Estradiol Valerate/Norethindrone Acetate

Tier C — Watch / trade

Dr. Kade Pharmazeutische Fabrik GmbH

Originator

2006

First approval

Expiry (public)

No sales data

Peak sales

Small molecule

Type

Targets：ERs, PR

Brand：Cliovelle, Cliovellan

Indications (approved)：Oestrogen deficiency syndrome, Postmenopausal osteoporosis

Regional status

Approved

2006-02-03

China

Japan

Factories producing this API9

Factories registered as producing this API in our sourcing network (RFQ records + product master), sorted by RFQ activity; the snapshot carries no cost or customer data.

9 producing factories on file — sign in to view the named list (factory details are not shown to guests).

Synthetic routes & intermediates1 routes

Originator routes × 0Optimised (non-patent) × 1Process routes × 0

Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.

OptimisedRoute 1Steps 3 · Total yield 90g(Estradiol Valerate (Free))

Estradiol Valerate-001—Estradiol Valerate-002—Estradiol Valerate-00363042-28-4Estradiol Valerate-004—API · Estradiol Valerate/Norethindrone Acetate

Code	CAS No.	Intermediate
Estradiol Valerate-001	-	(17beta)-Estra-1,3,5(10)-triene-3,17-diol
Estradiol Valerate-002	-	Pentanoic anhydride
Estradiol Valerate-003	63042-28-4	(17beta)-Estra-1,3,5(10)-triene-3,17-diyl dipentanoate
Estradiol Valerate-004	-	Butanecarboxylic acid

Frequently asked questions

What are the approved indications of Estradiol Valerate/Norethindrone Acetate?

Approved indications include: Oestrogen deficiency syndrome, Postmenopausal osteoporosis.

When does the Estradiol Valerate/Norethindrone Acetate patent expire?

No public expiry year is available for Estradiol Valerate/Norethindrone Acetate yet; this page updates once verified.

How many synthesis routes are recorded for Estradiol Valerate/Norethindrone Acetate?

1 synthesis routes are recorded; the shortest is 3 steps with 90g(Estradiol Valerate (Free)) total yield. Intermediates in each route carry codes and CAS numbers.

Where can I buy Estradiol Valerate/Norethindrone Acetate intermediates?

All intermediates in Estradiol Valerate/Norethindrone Acetate routes have CAS profiles — you can submit an RFQ per CAS and it enters the Unibest matching pool.

How do I get a quote for Estradiol Valerate/Norethindrone Acetate intermediates?

Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.

Source: cross-verified data (structured fields only) · 2026-09-29