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Sofosbuvir

Tier B — Position early

Sofosbuvir

Gilead Inc
Originator
2013
First approval
-
Expiry (public)
$10.28B ▲
Peak sales
Small molecule
Type

Targets：NS5B

Brand：Sovaldi, Elbanovir, Resof

Indications (approved)：Chronic hepatitis C, Hepatitis C

Regional status

US
Approved
2013-12-06
EU
Approved
2014-01-16
China
Approved
2017-09-20
Japan
Approved
2015-03-26

Synthetic routes & intermediates3 routes

Originator routes × 1Optimised (non-patent) × 2Process routes × 0

Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.

OriginatorRoute 2Steps 6 · Total yield 57 mg
SOFO-004863329-66-2SOFO-00862062-65-1SOFO-0091160557-97-0SOFO-01040608-06-8SOFO-0111256490-32-0SOFO-0121256490-53-5SOFO-0131256490-49-9SOFO-0141256490-33-1SOFO-015108-95-2SOFO-016777-52-6API · Sofosbuvir
CodeCAS No.Intermediate
SOFO-004863329-66-2Available1-((2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)-3-methyltetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione
SOFO-00862062-65-1Available(S)-isopropyl 2-aminopropanoate hydrochloride
SOFO-0091160557-97-0Available1-((2R,3R,4R,5R)-5-(((tert-butyldimethylsilyl)oxy)methyl)-3-fluoro-4-hydroxy-3-methyltetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione
SOFO-01040608-06-8Available4-oxopentanoic anhydride
SOFO-0111256490-32-0Available(2R,3R,4R,5R)-2-(((tert-butyldimethylsilyl)oxy)methyl)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-4-methyltetrahydrofuran-3-yl 4-oxopentanoate
SOFO-0121256490-53-5Available(2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-2-(hydroxymethyl)-4-methyltetrahydrofuran-3-yl 4-oxopentanoate
SOFO-0131256490-49-9Available(S)-isopropyl 2-(((R)-(4-nitrophenoxy)(phenoxy)phosphoryl)amino)propanoate
SOFO-0141256490-33-1Available(2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-2-((((S)-(((S)-1-isopropoxy-1-oxopropan-2-yl)amino)(phenoxy)phosphoryl)oxy)methyl)-4-methyltetrahydrofuran-3-yl 4-oxopentanoate
SOFO-015108-95-2Availablephenol
SOFO-016777-52-6Available4-nitrophenyl phosphorodichloridate
OptimisedRoute 1Steps 6 · Total yield 10.5 g
SOFO-001817204-33-4SOFO-002817204-32-3SOFO-003863329-65-1SOFO-004863329-66-2SOFO-005261909-49-3SOFO-0061190307-88-0SOFO-007770-12-7SOFO-00862062-65-1API · Sofosbuvir
CodeCAS No.Intermediate
SOFO-001817204-33-4Available4-amino-1-((2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)-3-methyltetrahydrofuran-2-yl)pyrimidin-2(1H)-one
SOFO-002817204-32-3Available(2R,3R,4R,5R)-5-(4-benzamido-2-oxopyrimidin-1(2H)-yl)-2-((benzoyloxy)methyl)-4-fluoro-4-methyltetrahydrofuran-3-yl benzoate
SOFO-003863329-65-1Available((2R,3R,4R,5R)-3-(benzoyloxy)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-4-methyltetrahydrofuran-2-yl)methyl benzoate
SOFO-004863329-66-2Available1-((2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)-3-methyltetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione
SOFO-005261909-49-3Available(2S)-isopropyl 2-((chloro(phenoxy)phosphoryl)amino)propanoate
SOFO-0061190307-88-0Available(2S)-isopropyl 2-(((((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)amino)propanoate
SOFO-007770-12-7Availablephenyl phosphorodichloridate
SOFO-00862062-65-1Available(S)-isopropyl 2-aminopropanoate hydrochloride
OptimisedRoute 3Steps 11 · Total yield 6.9 g
SOFO-002817204-32-3SOFO-003863329-65-1SOFO-004863329-66-2SOFO-007770-12-7SOFO-00862062-65-1SOFO-01715186-48-8SOFO-0185717-37-3SOFO-01981997-76-4SOFO-02093635-76-8SOFO-0211033394-83-0SOFO-022879551-04-9SOFO-023874638-80-9SOFO-0241199809-23-8SOFO-02526661-13-2SOFO-0261334513-02-8API · Sofosbuvir
CodeCAS No.Intermediate
SOFO-002817204-32-3Available(2R,3R,4R,5R)-5-(4-benzamido-2-oxopyrimidin-1(2H)-yl)-2-((benzoyloxy)methyl)-4-fluoro-4-methyltetrahydrofuran-3-yl benzoate
SOFO-003863329-65-1Available((2R,3R,4R,5R)-3-(benzoyloxy)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-4-methyltetrahydrofuran-2-yl)methyl benzoate
SOFO-004863329-66-2Available1-((2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)-3-methyltetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione
SOFO-007770-12-7Availablephenyl phosphorodichloridate
SOFO-00862062-65-1Available(S)-isopropyl 2-aminopropanoate hydrochloride
SOFO-01715186-48-8Available(R)-2,2-dimethyl-1,3-dioxolane-4-carbaldehyde
SOFO-0185717-37-3Availableethyl 2-(triphenylphosphoranylidene)propanoate
SOFO-01981997-76-4Available(S,E)-ethyl 3-(2,2-dimethyl-1,3-dioxolan-4-yl)-2-methylacrylate
SOFO-02093635-76-8Available(2S,3R)-ethyl 3-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-2,3-dihydroxy-2-methylpropanoate
SOFO-0211033394-83-0Available(2R,3R)-ethyl 3-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-2-fluoro-3-hydroxy-2-methylpropanoate
SOFO-022879551-04-9Available(3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)-3-methyldihydrofuran-2(3H)-one
SOFO-023874638-80-9Available((2R,3R,4R)-3-(benzoyloxy)-4-fluoro-4-methyl-5-oxotetrahydrofuran-2-yl)methyl benzoate
SOFO-0241199809-23-8Available((2R,3R,4R)-3-(benzoyloxy)-5-chloro-4-fluoro-4-methyltetrahydrofuran-2-yl)methyl benzoate
SOFO-02526661-13-2AvailableN-(2-oxo-1,2-dihydropyrimidin-4-yl)benzamide
SOFO-0261334513-02-8Available(S)-isopropyl 2-(((S)-(perfluorophenoxy)(phenoxy)phosphoryl)amino)propanoate

Frequently asked questions

What are the approved indications of Sofosbuvir?

Approved indications include: Chronic hepatitis C, Hepatitis C.

When does the Sofosbuvir patent expire?

No public expiry year is available for Sofosbuvir yet; this page updates once verified.

How many synthesis routes are recorded for Sofosbuvir?

3 synthesis routes are recorded; the shortest is 6 steps with 10.5 g total yield. Intermediates in each route carry codes and CAS numbers.

Where can I buy Sofosbuvir intermediates?

26 intermediate CAS of Sofosbuvir are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.

How do I get a quote for Sofosbuvir intermediates?

Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.

Source: cross-verified data (structured fields only) · 2026-09-29