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Ibuprofen/Phenylephrine Hydrochloride
Tier C — Watch / tradeIbuprofen/Phenylephrine Hydrochloride
Pfizer Inc.
Originator
2010
First approval
-
Expiry (public)
No sales data
Peak sales
Small molecule
Type
Targets：ADRA1, COXs
Brand：Advil Congestion Relief
Indications (approved)：Common cold
Regional status
US
Approved
2010-05-27
EU
-
China
Phase III
2024-03-01
Japan
-
Factories producing this API10
Factories registered as producing this API in our sourcing network (RFQ records + product master), sorted by RFQ activity; the snapshot carries no cost or customer data.
10 producing factories on file — sign in to view the named list (factory details are not shown to guests).
Sign in to view factories →Synthetic routes & intermediates11 routes
Originator routes × 0Optimised (non-patent) × 10Process routes × 1
Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.
OptimisedRoute 1Steps 1 · Total yield /
IBUP-00136039-36-8Ibuprofen15687-27-1API · Ibuprofen/Phenylephrine Hydrochloride
| Code | CAS No. | Intermediate |
|---|---|---|
| IBUP-001 | 36039-36-8 | 2-(4-isobutylphenyl)propan-1-ol |
| Ibuprofen | 15687-27-1 | 2-(4-isobutylphenyl)propanoic acid |
OptimisedRoute 2Steps 4 · Total yield /
IBUP-00238861-78-8IBUP-00334352-86-8IBUP-0041424343-26-9IBUP-00551407-46-6API · Ibuprofen/Phenylephrine Hydrochloride
| Code | CAS No. | Intermediate |
|---|---|---|
| IBUP-002 | 38861-78-8 | 1-(4-isobutylphenyl)ethan-1-one |
| IBUP-003 | 34352-86-8 | 1-isobutyl-4-(prop-1-en-2-yl)benzene |
| IBUP-004 | 1424343-26-9 | 2-(4-isobutylphenyl)prop-2-en-1-ol |
| IBUP-005 | 51407-46-6 | 2-(4-isobutylphenyl)propanal |
OptimisedRoute 3Steps 1 · Total yield 19.1 g (Ibuprofen)
IBUP-00680336-64-7IBUP-007126-30-7API · Ibuprofen/Phenylephrine Hydrochloride
| Code | CAS No. | Intermediate |
|---|---|---|
| IBUP-006 | 80336-64-7 | 2-bromo-1-(4-isobutylphenyl)propan-1-one |
| IBUP-007 | 126-30-7 | 2,2-dimethylpropane-1,3-diol |
OptimisedRoute 4Steps 5 · Total yield /
IBUP-008538-93-2IBUP-00940150-92-3IBUP-0101186634-35-4IBUP-01158609-73-7API · Ibuprofen/Phenylephrine Hydrochloride
| Code | CAS No. | Intermediate |
|---|---|---|
| IBUP-008 | 538-93-2 | isobutylbenzene |
| IBUP-009 | 40150-92-3 | 1-(4-isobutylphenyl)ethan-1-ol |
| IBUP-010 | 1186634-35-4 | 1-(4-isobutylphenyl)ethyl methanesulfonate |
| IBUP-011 | 58609-73-7 | 2-(4-isobutylphenyl)propanenitrile |
OptimisedRoute 1Steps 6 · Total yield /
Phenylephrine Hydrochloride-001—Phenylephrine Hydrochloride-002139461-72-6Phenylephrine Hydrochloride-0031774-47-6Phenylephrine Hydrochloride-004215439-42-2Phenylephrine Hydrochloride-005215439-44-4Phenylephrine Hydrochloride-006215439-43-3Phenylephrine Hydrochloride-007215439-45-5API · Ibuprofen/Phenylephrine Hydrochloride
