Pramipexole Dihydrochloride Hydrate
Tier C — Watch / tradePramipexole Dihydrochloride Hydrate
Targets：DRD2, DRD4, DRD3
Brand：Mirapex-ER, Sifrol, Mirapex, BI-Sifrol, Mirapex-LA, Mirapexin
Indications (approved)：Restless legs syndrome, Parkinson's disease
Regional status
Synthetic routes & intermediates5 routes
Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.
| Code | CAS No. | Intermediate |
|---|---|---|
| PRAM-001 | 27514-08-5 | N-(4-oxocyclohexyl)acetamide |
| PRAM-002 | 104617-51-8 | N-(2-amino-4,5,6,7-tetrahydrobenzo[d]thiazol-6-yl)acetamide |
| PRAM-003 | 104617-49-4 | - |
| PRAM-004 | 106092-09-5 | (S)-4,5,6,7-tetrahydrobenzo[d]thiazole-2,6-diamine |
| PRAM-005 | 106006-84-2 | (S)-N-(2-amino-4,5,6,7-tetrahydrobenzo[d]thiazol-6-yl)propionamide |
| Code | CAS No. | Intermediate |
|---|---|---|
| PRAM-006 | 104618-32-8 | 2-(4-oxocyclohexyl)isoindoline-1,3-dione |
| PRAM-007 | 104618-33-9 | 2-(2-amino-4,5,6,7-tetrahydrobenzo[d]thiazol-6-yl)isoindoline-1,3-dione |
| PRAM-008 | 104617-49-4 | - |
| Code | CAS No. | Intermediate |
|---|---|---|
| PRAM-004 | 106092-09-5 | (S)-4,5,6,7-tetrahydrobenzo[d]thiazole-2,6-diamine |
| PRAM-007 | 104618-33-9 | 2-(2-amino-4,5,6,7-tetrahydrobenzo[d]thiazol-6-yl)isoindoline-1,3-dione |
| PRAM-008 | 104617-49-4 | - |
| PRAM-009 | 104618-31-7 | 2-(4-hydroxycyclohexyl)isoindoline-1,3-dione |
| PRAM-010 | 873431-80-2 | 4,5,6,7-tetrahydrobenzo[d]thiazole-2,6-diamine (2R,3R)-2,3-dihydroxysuccinate |
| crude Pramipexole | 104632-26-0 | (S)-N6-propyl-4,5,6,7-tetrahydrobenzo[d]thiazole-2,6-diamine |
| Code | CAS No. | Intermediate |
|---|---|---|
| PRAM-004 | 106092-09-5 | (S)-4,5,6,7-tetrahydrobenzo[d]thiazole-2,6-diamine |
| PRAM-011 | 1694-92-4 | 2-nitrobenzenesulfonyl chloride |
| PRAM-012 | 1046124-79-1 | (S)-N-(2-amino-4,5,6,7-tetrahydrobenzo[d]thiazol-6-yl)-2-nitrobenzenesulfonamide |
| Code | CAS No. | Intermediate |
|---|---|---|
| PRAM-008 | 104617-49-4 | - |
| PRAM-013 | - | (R)-N-(6-hydroxy-4,5,6,7-tetrahydrobenzo[d]thiazol-2-yl)acetamide |
| PRAM-014 | 1628866-42-1 | (R)-2-acetamido-4,5,6,7-tetrahydrobenzo[d]thiazol-6-yl 4-methylbenzenesulfonate |
| PRAM-015 | 1628866-43-2 | (S)-N-(6-azido-4,5,6,7-tetrahydrobenzo[d]thiazol-2-yl)acetamide |
| PRAM-016 | - | (S)-N-(6-amino-4,5,6,7-tetrahydrobenzo[d]thiazol-2-yl)acetamide |
| PRAM-017 | 599-91-7 | propyl 4-methylbenzenesulfonate |
Frequently asked questions
What are the approved indications of Pramipexole Dihydrochloride Hydrate?
Approved indications include: Restless legs syndrome, Parkinson's disease.
When does the Pramipexole Dihydrochloride Hydrate patent expire?
No public expiry year is available for Pramipexole Dihydrochloride Hydrate yet; this page updates once verified.
How many synthesis routes are recorded for Pramipexole Dihydrochloride Hydrate?
5 synthesis routes are recorded; the shortest is 2 steps with 950.00-980.00 mg total yield. Intermediates in each route carry codes and CAS numbers.
Where can I buy Pramipexole Dihydrochloride Hydrate intermediates?
All intermediates in Pramipexole Dihydrochloride Hydrate routes have CAS profiles — you can submit an RFQ per CAS and it enters the Unibest matching pool.
How do I get a quote for Pramipexole Dihydrochloride Hydrate intermediates?
Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.
Source: cross-verified data (structured fields only) · 2026-09-29