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Ticagrelor
Tier B — Position earlyTicagrelor · all drugs expiring in 2029 →
AstraZeneca
Originator
2010
First approval
2029
Expiry (public)
$1.59B ▲
Peak sales
Small molecule
Type
Targets：P2RY12
Brand：Brilinta, Possia, Brilinta/Brilique, Brilique
Indications (approved)：Stroke, Acute coronary syndrome, Myocardial infarction, Peripheral vascular disease
Regional status
US
Approved
2011-07-20
EU
Approved
2010-12-03
China
Approved
2012-11-22
Japan
Approved
2016-09-28
Factories producing this API1
Factories registered as producing this API in our sourcing network (RFQ records + product master), sorted by RFQ activity; the snapshot carries no cost or customer data.
1 producing factories on file — sign in to view the named list (factory details are not shown to guests).
Sign in to view factories →Synthetic routes & intermediates5 routes
Originator routes × 1Optimised (non-patent) × 4Process routes × 0
Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.
OriginatorRoute 1Steps 9 · Total yield /
| Code | CAS No. | Intermediate |
|---|---|---|
| TICA-001 | 145783-14-8Available | 4,6-dichloro-5-nitro-2-(propylthio)pyrimidine |
| TICA-002 | 155899-66-4Available | (3aR,4S,6R,6aS)-6-amino-2,2-dimethyltetrahydro-4H-cyclopenta[d][1,3]dioxol-4-ol |
| TICA-003 | 220241-59-8Available | (3aR,4S,6R,6aS)-6-((6-chloro-5-nitro-2-(propylthio)pyrimidin-4-yl)amino)-2,2-dimethyltetrahydro-4H-cyclopenta[d][1,3]dioxol-4-ol |
| TICA-004 | 220241-60-1Available | (3aR,4S,6R,6aS)-6-((5-amino-6-chloro-2-(propylthio)pyrimidin-4-yl)amino)-2,2-dimethyltetrahydro-4H-cyclopenta[d][1,3]dioxol-4-ol |
| TICA-005 | 220241-61-2Available | (3aR,4S,6R,6aS)-6-(7-chloro-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2,2-dimethyltetrahydro-4H-cyclopenta[d][1,3]dioxol-4-ol |
| TICA-006 | 274693-22-0Available | (3aR,4S,6R,6aS)-6-(7-amino-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2,2-dimethyltetrahydro-4H-cyclopenta[d][1,3]dioxol-4-ol |
| TICA-007 | 88016-31-3Available | methyl 2-(((trifluoromethyl)sulfonyl)oxy)acetate |
| TICA-008 | 274693-23-1Available | methyl 2-(((3aR,4S,6R,6aS)-6-(7-amino-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2,2-dimethyltetrahydro-4H-cyclopenta[d][1,3]dioxol-4-yl)oxy)acetate |
| TICA-009 | 274693-24-2Available | methyl 2-(((3aR,4S,6R,6aS)-6-(7-bromo-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2,2-dimethyltetrahydro-4H-cyclopenta[d][1,3]dioxol-4-yl)oxy)acetate |
| TICA-010 | 220352-38-5Available | (1R,2S)-2-(3,4-difluorophenyl)cyclopropan-1-amine |
| TICA-011 | 274693-25-3Available | methyl 2-(((3aR,4S,6R,6aS)-6-(7-(((1R,2S)-2-(3,4-difluorophenyl)cyclopropyl)amino)-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2,2-dimethyltetrahydro-4H-cyclopenta[d][1,3]dioxol-4-yl)oxy)acetate |
| TICA-012 | 30472-97-0Available | potassium sodium (2R,3R)-2,3-dihydroxysuccinate |
| TICA-013 | 274693-26-4Available | 2-(((3aR,4S,6R,6aS)-6-(7-(((1R,2S)-2-(3,4-difluorophenyl)cyclopropyl)amino)-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2,2-dimethyltetrahydro-4H-cyclopenta[d][1,3]dioxol-4-yl)oxy)ethan-1-ol |