| Code | CAS No. | Intermediate |
|---|---|---|
| Phenylephrine Hydrochloride-001 | - | (3-Hydroxyphenyl)formaldehyde |
| Phenylephrine Hydrochloride-002 | 139461-72-6 | 3-[(2-methoxyethoxy)methoxy]benzaldehyde |
| Phenylephrine Hydrochloride-003 | 1774-47-6 | Trimethyl sulfoxide iodide |
| Phenylephrine Hydrochloride-004 | 215439-42-2 | 2-{3-[(2-methoxyethoxy)methoxy]phenyl}oxirane |
| Phenylephrine Hydrochloride-005 | 215439-44-4 | (1S)-1-{3-[(2-methoxyethoxy)methoxy]phenyl}ethane-1,2-diol |
| Phenylephrine Hydrochloride-006 | 215439-43-3 | (2R)-2-{3-[(2-methoxyethoxy)methoxy]phenyl}oxirane |
| Phenylephrine Hydrochloride-007 | 215439-45-5 | (1R)-1-{3-[(2-methoxyethoxy)methoxy]phenyl}-2-(methylamino)ethanol |
OptimisedRoute 2Steps 9 · Total yield /
Phenylephrine Hydrochloride-001—Phenylephrine Hydrochloride-01096013-95-5Phenylephrine Hydrochloride-0113487-44-3Phenylephrine Hydrochloride-012—Phenylephrine Hydrochloride-013—Phenylephrine Hydrochloride-014603983-65-9Phenylephrine Hydrochloride-015603983-66-0Phenylephrine Hydrochloride-016603983-67-1Phenylephrine Hydrochloride-017603983-68-2Phenylephrine Hydrochloride-018—Phenylephrine Hydrochloride-019—API · Ibuprofen/Phenylephrine Hydrochloride
| Code | CAS No. | Intermediate |
|---|---|---|
| Phenylephrine Hydrochloride-001 | - | (3-Hydroxyphenyl)formaldehyde |
| Phenylephrine Hydrochloride-010 | 96013-95-5 | 3-(tert-Butyldimethylsilyloxy)benzaldehyde |
| Phenylephrine Hydrochloride-011 | 3487-44-3 | Methylene(triphenyl)phosphorane |
| Phenylephrine Hydrochloride-012 | - | Methyl(triphenyl)phosphonium iodide |
| Phenylephrine Hydrochloride-013 | - | tert-Butyl(dimethyl)(3-vinylphenoxy)silane |
| Phenylephrine Hydrochloride-014 | 603983-65-9 | (1R)-1-(3-[[tert-Butyl(dimethyl)silyl]oxy]phenyl)ethane-1,2-diol |
| Phenylephrine Hydrochloride-015 | 603983-66-0 | (2R)-2-(3-[[tert-Butyl(dimethyl)silyl]oxy]phenyl)-2-hydroxyethyl 4-methylbenzenesulfonate |
| Phenylephrine Hydrochloride-016 | 603983-67-1 | (2R)-2-Hydroxy-2-(3-hydroxyphenyl)ethyl 4-methylbenzenesulfonate |
| Phenylephrine Hydrochloride-017 | 603983-68-2 | 3-[(1R)-1-Hydroxy-2-iodoethyl]phenol |
| Phenylephrine Hydrochloride-018 | - | Aminomethane |
| Phenylephrine Hydrochloride-019 | - | 3-[(1R)-1-Hydroxy-2-(methylamino)ethyl]phenol |
OptimisedRoute 3Steps 9 · Total yield 146.9g(Phenylephrine Hydrochloride (API))
Phenylephrine Hydrochloride-020614-03-9Phenylephrine Hydrochloride-0211515872-98-6Phenylephrine Hydrochloride-022—Phenylephrine Hydrochloride-0231515873-00-3Phenylephrine Hydrochloride-024—Phenylephrine Hydrochloride-025—Phenylephrine Hydrochloride-019—Phenylephrine Hydrochloride-026—API · Ibuprofen/Phenylephrine Hydrochloride
