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Atorvastatin Calcium Hydrate/Ramipril
Tier C — Watch / tradeAtorvastatin Calcium Hydrate/Ramipril
Dr. Reddy's Laboratories Ltd.
Originator
2008
First approval
-
Expiry (public)
No sales data
Peak sales
Small molecule
Type
Targets：ACE, HMGCR
Brand：Atocor-R
Indications (approved)：Hypercholesterolaemia, Hypertension
Regional status
US
-
EU
-
China
-
Japan
-
Factories producing this API12
Factories registered as producing this API in our sourcing network (RFQ records + product master), sorted by RFQ activity; the snapshot carries no cost or customer data.
12 producing factories on file — sign in to view the named list (factory details are not shown to guests).
Sign in to view factories →Synthetic routes & intermediates20 routes
Originator routes × 1Optimised (non-patent) × 16Process routes × 3
Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.
OriginatorRoute 1Steps 11 · Total yield /
ATOR-001712-52-7ATOR-0025754-35-8ATOR-003110862-42-5ATOR-00479-30-1ATOR-005110862-44-7ATOR-0067342-2-1ATOR-007110862-45-8ATOR-008110862-46-9ATOR-0091429437-86-4ATOR-010134523-00-5ATOR-011125995-03-1ATOR-0123886-69-9ATOR-013—ATOR-014125995-03-1ATOR-015134523-01-6API · Atorvastatin Calcium Hydrate/Ramipril
| Code | CAS No. | Intermediate |
|---|---|---|
| ATOR-001 | 712-52-7 | ethyl 2-bromo-2-(4-fluorophenyl)acetate |
| ATOR-002 | 5754-35-8 | 2-(1,3-dioxolan-2-yl)ethanamine |
| ATOR-003 | 110862-42-5 | ethyl 2-((2-(1,3-dioxolan-2-yl)ethyl)amino)-2-(4-fluorophenyl)acetate |
| ATOR-004 | 79-30-1Available | isobutyryl chloride |
| ATOR-005 | 110862-44-7 | 2-(N-(2-(1,3-dioxolan-2-yl)ethyl)isobutyramido)-2-(4-fluorophenyl)acetic acid |
| ATOR-006 | 7342-2-1 | N,3-diphenylpropiolamide |
| ATOR-007 | 110862-45-8 | 1-(2-(1,3-dioxolan-2-yl)ethyl)-5-(4-fluorophenyl)-2-isopropyl-N,4-diphenyl-1H-pyrrole-3-carboxamide |
| ATOR-008 | 110862-46-9 | 5-(4-fluorophenyl)-2-isopropyl-1-(3-oxopropyl)-N,4-diphenyl-1H-pyrrole-3-carboxamide |
| ATOR-009 | 1429437-86-4 | methyl 7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-5-hydroxy-3-oxoheptanoate |
| ATOR-010 | 134523-00-5 | (3R,5R)-7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoic acid |
| ATOR-011 | 125995-03-1 | 5-(4-fluorophenyl)-1-(2-((2R,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl)ethyl)-2-isopropyl-N,4-diphenyl-1H-pyrrole-3-carboxamide |
| ATOR-012 | 3886-69-9Available | (R)-1-phenylethan-1-amine |
| ATOR-013 | - | 1-((3R,5R)-3,5-dihydroxy-7-oxo-7-(((R)-1-phenylethyl)amino)heptyl)-5-(4-fluorophenyl)-2-isopropyl-N,4-diphenyl-1H-pyrrole-3-carboxamide |
| ATOR-014 | 125995-03-1 | 5-(4-fluorophenyl)-1-(2-((2R,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl)ethyl)-2-isopropyl-N,4-diphenyl-1H-pyrrole-3-carboxamide |
| ATOR-015 | 134523-01-6 | sodium (3R,5R)-7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate |
OptimisedRoute 2Steps 8 · Total yield /
ATOR-015134523-01-6ATOR-016—ATOR-017519-87-9ATOR-018156051-77-3ATOR-019156051-78-4ATOR-02077-76-9ATOR-021156051-79-5ATOR-022156051-80-8ATOR-023125971-96-2ATOR-024156051-81-9ATOR-025156051-82-0API · Atorvastatin Calcium Hydrate/Ramipril