| TICA-014 | 60410-16-4Available | (1R,4S)-4-hydroxycyclopent-2-en-1-yl acetate |
| TICA-015 | 51779-32-9Available | - |
| TICA-016 | 220241-57-6Available | - |
| TICA-017 | 7529-22-8Available | 4-methylmorpholine 4-oxide |
| TICA-018 | 220241-58-7Available | - |
| TICA-019 | 77-76-9Available | 2,2-dimethoxypropane |
OptimisedRoute 2Steps 9 · Total yield 19 mg
| Code | CAS No. | Intermediate |
|---|---|---|
| TICA-010 | 220352-38-5Available | (1R,2S)-2-(3,4-difluorophenyl)cyclopropan-1-amine |
| TICA-013 | 274693-26-4Available | 2-(((3aR,4S,6R,6aS)-6-(7-(((1R,2S)-2-(3,4-difluorophenyl)cyclopropyl)amino)-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2,2-dimethyltetrahydro-4H-cyclopenta[d][1,3]dioxol-4-yl)oxy)ethan-1-ol |
| TICA-020 | 2171459-69-9Available | 6-hydroxy-2-thioxo-2,3-dihydropyrimidin-4(1H)-one |
| TICA-021 | 107-08-4Available | 1-iodopropane |
| TICA-022 | 145783-12-6Available | 2-(propylthio)pyrimidine-4,6-diol |
| TICA-023 | 106-49-0Available | p-toluidine |
| TICA-024 | 376608-72-9Available | (E)-2-(propylthio)-5-(p-tolyldiazenyl)pyrimidine-4,6-diol |
| TICA-025 | 376608-73-0Available | (E)-4,6-dichloro-2-(propylthio)-5-(p-tolyldiazenyl)pyrimidine |
| TICA-026 | 1415806-23-3Available | 4,6-dichloro-2-(propylthio)-5-(2-(p-tolyl)hydrazinyl)pyrimidine |
| TICA-027 | 145783-15-9Available | 4,6-dichloro-2-(propylthio)pyrimidin-5-amine |
| TICA-028 | 274693-55-9Available | 2-(((3aR,4S,6R,6aS)-6-amino-2,2-dimethyltetrahydro-4H-cyclopenta[d][1,3]dioxol-4-yl)oxy)ethan-1-ol |
| TICA-029 | 376608-74-1Available | 2-(((3aR,4S,6R,6aS)-6-((5-amino-6-chloro-2-(propylthio)pyrimidin-4-yl)amino)-2,2-dimethyltetrahydro-4H-cyclopenta[d][1,3]dioxol-4-yl)oxy)ethan-1-ol |
| TICA-030 | 376608-75-2Available | 2-(((3aR,4S,6R,6aS)-6-(7-chloro-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2,2-dimethyltetrahydro-4H-cyclopenta[d][1,3]dioxol-4-yl)oxy)ethan-1-ol |
OptimisedRoute 3Steps 7 · Total yield /
| Code | CAS No. | Intermediate |
|---|---|---|
| TICA-010 | 220352-38-5Available | (1R,2S)-2-(3,4-difluorophenyl)cyclopropan-1-amine |
| TICA-031 | 34036-07-2Available | 3,4-difluorobenzaldehyde |
| TICA-032 | 141-82-2Available | malonic acid |
| TICA-033 | 112897-97-9Available | (E)-3-(3,4-difluorophenyl)acrylic acid |
| TICA-034 | 376608-66-1Available | (E)-3-(3,4-difluorophenyl)acryloyl chloride |
| TICA-035 | 89-78-1Available | (1R,2S,5R)-2-isopropyl-5-methylcyclohexan-1-ol |
| TICA-036 | 376608-67-2Available | (1R,2S,5R)-2-isopropyl-5-methylcyclohexyl (E)-3-(3,4-difluorophenyl)acrylate |
| TICA-037 | 376608-68-3Available | (1R,2S,5R)-2-isopropyl-5-methylcyclohexyl (1R,2R)-2-(3,4-difluorophenyl)cyclopropane-1-carboxylate |
| TICA-038 | 220352-36-3Available | (1R,2R)-2-(3,4-difluorophenyl)cyclopropane-1-carboxylic acid |
| TICA-039 | 378236-67-0Available | (1R,2R)-2-(3,4-difluorophenyl)cyclopropane-1-carbonyl azide |
OptimisedRoute 4Steps 5 · Total yield 192 mg
| Code | CAS No. | Intermediate |
|---|---|---|
| TICA-027 | 145783-15-9Available | 4,6-dichloro-2-(propylthio)pyrimidin-5-amine |
