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Dienogest/Estradiol Valerate
Tier C — Watch / tradeDienogest/Estradiol Valerate
Bayer
Originator
2010
First approval
-
Expiry (public)
No sales data
Peak sales
Small molecule
Type
Targets：ERs, PR
Brand：Natazia
Indications (approved)：Contraception
Regional status
US
Approved
2010-05-06
EU
No progress
2004-04-01
China
No progress
2014-04-29
Japan
-
Factories producing this API9
Factories registered as producing this API in our sourcing network (RFQ records + product master), sorted by RFQ activity; the snapshot carries no cost or customer data.
9 producing factories on file — sign in to view the named list (factory details are not shown to guests).
Sign in to view factories →Synthetic routes & intermediates8 routes
Originator routes × 0Optimised (non-patent) × 8Process routes × 0
Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.
OptimisedRoute 1Steps 3 · Total yield 90g(Estradiol Valerate (Free))
Estradiol Valerate-001—Estradiol Valerate-002—Estradiol Valerate-00363042-28-4Estradiol Valerate-004—API · Dienogest/Estradiol Valerate
| Code | CAS No. | Intermediate |
|---|---|---|
| Estradiol Valerate-001 | - | (17beta)-Estra-1,3,5(10)-triene-3,17-diol |
| Estradiol Valerate-002 | - | Pentanoic anhydride |
| Estradiol Valerate-003 | 63042-28-4 | (17beta)-Estra-1,3,5(10)-triene-3,17-diyl dipentanoate |
| Estradiol Valerate-004 | - | Butanecarboxylic acid |
OptimisedRoute 1Steps 2 · Total yield /
(I)90248-1-a65928-65-6(II)90248-1-a—API · Dienogest/Estradiol Valerate
| Code | CAS No. | Intermediate |
|---|---|---|
| (I)90248-1-a | 65928-65-6 | 2-(17beta-Hydroxy-3-oxoestr-5(10)-en-17-yl)acetonitrile |
| (II)90248-1-a | - | 2-[(10S,11S,14R,15S)-2,7-dibromo-14-hydroxy-15-methyl-5-oxotetracyclo[8.7.0.0(2,7).0(11,15)]heptadecan-14-yl]acetonitrile |
OptimisedRoute 2Steps 4 · Total yield /
(I)90248-2-a17976-32-8(II)90248-2-a—(III)90248-2-a30925-89-4(IV)90248-2-a65928-64-5(V)90248-2-a—(VI)90248-2-a—(VII)90248-2-a—(VIII)90248-2-a75-05-8API · Dienogest/Estradiol Valerate
| Code | CAS No. | Intermediate |
|---|---|---|
| (I)90248-2-a | 17976-32-8 | 3-Methoxyestra-2,5(10)-dien-17-one |
| (II)90248-2-a | - | dimethyl(methylidene)-sulfane |
| (III)90248-2-a | 30925-89-4 | (1'S,2S,10'R,11'S,15'S)-5'-methoxy-15'-methylspiro[oxirane-2,14'-tetracyclo[8.7.0.0(2,7).0(11,15)]heptadecane]-2'(7'),4'-diene |
| (IV)90248-2-a | 65928-64-5 | 2-(17beta-Hydroxy-3-methoxyestra-2,5(10)-dien-17-yl)acetonitrile |
| (V)90248-2-a | - | 2-[(1S,10R,11S,14R,15S)-14-hydroxy-15-methyl-5-oxotetracyclo[8.7.0.0(2,7).0(11,15)]heptadec-2(7)-en-14-yl]acetonitrile |
| (VI)90248-2-a | - | 3,3-Dimethoxyestra-5,9-dien-17-one |
| (VII)90248-2-a | - | 3-Ethoxyestra-3,5,9-trien-17-one |
| (VIII)90248-2-a | 75-05-8 | Acetonitrile anhydrous |
OptimisedRoute 3Steps 4 · Total yield /
(I)90248-3-a5173-46-6(II)90248-3-a126-30-7(III)90248-3-a91175-92-7(IV)90248-3-a1253857-90-7(V)90248-3-a1253857-91-8API · Dienogest/Estradiol Valerate
| Code | CAS No. | Intermediate |
|---|---|---|
| (I)90248-3-a | 5173-46-6 | Estra-4,9-diene-3,17-dione |
| (II)90248-3-a | 126-30-7 | 1,3-Dihydroxy-2,2-dimethylpropane |
| (III)90248-3-a | 91175-92-7 | 3,3-(2,2-Dimethyl-1,3-propylenedioxy)estra-5(10),9(11)-dien-17-one |
| (IV)90248-3-a | 1253857-90-7 | 3,3-(2,2-Dimethyl-1,3-propylenedioxy)-17beta,17beta-(methyleneoxy)estra-5(10),9(11)-diene |
| (V)90248-3-a | 1253857-91-8 | 2-[3,3-(2,2-Dimethyl-1,3-propylenedioxy)-17beta-hydroxyestra-5(10),9(11)-dien-17-yl]acetonitrile |
OptimisedRoute 4Steps 6 · Total yield /
(I)90248-4-a1624-62-0(II)90248-4-a133291-95-9(III)90248-4-a1255910-17-8(IV)90248-4-a17976-32-8(V)90248-4-a65928-64-5(VI)90248-4-a65928-65-6(VII)90248-4-a24284-84-2(VIII)90248-4-a110169-67-0API · Dienogest/Estradiol Valerate