| Code | CAS No. | Intermediate |
|---|---|---|
| ATOR-015 | 134523-01-6 | sodium (3R,5R)-7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate |
| ATOR-016 | - | (R)-ethyl 6-cyano-5-hydroxy-3-oxohexanoate |
| ATOR-017 | 519-87-9 | N,N-diphenylacetamide |
| ATOR-018 | 156051-77-3 | (R)-6-cyano-5-hydroxy-3-oxo-N,N-diphenylhexanamide |
| ATOR-019 | 156051-78-4 | (3R,5R)-6-cyano-3,5-dihydroxy-N,N-diphenylhexanamide |
| ATOR-020 | 77-76-9Available | 2,2-dimethoxypropane |
| ATOR-021 | 156051-79-5 | 2-((4R,6R)-6-(cyanomethyl)-2,2-dimethyl-1,3-dioxan-4-yl)-N,N-diphenylacetamide |
| ATOR-022 | 156051-80-8 | 2-((4R,6R)-6-(2-aminoethyl)-2,2-dimethyl-1,3-dioxan-4-yl)-N,N-diphenylacetamide |
| ATOR-023 | 125971-96-2 | 2-(2-(4-fluorophenyl)-2-oxo-1-phenylethyl)-4-methyl-3-oxo-N-phenylpentanamide |
| ATOR-024 | 156051-81-9 | 1-(2-((4R,6R)-6-(2-(diphenylamino)-2-oxoethyl)-2,2-dimethyl-1,3-dioxan-4-yl)ethyl)-5-(4-fluorophenyl)-2-isopropyl-N,4-diphenyl-1H-pyrrole-3-carboxamide |
| ATOR-025 | 156051-82-0 | 1-((3R,5R)-7-(diphenylamino)-3,5-dihydroxy-7-oxoheptyl)-5-(4-fluorophenyl)-2-isopropyl-N,4-diphenyl-1H-pyrrole-3-carboxamide |
OptimisedRoute 3Steps 8 · Total yield /
ATOR-015134523-01-6ATOR-02077-76-9ATOR-023125971-96-2ATOR-026105876-28-6ATOR-02780297-45-6ATOR-028125971-92-8ATOR-029125971-93-9ATOR-030125971-94-0ATOR-031125995-13-3ATOR-032125971-95-1ATOR-033134395-00-9API · Atorvastatin Calcium Hydrate/Ramipril
| Code | CAS No. | Intermediate |
|---|---|---|
| ATOR-015 | 134523-01-6 | sodium (3R,5R)-7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate |
| ATOR-020 | 77-76-9Available | 2,2-dimethoxypropane |
| ATOR-023 | 125971-96-2 | 2-(2-(4-fluorophenyl)-2-oxo-1-phenylethyl)-4-methyl-3-oxo-N-phenylpentanamide |
| ATOR-026 | 105876-28-6 | (R)-3-((tert-butyldimethylsilyl)oxy)-4-cyanobutanoic acid |
| ATOR-027 | 80297-45-6 | monomagnesium mono(3-(tert-butoxy)-3-oxopropanoate) |
| ATOR-028 | 125971-92-8 | (R)-tert-butyl 5-((tert-butyldimethylsilyl)oxy)-6-cyano-3-oxohexanoate |
| ATOR-029 | 125971-93-9 | (3R,5R)-tert-butyl 6-cyano-3,5-dihydroxyhexanoate |
| ATOR-030 | 125971-94-0 | tert-butyl 2-((4R,6R)-6-(cyanomethyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate |
| ATOR-031 | 125995-13-3 | tert-butyl 2-((4R,6R)-6-(2-aminoethyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate |
| ATOR-032 | 125971-95-1 | tert-butyl 2-((4R,6R)-6-(2-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)ethyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate |
| ATOR-033 | 134395-00-9 | (3R,5R)-tert-butyl 7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate |
OptimisedRoute 4Steps 14 · Total yield /
ATOR-015134523-01-6ATOR-023125971-96-2ATOR-03432328-03-3ATOR-03581927-55-1ATOR-036838906-52-8ATOR-0371404189-41-8ATOR-038838906-36-8ATOR-039—ATOR-040112904-69-5ATOR-041105-34-0ATOR-0421443774-74-0ATOR-0431443774-76-2ATOR-0441417187-90-6ATOR-045676260-68-7ATOR-046714963-28-7ATOR-047676260-66-5ATOR-0481353049-81-6ATOR-049345891-62-5API · Atorvastatin Calcium Hydrate/Ramipril
