Alvelestat
Tier C — Watch / tradeAlvelestat
Targets：ELANE
Indications (approved)：COVID-19, α1抗胰蛋白酶缺乏症, Emphysema, Chronic obstructive pulmonary disease, 闭塞性细支气管炎, Graft-versus-host disease, Type 2 diabetes, Insulin resistance
Regional status
Synthetic routes & intermediates1 routes
Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.
| Code | CAS No. | Intermediate |
|---|---|---|
| ALVEL-001 | 98-16-8 | 3-(trifluoromethyl)aniline |
| ALVEL-002 | - | ethyl 3-chloro-3-oxopropanoate |
| ALVEL-003 | 15386-86-4 | ethyl 3-oxo-3-[3-(trifluoromethyl)anilino]propanoate |
| ALVEL-004 | 4652-27-1 | ethyl 3-oxo-3-((3-(trifluoromethyl)phenyl)amino)propanoate |
| ALVEL-005 | 694479-56-6 | (E)-4-methoxybut-3-en-2-one |
| ALVEL-006 | 950857-36-0 | 6-methyl-2-oxo-1-(3-(trifluoromethyl)phenyl)-1,2-dihydropyridine-3-carboxylic acid |
| ALVEL-007 | 847818-74-0 | 1-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole |
| ALVEL-008 | 848141-07-1 | 6-methyl-5-(1-methyl-1H-pyrazol-5-yl)-2-oxo-1-(3-(trifluoromethyl)phenyl)-1,2-dihydropyridine-3-carboxylic acid |
| ALVEL-009 | 848141-14-0 | 6-methyl-5-(1-methyl-1H-pyrazol-5-yl)-2-oxo-1-(3-(trifluoromethyl)phenyl)-1,2-dihydropyridine-3-carboxylic acid |
| ALVEL-010 | 97483-77-7 | (5-(methylsulfonyl)pyridin-2-yl)methanamine hydrochloride |
| ALVEL-011 | 848141-13-9 | 5-bromopicolinonitrile |
| Alvelestat | 848141-11-7 | 5-(methylsulfonyl)picolinonitrile |
Frequently asked questions
What are the approved indications of Alvelestat?
Approved indications include: COVID-19, α1抗胰蛋白酶缺乏症, Emphysema, Chronic obstructive pulmonary disease, 闭塞性细支气管炎, Graft-versus-host disease, Type 2 diabetes, Insulin resistance.
When does the Alvelestat patent expire?
No public expiry year is available for Alvelestat yet; this page updates once verified.
How many synthesis routes are recorded for Alvelestat?
1 synthesis routes are recorded; the shortest is 7 steps with 96 kg total yield. Intermediates in each route carry codes and CAS numbers.
Where can I buy Alvelestat intermediates?
All intermediates in Alvelestat routes have CAS profiles — you can submit an RFQ per CAS and it enters the Unibest matching pool.
How do I get a quote for Alvelestat intermediates?
Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.
Source: cross-verified data (structured fields only) · 2026-10-22