| TICA-040 | 1068-90-2Available | diethyl 2-acetamidomalonate |
| TICA-041 | 62-56-6Available | thiourea |
| TICA-042 | 1549834-16-3Available | sodium 5-acetamido-4,6-dihydroxypyrimidine-2-thiolate |
| TICA-043 | 133030-24-7Available | N-(4,6-dihydroxy-2-mercaptopyrimidin-5-yl)acetamide |
| TICA-044 | 106-94-5Available | 1-bromopropane |
| TICA-045 | 1549834-56-1Available | N-(4,6-dihydroxy-2-(propylthio)pyrimidin-5-yl)acetamide |
| TICA-046 | 1549834-66-3Available | 5-amino-2-(propylthio)pyrimidine-4,6-diol hydrochloride |
OptimisedRoute 5Steps 9 · Total yield 0.48 g
| Code | CAS No. | Intermediate |
|---|---|---|
| TICA-001 | 145783-14-8Available | 4,6-dichloro-5-nitro-2-(propylthio)pyrimidine |
| TICA-010 | 220352-38-5Available | (1R,2S)-2-(3,4-difluorophenyl)cyclopropan-1-amine |
| TICA-047 | 866551-95-3Available | ethyl 2-(((3aR,4S,6R,6aS)-6-(((benzyloxy)carbonyl)amino)-2,2-dimethyltetrahydro-4H-cyclopenta[d][1,3]dioxol-4-yl)oxy)acetate |
| TICA-048 | 1612796-22-1Available | ethyl 2-(((1S,2S,3S,4R)-4-(((benzyloxy)carbonyl)amino)-2,3-dihydroxycyclopentyl)oxy)acetate |
| TICA-049 | 1612796-23-2Available | ethyl 2-(((3aR,4S,6R,6aS)-6-(((benzyloxy)carbonyl)amino)-2-oxotetrahydro-4H-cyclopenta[d][1,3]dioxol-4-yl)oxy)acetate |
| TICA-050 | 1612796-24-3Available | benzyl ((3aS,4R,6S,6aR)-6-(2-hydroxyethoxy)-2-oxotetrahydro-4H-cyclopenta[d][1,3]dioxol-4-yl)carbamate |
| TICA-051 | 1612796-25-4Available | (3aS,4R,6S,6aR)-4-amino-6-(2-hydroxyethoxy)tetrahydro-4H-cyclopenta[d][1,3]dioxol-2-one |
| TICA-052 | 1612796-35-6Available | (3aS,4R,6S,6aR)-4-((6-chloro-5-nitro-2-(propylthio)pyrimidin-4-yl)amino)-6-(2-hydroxyethoxy)tetrahydro-4H-cyclopenta[d][1,3]dioxol-2-one |
| TICA-053 | 1482484-91-2Available | (3aS,4R,6S,6aR)-4-((5-amino-6-chloro-2-(propylthio)pyrimidin-4-yl)amino)-6-(2-hydroxyethoxy)tetrahydro-4H-cyclopenta[d][1,3]dioxol-2-one |
| TICA-054 | 1612796-36-7Available | (3aS,4R,6S,6aR)-4-(7-chloro-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-6-(2-hydroxyethoxy)tetrahydro-4H-cyclopenta[d][1,3]dioxol-2-one |
| TICA-055 | 1612796-37-8Available | (3aS,4R,6S,6aR)-4-(7-(((1R,2S)-2-(3,4-difluorophenyl)cyclopropyl)amino)-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-6-(2-hydroxyethoxy)tetrahydro-4H-cyclopenta[d][1,3]dioxol-2-one |
Frequently asked questions
What are the approved indications of Ticagrelor?
Approved indications include: Stroke, Acute coronary syndrome, Myocardial infarction, Peripheral vascular disease.
When does the Ticagrelor patent expire?
Based on public sources, the Ticagrelor patent expires in 2029.
How many synthesis routes are recorded for Ticagrelor?
5 synthesis routes are recorded; the shortest is 5 steps with 192 mg total yield. Intermediates in each route carry codes and CAS numbers.
Where can I buy Ticagrelor intermediates?
55 intermediate CAS of Ticagrelor are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.
How do I get a quote for Ticagrelor intermediates?
Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.
Source: cross-verified data (structured fields only) · 2026-09-29