| Code | CAS No. | Intermediate |
|---|---|---|
| ATOR-015 | 134523-01-6 | sodium (3R,5R)-7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate |
| ATOR-023 | 125971-96-2 | 2-(2-(4-fluorophenyl)-2-oxo-1-phenylethyl)-4-methyl-3-oxo-N-phenylpentanamide |
| ATOR-034 | 32328-03-3 | diethyl 3-hydroxypentanedioate |
| ATOR-035 | 81927-55-1 | benzyl 2,2,2-trichloroacetimidate |
| ATOR-036 | 838906-52-8 | diethyl 3-(benzyloxy)pentanedioate |
| ATOR-037 | 1404189-41-8 | 3-(benzyloxy)pentanedioic acid |
| ATOR-038 | 838906-36-8 | 4-(benzyloxy)dihydro-2H-pyran-2,6(3H)-dione |
| ATOR-039 | - | - |
| ATOR-040 | 112904-69-5 | (R)-3-(benzyloxy)-5-methoxy-5-oxopentanoic acid |
| ATOR-041 | 105-34-0Available | methyl 2-cyanoacetate |
| ATOR-042 | 1443774-74-0 | (5R)-dimethyl 5-(benzyloxy)-2-cyano-3-oxoheptanedioate |
| ATOR-043 | 1443774-76-2 | (R)-methyl 3-(benzyloxy)-6-cyano-5-oxohexanoate |
| ATOR-044 | 1417187-90-6 | (R)-methyl 6-cyano-3-hydroxy-5-oxohexanoate |
| ATOR-045 | 676260-68-7 | (3R,5R)-methyl 6-cyano-3,5-dihydroxyhexanoate |
| ATOR-046 | 714963-28-7 | methyl 2-((4R,6R)-6-(cyanomethyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate |
| ATOR-047 | 676260-66-5 | methyl 2-((4R,6R)-6-(2-aminoethyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate |
| ATOR-048 | 1353049-81-6 | methyl 2-((4R,6R)-6-(2-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)ethyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate |
| ATOR-049 | 345891-62-5 | (3R,5R)-methyl 7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate |
OptimisedRoute 5Steps 9 · Total yield 54.80 mg
ATOR-023125971-96-2ATOR-031125995-13-3ATOR-032125971-95-1ATOR-033134395-00-9ATOR-05019790-60-4ATOR-0511182707-33-0ATOR-052129648-07-3ATOR-0531320208-68-1ATOR-0541331869-16-9ATOR-0551347738-07-1ATOR-05653503-61-0ATOR-0571331869-20-5ATOR-0581331869-21-6ATOR-0591331869-22-7API · Atorvastatin Calcium Hydrate/Ramipril
| Code | CAS No. | Intermediate |
|---|---|---|
| ATOR-023 | 125971-96-2 | 2-(2-(4-fluorophenyl)-2-oxo-1-phenylethyl)-4-methyl-3-oxo-N-phenylpentanamide |
| ATOR-031 | 125995-13-3 | tert-butyl 2-((4R,6R)-6-(2-aminoethyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate |
| ATOR-032 | 125971-95-1 | tert-butyl 2-((4R,6R)-6-(2-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)ethyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate |
| ATOR-033 | 134395-00-9 | (3R,5R)-tert-butyl 7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate |
| ATOR-050 | 19790-60-4 | 3-(benzyloxy)propanal |
| ATOR-051 | 1182707-33-0 | - |
| ATOR-052 | 129648-07-3 | 1,2-bis((2R,5R)-2,5-dimethylphospholan-1-yl)ethane |
| ATOR-053 | 1320208-68-1 | lithium 2,2,5,7,8-pentamethylchroman-6-olate |
| ATOR-054 | 1331869-16-9 | - |
| ATOR-055 | 1347738-07-1 | - |
| ATOR-056 | 53503-61-0 | lithium 1-(tert-butoxy)ethenolate |
| ATOR-057 | 1331869-20-5 | (R)-tert-butyl 7-(benzyloxy)-5-((tert-butyldimethylsilyl)oxy)-3-oxoheptanoate |
