Belotecan Hydrochloride

Tier C — Watch / trade

Chong Kun Dang Pharmaceutical Corp

Originator

2003

First approval

Expiry (public)

No sales data

Peak sales

Small molecule

Type

Targets：TOP1

Brand：Camtobell

Indications (approved)：Non-small cell lung cancer, Ovarian cancer

Regional status

No progress

2003-09-01

China

Japan

Synthetic routes & intermediates4 routes

Originator routes × 1Optimised (non-patent) × 3Process routes × 0

Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.

OriginatorRoute 1Steps 4 · Total yield /

BELOH-001577-59-3BELOH-00275-31-0BELOH-003177611-35-7BELOH-004177611-40-4BELOH-005110351-94-5BELOH-006—API · Belotecan Hydrochloride

Code	CAS No.	Intermediate
BELOH-001	577-59-3	1-(2-nitrophenyl)ethan-1-one
BELOH-002	75-31-0 Available	propan-2-amine
BELOH-003	177611-35-7	benzyl isopropyl(3-(2-nitrophenyl)-3-oxopropyl)carbamate
BELOH-004	177611-40-4	benzyl (3-(2-aminophenyl)-3-oxopropyl)(isopropyl)carbamate
BELOH-005	110351-94-5	(S)-4-ethyl-4-hydroxy-7,8-dihydro-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione
BELOH-006	-	benzyl (S)-(2-(4-ethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-11-yl)ethyl)(isopropyl)carbamate

OptimisedRoute 2Steps 10 · Total yield /

BELOH-005110351-94-5BELOH-007127318-97-2BELOH-008165674-30-6BELOH-009165674-31-7BELOH-0101369536-41-3BELOH-011—BELOH-012—BELOH-013—BELOH-014165674-36-2BELOH-015110351-93-4BELOH-01626908-34-9BELOH-0177689-03-4API · Belotecan Hydrochloride

Code	CAS No.	Intermediate
BELOH-005	110351-94-5	(S)-4-ethyl-4-hydroxy-7,8-dihydro-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione
BELOH-007	127318-97-2	4-ethyl-1,4,7,8-tetrahydro-3H,10H-spiro[pyrano[3,4-f]indolizine-6,2'-[1,3]dioxolane]-3,10-dione
BELOH-008	165674-30-6	4-ethyl-3-hydroxy-3,4,7,8-tetrahydro-1H,10H-spiro[pyrano[3,4-f]indolizine-6,2'-[1,3]dioxolan]-10-one
BELOH-009	165674-31-7	4-ethyl-7,8-dihydro-1H,10H-spiro[pyrano[3,4-f]indolizine-6,2'-[1,3]dioxolan]-10-one
BELOH-010	1369536-41-3	(4S)-4-ethyl-3,4-dihydroxy-3,4,7,8-tetrahydro-1H,10H-spiro[pyrano[3,4-f]indolizine-6,2'-[1,3]dioxolan]-10-one
BELOH-011	-	(4S)-4-ethyl-4-hydroxy-10-oxo-4,7,8,10-tetrahydro-1H,3H-spiro[pyrano[3,4-f]indolizine-6,2'-[1,3]dioxolan]-3-yl acetate
BELOH-012	-	(4S)-4-ethyl-4-(methoxymethoxy)-10-oxo-4,7,8,10-tetrahydro-1H,3H-spiro[pyrano[3,4-f]indolizine-6,2'-[1,3]dioxolan]-3-yl acetate
BELOH-013	-	(4S)-4-ethyl-3-hydroxy-4-(methoxymethoxy)-3,4,7,8-tetrahydro-1H,10H-spiro[pyrano[3,4-f]indolizine-6,2'-[1,3]dioxolan]-10-one
BELOH-014	165674-36-2	(S)-4-ethyl-4-(methoxymethoxy)-1,4,7,8-tetrahydro-3H,10H-spiro[pyrano[3,4-f]indolizine-6,2'-[1,3]dioxolane]-3,10-dione
BELOH-015	110351-93-4	(S)-4-ethyl-4-hydroxy-1,4,7,8-tetrahydro-3H,10H-spiro[pyrano[3,4-f]indolizine-6,2'-[1,3]dioxolane]-3,10-dione
BELOH-016	26908-34-9	2-(1,3-dioxolan-2-yl)aniline
BELOH-017	7689-03-4	(S)-4-ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione

OptimisedRoute 3Steps 2 · Total yield 12.1 g

BELOH-0177689-03-4BELOH-01878287-26-0API · Belotecan Hydrochloride

Code	CAS No.	Intermediate
BELOH-017	7689-03-4	(S)-4-ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
BELOH-018	78287-26-0	(S)-4-ethyl-4-hydroxy-11-methyl-1,12-dihydro-14H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H)-dione

OptimisedRoute 4Steps 2 · Total yield /

BELOH-0177689-03-4BELOH-01878287-26-0BELOH-019108-62-3BELOH-020110-88-3API · Belotecan Hydrochloride

Code	CAS No.	Intermediate
BELOH-017	7689-03-4	(S)-4-ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
BELOH-018	78287-26-0	(S)-4-ethyl-4-hydroxy-11-methyl-1,12-dihydro-14H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H)-dione
BELOH-019	108-62-3	2,4,6,8-tetramethyl-1,3,5,7-tetraoxocane
BELOH-020	110-88-3	1,3,5-trioxane

Frequently asked questions

What are the approved indications of Belotecan Hydrochloride?

Approved indications include: Non-small cell lung cancer, Ovarian cancer.

When does the Belotecan Hydrochloride patent expire?

No public expiry year is available for Belotecan Hydrochloride yet; this page updates once verified.

How many synthesis routes are recorded for Belotecan Hydrochloride?

4 synthesis routes are recorded; the shortest is 2 steps with 12.1 g total yield. Intermediates in each route carry codes and CAS numbers.

Where can I buy Belotecan Hydrochloride intermediates?

1 intermediate CAS of Belotecan Hydrochloride are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.

How do I get a quote for Belotecan Hydrochloride intermediates?

Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.

Source: cross-verified data (structured fields only) · 2026-09-29