benzoxazin-1-one
Chlorthalidone-010	2224-77-3	3-(4-Chlorophenyl)-2,3-dihydro-1H-isoindol-1-one
Chlorthalidone-011	-	Chloridosulfuric acid
Chlorthalidone-012	82875-50-1	2-Chloro-5-(3-oxo-2,3-dihydro-1H-isoindol-1-yl)benzene-1-sulfonyl chloride
Chlorthalidone-013	82875-49-8	2-Chloro-5-(3-oxo-2,3-dihydro-1H-isoindol-1-yl)benzene-1-sulfonamide

Frequently asked questions

What are the approved indications of Chlorthalidone?

Approved indications include: Hypertension, Oedema, Diabetes insipidus, Kidney stones.

When does the Chlorthalidone patent expire?

No public expiry year is available for Chlorthalidone yet; this page updates once verified.

How many synthesis routes are recorded for Chlorthalidone?

2 synthesis routes are recorded; the shortest is 4 steps with / total yield. Intermediates in each route carry codes and CAS numbers.

Where can I buy Chlorthalidone intermediates?

All intermediates in Chlorthalidone routes have CAS profiles — you can submit an RFQ per CAS and it enters the Unibest matching pool.

How do I get a quote for Chlorthalidone intermediates?

Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.

Source: cross-verified data (structured fields only) · 2026-09-29