| ATOR-058 | 1331869-21-6 | tert-butyl 2-((4R,6R)-6-(2-(benzyloxy)ethyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate |
| ATOR-059 | 1331869-22-7 | tert-butyl 2-((4R,6R)-2,2-dimethyl-6-(2-(tosyloxy)ethyl)-1,3-dioxan-4-yl)acetate |
OptimisedRoute 2Steps 4 · Total yield /
Ramipril-00387269-85-0Ramipril-00887269-87-2Ramipril-0101375192-85-0Ramipril-011811420-40-3Ramipril-0121375193-05-7Ramipril-013—Ramipril-0141375193-06-8API · Atorvastatin Calcium Hydrate/Ramipril
| Code | CAS No. | Intermediate |
|---|---|---|
| Ramipril-003 | 87269-85-0 | (Methyl 2-(acetylamino)-3-(2-oxocyclopentyl)propanoate) |
| Ramipril-008 | 87269-87-2 | Benzyl (2S,3aS,6aS)-octahydrocyclopenta[b]pyrrole-2-carboxylate hydrochloride |
| Ramipril-010 | 1375192-85-0 | N-Acetyl-3-(2-oxocyclopentyl)-L-alanine |
| Ramipril-011 | 811420-40-3 | (2S)-2,3,3a,4,5,6-Hexahydrocyclopenta[b]pyrrole-2-carboxylic acid hydrochloride |
| Ramipril-012 | 1375193-05-7 | (2S)-2,3,3a,4,5,6-Hexahydrocyclopenta[b]pyrrole-2-carboxylic acid 4-methylbenzenesulfonate |
| Ramipril-013 | - | (2S,3aR,6aS)-octahydrocyclopenta[b]pyrrole-2-carboxylic acid hydrochloride |
| Ramipril-014 | 1375193-06-8 | (2S,3aS,6aS)-Octahydrocyclopenta[b]pyrrole-2-carboxylic acid 4-methylbenzenesulfonate |
OptimisedRoute 3Steps 8 · Total yield 65g(Ramipril-010)
Ramipril-00487269-86-1Ramipril-015—Ramipril-016—Ramipril-0172231630-58-1Ramipril-018—Ramipril-019—Ramipril-020—Ramipril-021495-69-2Ramipril-022—Ramipril-023—Ramipril-024—Ramipril-025—Ramipril-026—Ramipril-027—Ramipril-028—Ramipril-029—API · Atorvastatin Calcium Hydrate/Ramipril
| Code | CAS No. | Intermediate |
|---|---|---|
| Ramipril-004 | 87269-86-1 | (2S,3aS,6aS)-Octahydrocyclopenta[b]pyrrole-2-carboxylic acid hydrochloride |
| Ramipril-015 | - | 2-Acetamidoacetic acid |
| Ramipril-016 | - | Formyldimethylamine |
| Ramipril-017 | 2231630-58-1 | 4-[(Dimethylamino)methylidene]-2-methyl-1,3-oxazol-5(4H)-one |
| Ramipril-018 | - | Sodium (2-methyl-5-oxo-1,3-oxazol-4(5H)-ylidene)methanolate |
| Ramipril-019 | - | (2-Methyl-5-oxo-1,3-oxazol-4(5H)-ylidene)methyl acetate |
| Ramipril-020 | - | 4-(Ethoxymethylidene)-2-phenyl-1,3-oxazol-5(4H)-one |
| Ramipril-021 | 495-69-2 | 2-(Phenylformamido)Acetic Acid |
| Ramipril-022 | - | (Diethoxymethoxy)ethane |
| Ramipril-023 | - | 1-Morpholinocyclopentene |
| Ramipril-024 | - | 2-Methyl-4-[[2-(morpholin-4-yl)cyclopent-1-en-1-yl]methylidene]-1,3-oxazol-5(4H)-one |
| Ramipril-025 | - | 4-[[2-(Morpholin-4-yl)cyclopent-1-en-1-yl]methylidene]-2-phenyl-1,3-oxazol-5(4H)-one |
| Ramipril-026 | - | Methyl 2-benzamido-3-[2-(morpholin-4-yl)cyclopent-1-en-1-yl]prop-2-enoate |
| Ramipril-027 | - | Methyl 2-acetamido-3-[2-(morpholin-4-yl)cyclopent-1-en-1-yl]prop-2-enoate |
| Ramipril-028 | - | Methyl N-benzoyl-3-[2-(morpholin-4-yl)cyclopent-1-en-1-yl]-L-alaninate |
| Ramipril-029 | - | Methyl N-acetyl-3-[2-(morpholin-4-yl)cyclopent-1-en-1-yl]-L-alaninate |
OptimisedRoute 4Steps 2 · Total yield /