| Code | CAS No. | Intermediate |
|---|---|---|
| (I)90248-4-a | 1624-62-0 | 3-Methoxyestra-1,3,5(10)-trien-17-one |
| (II)90248-4-a | 133291-95-9 | 3,17,17-Trimethoxyestra-1(10),2,4-triene |
| (III)90248-4-a | 1255910-17-8 | 3,17,17-Trimethoxyestra-2,5(10)-diene |
| (IV)90248-4-a | 17976-32-8 | 3-Methoxyestra-2,5(10)-dien-17-one |
| (V)90248-4-a | 65928-64-5 | 2-(17beta-Hydroxy-3-methoxyestra-2,5(10)-dien-17-yl)acetonitrile |
| (VI)90248-4-a | 65928-65-6 | 2-(17beta-Hydroxy-3-oxoestr-5(10)-en-17-yl)acetonitrile |
| (VII)90248-4-a | 24284-84-2 | 2-(17beta-Hydroxy-3-methoxyestra-1(10),2,4-trien-17-yl)acetonitrile |
| (VIII)90248-4-a | 110169-67-0 | 3-Methoxyestra-2,5(10)-dien-17-ol |
OptimisedRoute 5Steps 2 · Total yield /
(I)90248-5-a10109-76-9(II)90248-5-a75-05-8(III)90248-5-a102193-41-9API · Dienogest/Estradiol Valerate
| Code | CAS No. | Intermediate |
|---|---|---|
| (I)90248-5-a | 10109-76-9 | 3,3-Dimethoxyestra-5(10),9(11)-dien-17-one |
| (II)90248-5-a | 75-05-8 | Acetonitrile anhydrous |
| (III)90248-5-a | 102193-41-9 | 17alpha-(Cyanomethyl)-3,3-dimethoxy-13beta-methylgonane-5(10),9(11)-dien-17beta-ol |
OptimisedRoute 6Steps 2 · Total yield /
(III)90248-6-a190662-30-7(I)90248-6-a5571-36-8(II)90248-6-a75-05-8API · Dienogest/Estradiol Valerate
| Code | CAS No. | Intermediate |
|---|---|---|
| (III)90248-6-a | 190662-30-7 | [(8S,13S,14S,17R)-17-Hydroxy-13-methyl-1,2,4,6,7,8,12,13,14,15,16,17-dodecahydrospiro[cyclopenta[a]phenanthrene-3,2'-[1,3]dioxolan]-17-yl]acetonitrile |
| (I)90248-6-a | 5571-36-8 | 17-Oxo-estradiene |
| (II)90248-6-a | 75-05-8 | Acetonitrile anhydrous |
OptimisedRoute 7Steps 4 · Total yield /
(Ia)125457-3-a88128-57-8(Ib)125457-3-a88128-58-9(II)125457-3-a1700622-26-9(III)125457-3-a1700616-94-9(IV)125457-3-a88128-63-6(V)125457-3-a88128-61-4(VI)125457-3-a5173-46-6API · Dienogest/Estradiol Valerate
| Code | CAS No. | Intermediate |
|---|---|---|
| (Ia)125457-3-a | 88128-57-8 | 2-(3-Chloropropyl)-2,5,5-trimethyl-1,3-dioxane |
| (Ib)125457-3-a | 88128-58-9 | 2-(3-Bromopropyl)-2,5,5-trimethyl-1,3-dioxane |
| (II)125457-3-a | 1700622-26-9 | (6aS,9aS,9bS)-6a-Methyldecahydrocyclopenta[f]chromene-3,7-dione |
| (III)125457-3-a | 1700616-94-9 | (3aS,4S,7aS)-5-Hydroxy-7a-methyl-4-[3-oxo-6-(2,5,5-trimethyl-1,3-dioxan-2-yl)hexyl]octahydro-1H-inden-1-one |
| (IV)125457-3-a | 88128-63-6 | (3aS,4S,7aS)-7a-Methyl-4-[3-oxo-6-(2,5,5-trimethyl-1,3-dioxan-2-yl)hexyl]hexahydro-1H-indene-1,5(4H)-dione |
| (V)125457-3-a | 88128-61-4 | (3aS,9aS,9bS)-3a-Methyl-6-[2-(2,5,5-trimethyl-1,3-dioxan-2-yl)ethyl]-4,5,8,9,9a,9b-hexahydro-1H-cyclopenta[a]naphthalene-3,7(2H,3aH)-dione |
| (VI)125457-3-a | 5173-46-6 | Estra-4,9-diene-3,17-dione |
Frequently asked questions
What are the approved indications of Dienogest/Estradiol Valerate?
Approved indications include: Contraception.
When does the Dienogest/Estradiol Valerate patent expire?
No public expiry year is available for Dienogest/Estradiol Valerate yet; this page updates once verified.
How many synthesis routes are recorded for Dienogest/Estradiol Valerate?
8 synthesis routes are recorded; the shortest is 2 steps with / total yield. Intermediates in each route carry codes and CAS numbers.
Where can I buy Dienogest/Estradiol Valerate intermediates?
All intermediates in Dienogest/Estradiol Valerate routes have CAS profiles — you can submit an RFQ per CAS and it enters the Unibest matching pool.
How do I get a quote for Dienogest/Estradiol Valerate intermediates?
Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.
Source: cross-verified data (structured fields only) · 2026-09-29