Upadacitinib
Tier B — Position earlyUpadacitinib · all drugs expiring in 2033 →
Targets：JAK1
Brand：RINVOQ LQ, Rinvoq Lq, Rinvoq
Indications (approved)：Alopecia areata, Giant cell arteritis, Ankylosing spondylitis, Spondyloarthritis, Crohn's disease, Non-radiographic axial spondyloarthritis, Ulcerative colitis, Psoriatic arthritis
Regional status
Factories producing this API1
Factories registered as producing this API in our sourcing network (RFQ records + product master), sorted by RFQ activity; the snapshot carries no cost or customer data.
1 producing factories on file — sign in to view the named list (factory details are not shown to guests).
Sign in to view factories →Synthetic routes & intermediates1 routes
Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.
| Code | CAS No. | Intermediate |
|---|---|---|
| ABT-494-001 | 1708997-42-5Available | benzyl (3S,4R)-3-ethyl-4-(3-tosyl-3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)pyrrolidine-1-carboxylate |
| ABT-494-002 | 1428243-28-0Available | 8-((3R,4S)-4-ethylpyrrolidin-3-yl)-3-tosyl-3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazine |
| ABT-494-003 | 753-90-2Available | 2,2,2-trifluoroethan-1-amine |
| ABT-494-004 | - | (3S,4R)-3-ethyl-4-(3-tosyl-3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide |
Frequently asked questions
What are the approved indications of Upadacitinib?
Approved indications include: Alopecia areata, Giant cell arteritis, Ankylosing spondylitis, Spondyloarthritis, Crohn's disease, Non-radiographic axial spondyloarthritis, Ulcerative colitis, Psoriatic arthritis.
When does the Upadacitinib patent expire?
Based on public sources, the Upadacitinib patent expires in 2033.
How many synthesis routes are recorded for Upadacitinib?
1 synthesis routes are recorded; the shortest is 3 steps with / total yield. Intermediates in each route carry codes and CAS numbers.
Where can I buy Upadacitinib intermediates?
3 intermediate CAS of Upadacitinib are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.
How do I get a quote for Upadacitinib intermediates?
Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.
Source: cross-verified data (structured fields only) · 2026-09-29