Ramipril-030—Ramipril-00887269-87-2Ramipril-03184793-24-8Ramipril-00787269-88-3API · Atorvastatin Calcium Hydrate/Ramipril
| Code | CAS No. | Intermediate |
|---|---|---|
| Ramipril-030 | - | Benzyl (2S,3aS,6aS)-octahydrocyclopenta[b]pyrrole-2-carboxylate |
| Ramipril-008 | 87269-87-2 | Benzyl (2S,3aS,6aS)-octahydrocyclopenta[b]pyrrole-2-carboxylate hydrochloride |
| Ramipril-031 | 84793-24-8 | Ethyl (2S)-2-[(4S)-4-methyl-2,5-dioxo-1,3-oxazolidin-3-yl]-4-phenylbutanoate |
| Ramipril-007 | 87269-88-3 | (2S,3aS,6aS)-1-[N-[1(S)-(Ethoxycarbonyl)-3-phenylpropyl]-L-alanyl]perhydrocyclopenta[b]pyrrole-2-carboxylic acid |
OptimisedRoute 5Steps 1 · Total yield /
Ramipril-032—Ramipril-033—API · Atorvastatin Calcium Hydrate/Ramipril
| Code | CAS No. | Intermediate |
|---|---|---|
| Ramipril-032 | - | (2S)-octahydrocyclopenta[b]pyrrole-2-carboxylic acid |
| Ramipril-033 | - | (2S,3aS,6aS)-Octahydrocyclopenta[b]pyrrole-2-carboxylic acid |
OptimisedRoute 6Steps 7 · Total yield 19g(Ramipril (Free))
Ramipril-034859799-38-5Ramipril-001—Ramipril-035—Ramipril-036—Ramipril-0371030838-82-4Ramipril-038812630-31-2Ramipril-033—Ramipril-039—Ramipril-040172542-27-7Ramipril-04184793-24-8Ramipril-00787269-88-3API · Atorvastatin Calcium Hydrate/Ramipril
| Code | CAS No. | Intermediate |
|---|---|---|
| Ramipril-034 | 859799-38-5 | methyl 3-chloro-2-(2-phenylacetamido)propanoate |
| Ramipril-001 | - | 1-(1-Cyclopentenyl)pyrrolidine |
| Ramipril-035 | - | methyl 3-(2-oxocyclopentyl)-2-(2-phenylacetamido)propanoate |
| Ramipril-036 | - | 3-(2-oxocyclopentyl)-2-(2-phenylacetamido)propanoic acid |
| Ramipril-037 | 1030838-82-4 | 3-(2-Oxocyclopentyl)-L-alanine |
| Ramipril-038 | 812630-31-2 | (2S)-2,3,3a,4,5,6-Hexahydrocyclopenta[b]pyrrole-2-carboxylic acid |
| Ramipril-033 | - | (2S,3aS,6aS)-Octahydrocyclopenta[b]pyrrole-2-carboxylic acid |
| Ramipril-039 | - | 1-Phenylmethanol |
| Ramipril-040 | 172542-27-7 | N'-[(1E)-{6-[(2S)-2-hydroxypropyl]-2H-1,3-benzodioxol-5-yl}(4-nitrophenyl)methylidene]acetohydrazide |
| Ramipril-041 | 84793-24-8 | Ethyl (2S)-2-[(4S)-4-methyl-2,5-dioxo-1,3-oxazolidin-3-yl]-4-phenylbutanoate |
| Ramipril-007 | 87269-88-3 | (2S,3aS,6aS)-1-[N-[1(S)-(Ethoxycarbonyl)-3-phenylpropyl]-L-alanyl]perhydrocyclopenta[b]pyrrole-2-carboxylic acid |
OptimisedRoute 7Steps 4 · Total yield 27.3g(Ramipril (Free))
Ramipril-006—Ramipril-042—Ramipril-043957299-56-8Ramipril-04184793-24-8Ramipril-030—Ramipril-00787269-88-3API · Atorvastatin Calcium Hydrate/Ramipril
| Code | CAS No. | Intermediate |
|---|---|---|
| Ramipril-006 | - | N-[(S)-(+)-1-(Ethoxycarbonyl)-3-phenylpropyl]-L-alanine |
| Ramipril-042 | - | Carbonochloridic acid ethyl ester |
| Ramipril-043 | 957299-56-8 | ethyl (2S)-2-[(ethoxycarbonyl)[(2S)-1-[(ethoxycarbonyl)oxy]-1-oxopropan-2-yl]amino]-4-phenylbutanoate |
| Ramipril-041 | 84793-24-8 | Ethyl (2S)-2-[(4S)-4-methyl-2,5-dioxo-1,3-oxazolidin-3-yl]-4-phenylbutanoate |
| Ramipril-030 | - | Benzyl (2S,3aS,6aS)-octahydrocyclopenta[b]pyrrole-2-carboxylate |
| Ramipril-007 | 87269-88-3 | (2S,3aS,6aS)-1-[N-[1(S)-(Ethoxycarbonyl)-3-phenylpropyl]-L-alanyl]perhydrocyclopenta[b]pyrrole-2-carboxylic acid |
OptimisedRoute 8Steps 9 · Total yield 4.56g(Ramipril (Free))
Ramipril-0441143952-13-9Ramipril-0451143952-11-7Ramipril-001—Ramipril-0461143952-17-3Ramipril-0471143952-08-2Ramipril-00387269-85-0Ramipril-0371030838-82-4Ramipril-033—Ramipril-048852546-84-0Ramipril-049114192-42-6Ramipril-006—API · Atorvastatin Calcium Hydrate/Ramipril
| Code | CAS No. | Intermediate |
|---|---|---|
| Ramipril-044 | 1143952-13-9 | Propyl L-serinate hydrochloride |
| Ramipril-045 | 1143952-11-7 | N-Acetyl-3-chloro-L-alanine propyl ester |
| Ramipril-001 | - | 1-(1-Cyclopentenyl)pyrrolidine |
| Ramipril-046 | 1143952-17-3 | N-Acetyl-3-(2-oxocyclopentyl)alanine propyl ester |
| Ramipril-047 | 1143952-08-2 | N-Carbamoyl-3-(2-oxocyclopentyl)alanine |
| Ramipril-003 | 87269-85-0 | (Methyl 2-(acetylamino)-3-(2-oxocyclopentyl)propanoate) |
| Ramipril-037 | 1030838-82-4 | 3-(2-Oxocyclopentyl)-L-alanine |
| Ramipril-033 | - | (2S,3aS,6aS)-Octahydrocyclopenta[b]pyrrole-2-carboxylic acid |
| Ramipril-048 | 852546-84-0 | Benzyl (2S,3aS,6aS)-octahydrocyclopenta[b]pyrrole-2-carboxylate 4-methylbenzenesulfonate |
| Ramipril-049 | 114192-42-6 | Ethyl (2S)-2-[[(2S)-1-chloro-1-oxopropan-2-yl]amino]-4-phenylbutanoate hydrochloride |
| Ramipril-006 | - | N-[(S)-(+)-1-(Ethoxycarbonyl)-3-phenylpropyl]-L-alanine |
OptimisedRoute 9Steps 6 · Total yield 11.8g(Ramipril (Free))
Ramipril-0501030838-88-0Ramipril-0371030838-82-4Ramipril-033—Ramipril-00887269-87-2Ramipril-030—Ramipril-049114192-42-6Ramipril-006—API · Atorvastatin Calcium Hydrate/Ramipril
| Code | CAS No. | Intermediate |
|---|---|---|
| Ramipril-050 | 1030838-88-0 | 5-[(2-Oxocyclopentyl)methyl]imidazolidine-2,4-dione |
| Ramipril-037 | 1030838-82-4 | 3-(2-Oxocyclopentyl)-L-alanine |
| Ramipril-033 | - | (2S,3aS,6aS)-Octahydrocyclopenta[b]pyrrole-2-carboxylic acid |
| Ramipril-008 | 87269-87-2 | Benzyl (2S,3aS,6aS)-octahydrocyclopenta[b]pyrrole-2-carboxylate hydrochloride |
| Ramipril-030 | - | Benzyl (2S,3aS,6aS)-octahydrocyclopenta[b]pyrrole-2-carboxylate |
| Ramipril-049 | 114192-42-6 | Ethyl (2S)-2-[[(2S)-1-chloro-1-oxopropan-2-yl]amino]-4-phenylbutanoate hydrochloride |
| Ramipril-006 | - | N-[(S)-(+)-1-(Ethoxycarbonyl)-3-phenylpropyl]-L-alanine |
OptimisedRoute 10Steps 1 · Total yield /
Ramipril-0511342316-06-6Ramipril-0521342316-08-8API · Atorvastatin Calcium Hydrate/Ramipril
| Code | CAS No. | Intermediate |
|---|---|---|
| Ramipril-051 | 1342316-06-6 | Methyl (2Z)-2-(benzoylamino)-3-(2-chlorocyclopent-1-en-1-yl)acrylate |
| Ramipril-052 | 1342316-08-8 | Methyl N-benzoyl-3-(2-chlorocyclopent-1-en-1-yl)-L-alaninate |
OptimisedRoute 11Steps 1 · Total yield 219.3g(Ramipril-055)
Ramipril-0531803175-84-9Ramipril-0521342316-08-8Ramipril-054811420-39-0Ramipril-0551342316-12-4API · Atorvastatin Calcium Hydrate/Ramipril
| Code | CAS No. | Intermediate |
|---|---|---|
| Ramipril-053 | 1803175-84-9 | Methyl N-acetyl-3-(2-chlorocyclopent-1-en-1-yl)-L-alaninate |
| Ramipril-052 | 1342316-08-8 | Methyl N-benzoyl-3-(2-chlorocyclopent-1-en-1-yl)-L-alaninate |
| Ramipril-054 | 811420-39-0 | Methyl N-acetyl-3-(2-oxocyclopentyl)-L-alaninate |
| Ramipril-055 | 1342316-12-4 | Methyl N-benzoyl-3-(2-oxocyclopentyl)-L-alaninate |
OptimisedRoute 12Steps 5 · Total yield 19.67g(Ramipril-008)
Ramipril-056—Ramipril-057—Ramipril-058—Ramipril-05923115-42-6Ramipril-06038524-17-3Ramipril-023—Ramipril-001—Ramipril-061—Ramipril-0621802682-26-3Ramipril-0631802682-27-4Ramipril-00887269-87-2API · Atorvastatin Calcium Hydrate/Ramipril
| Code | CAS No. | Intermediate |
|---|---|---|
| Ramipril-056 | - | 2-Oxopropionic acid ethyl ester |
| Ramipril-057 | - | Acetamide |
| Ramipril-058 | - | Benzamide |
| Ramipril-059 | 23115-42-6 | Ethyl 2-acetamidoacrylate |
| Ramipril-060 | 38524-17-3 | Ethyl 2-(benzoylamino)acrylate |
| Ramipril-023 | - | 1-Morpholinocyclopentene |
| Ramipril-001 | - | 1-(1-Cyclopentenyl)pyrrolidine |
| Ramipril-061 | - | Cyclopentanone |
| Ramipril-062 | 1802682-26-3 | Ethyl N-acetyl-3-(2-oxocyclopentyl)alaninate |
| Ramipril-063 | 1802682-27-4 | Ethyl N-benzoyl-3-(2-oxocyclopentyl)alaninate |
| Ramipril-008 | 87269-87-2 | Benzyl (2S,3aS,6aS)-octahydrocyclopenta[b]pyrrole-2-carboxylate hydrochloride |
OptimisedRoute 13Steps 6 · Total yield 3.33g(Ramipril-074)
Ramipril-064—Ramipril-065—Ramipril-066—Ramipril-0671239450-42-0Ramipril-0681239450-42-0Ramipril-06955299-57-5Ramipril-07024153-31-9Ramipril-06038524-17-3Ramipril-071—Ramipril-023—Ramipril-061—Ramipril-0721802682-27-4Ramipril-0631802682-27-4Ramipril-00387269-85-0Ramipril-073—Ramipril-074—API · Atorvastatin Calcium Hydrate/Ramipril
| Code | CAS No. | Intermediate |
|---|---|---|
| Ramipril-064 | - | (+/-)-2-Amino-3-hydroxypropionic acid |
| Ramipril-065 | - | DL-Serine methyl ester hydrochloride |
| Ramipril-066 | - | Ethyl serinate hydrogen chloride |
| Ramipril-067 | 1239450-42-0 | 2-Benzamido-3-ethoxy-3-oxopropyl benzoate |
| Ramipril-068 | 1239450-42-0 | 2-Benzamido-3-ethoxy-3-oxopropyl benzoate |
| Ramipril-069 | 55299-57-5 | Ethyl N,O-diacetylserinate |
| Ramipril-070 | 24153-31-9 | Ethyl 2-benzamidoprop-2-enoate |
| Ramipril-060 | 38524-17-3 | Ethyl 2-(benzoylamino)acrylate |
| Ramipril-071 | - | 2-Acetamido-2-propenoic acid methyl ester |
| Ramipril-023 | - | 1-Morpholinocyclopentene |
| Ramipril-061 | - | Cyclopentanone |
| Ramipril-072 | 1802682-27-4 | Ethyl N-benzoyl-3-(2-oxocyclopentyl)alaninate |
| Ramipril-063 | 1802682-27-4 | Ethyl N-benzoyl-3-(2-oxocyclopentyl)alaninate |
| Ramipril-003 | 87269-85-0 | (Methyl 2-(acetylamino)-3-(2-oxocyclopentyl)propanoate) |
| Ramipril-073 | - | Benzyl octahydrocyclopenta[b]pyrrole-2-carboxylate hydrogen chloride |
| Ramipril-074 | - | Octahydrocyclopenta[b]pyrrole-2-carboxylic acid hydrogen chloride |
ProcessRoute 1Steps 7 · Total yield 18.5kg(Ramipril (Free))
Ramipril-001—Ramipril-00287333-22-0Ramipril-00387269-85-0Ramipril-00487269-86-1Ramipril-005—Ramipril-006—Ramipril-00787269-88-3Ramipril-00887269-87-2Ramipril-009—API · Atorvastatin Calcium Hydrate/Ramipril
| Code | CAS No. | Intermediate |
|---|---|---|
| Ramipril-001 | - | 1-(1-Cyclopentenyl)pyrrolidine |
| Ramipril-002 | 87333-22-0 | (+/-)-Methyl 2-(Acetylamino)-3-chloropropionate |
| Ramipril-003 | 87269-85-0 | (Methyl 2-(acetylamino)-3-(2-oxocyclopentyl)propanoate) |
| Ramipril-004 | 87269-86-1 | (2S,3aS,6aS)-Octahydrocyclopenta[b]pyrrole-2-carboxylic acid hydrochloride |
| Ramipril-005 | - | Benzyl (2S,3aR,6aS)-octahydrocyclopenta[b]pyrrole-2-carboxylic acid hydrochloride |
| Ramipril-006 | - | N-[(S)-(+)-1-(Ethoxycarbonyl)-3-phenylpropyl]-L-alanine |
| Ramipril-007 | 87269-88-3 | (2S,3aS,6aS)-1-[N-[1(S)-(Ethoxycarbonyl)-3-phenylpropyl]-L-alanyl]perhydrocyclopenta[b]pyrrole-2-carboxylic acid |
| Ramipril-008 | 87269-87-2 | Benzyl (2S,3aS,6aS)-octahydrocyclopenta[b]pyrrole-2-carboxylate hydrochloride |
| Ramipril-009 | - | Benzyl (2S,3aS,6aS)-octahydrocyclopenta[b]pyrrole-2-carboxylate sulfate |
ProcessRoute 14Steps 3 · Total yield /
Ramipril-075—Ramipril-076—Ramipril-077—Ramipril-078—API · Atorvastatin Calcium Hydrate/Ramipril
| Code | CAS No. | Intermediate |
|---|---|---|
| Ramipril-075 | - | (S)-2-Amino-3-hydroxypropanoic acid |
| Ramipril-076 | - | L-Serine methyl ester hydrochloride |
| Ramipril-077 | - | Methyl 3-chloro-L-alaninate hydrogen chloride |
| Ramipril-078 | - | Methyl N-acetyl-3-chloro-D-alaninate |
ProcessRoute 15Steps 3 · Total yield 723.11g(Ramipril (Free))
Ramipril-006—Ramipril-079108430-65-5Ramipril-00487269-86-1Ramipril-0802738483-63-9API · Atorvastatin Calcium Hydrate/Ramipril
| Code | CAS No. | Intermediate |
|---|---|---|
| Ramipril-006 | - | N-[(S)-(+)-1-(Ethoxycarbonyl)-3-phenylpropyl]-L-alanine |
| Ramipril-079 | 108430-65-5 | N-(tert-Butoxycarbonyl)-N-[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]-L-alanine |
| Ramipril-004 | 87269-86-1 | (2S,3aS,6aS)-Octahydrocyclopenta[b]pyrrole-2-carboxylic acid hydrochloride |
| Ramipril-080 | 2738483-63-9 | (2S,3aS,6aS)-1-[(2S)-2-[(tert-Butoxycarbonyl)[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoyl]octahydrocyclopenta[b]pyrrole-2-carboxylic acid |
Frequently asked questions
What are the approved indications of Atorvastatin Calcium Hydrate/Ramipril?
Approved indications include: Hypercholesterolaemia, Hypertension.
When does the Atorvastatin Calcium Hydrate/Ramipril patent expire?
No public expiry year is available for Atorvastatin Calcium Hydrate/Ramipril yet; this page updates once verified.
How many synthesis routes are recorded for Atorvastatin Calcium Hydrate/Ramipril?
20 synthesis routes are recorded; the shortest is 1 steps with / total yield. Intermediates in each route carry codes and CAS numbers.
Where can I buy Atorvastatin Calcium Hydrate/Ramipril intermediates?
4 intermediate CAS of Atorvastatin Calcium Hydrate/Ramipril are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.
How do I get a quote for Atorvastatin Calcium Hydrate/Ramipril intermediates?
Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.
Source: cross-verified data (structured fields only) · 2026-09-29