| Code | CAS No. | Intermediate |
|---|---|---|
| Phenylephrine Hydrochloride-020 | 614-03-9 | 3-[(1S)-1-Hydroxy-2-(methylamino)ethyl]phenol |
| Phenylephrine Hydrochloride-021 | 1515872-98-6 | 3-[(1S)-1-Hydroxy-2-(methylamino)ethyl]phenyl benzoate |
| Phenylephrine Hydrochloride-022 | - | 3-[(1S)-2-[Acetyl(methyl)amino]-1-hydroxyethyl]phenyl benzoate |
| Phenylephrine Hydrochloride-023 | 1515873-00-3 | 3-(N-Acetyl-N-methylglycyl)phenyl benzoate |
| Phenylephrine Hydrochloride-024 | - | 1-(3-Hydroxyphenyl)-2-(methylamino)ethanone sulfate |
| Phenylephrine Hydrochloride-025 | - | 3-[1-Hydroxy-2-(methylamino)ethyl]phenol |
| Phenylephrine Hydrochloride-019 | - | 3-[(1R)-1-Hydroxy-2-(methylamino)ethyl]phenol |
| Phenylephrine Hydrochloride-026 | - | (1R)-1-(3-Hydroxyphenyl)-2-(methylamino)ethyl acetate sulfate |
OptimisedRoute 4Steps 3 · Total yield 5.3g(Phenylephrine Hydrochloride-031)
Phenylephrine Hydrochloride-027—Phenylephrine Hydrochloride-02838396-89-3Phenylephrine Hydrochloride-029—Phenylephrine Hydrochloride-030—Phenylephrine Hydrochloride-031—API · Ibuprofen/Phenylephrine Hydrochloride
| Code | CAS No. | Intermediate |
|---|---|---|
| Phenylephrine Hydrochloride-027 | - | 3-Acetoxy acetophenone |
| Phenylephrine Hydrochloride-028 | 38396-89-3 | 3-(Bromoacetyl)phenyl acetate |
| Phenylephrine Hydrochloride-029 | - | Benzylmethylamine |
| Phenylephrine Hydrochloride-030 | - | 3-(N-Benzyl-N-methylglycyl)phenyl acetate |
| Phenylephrine Hydrochloride-031 | - | 1-(3-Hydroxyphenyl)-2-[methyl(phenylmethyl)amino]ethanone hydrochloride |
OptimisedRoute 6Steps 6 · Total yield 108g(Phenylephrine Hydrochloride (API))
Phenylephrine Hydrochloride-034—Phenylephrine Hydrochloride-03562932-90-5Phenylephrine Hydrochloride-029—Phenylephrine Hydrochloride-031—Phenylephrine Hydrochloride-025—Phenylephrine Hydrochloride-03613998-27-1Phenylephrine Hydrochloride-019—API · Ibuprofen/Phenylephrine Hydrochloride
| Code | CAS No. | Intermediate |
|---|---|---|
| Phenylephrine Hydrochloride-034 | - | 1-(3-Hydroxyphenyl)ethanone |
| Phenylephrine Hydrochloride-035 | 62932-90-5 | 2-Chloro-1-(3-hydroxyphenyl)ethan-1-one |
| Phenylephrine Hydrochloride-029 | - | Benzylmethylamine |
| Phenylephrine Hydrochloride-031 | - | 1-(3-Hydroxyphenyl)-2-[methyl(phenylmethyl)amino]ethanone hydrochloride |
| Phenylephrine Hydrochloride-025 | - | 3-[1-Hydroxy-2-(methylamino)ethyl]phenol |
| Phenylephrine Hydrochloride-036 | 13998-27-1 | (2R,3R)-2,3-Dihydroxybutanedioic acid 3-[(1S)-1-hydroxy-2-(methylamino)ethyl]phenol |
| Phenylephrine Hydrochloride-019 | - | 3-[(1R)-1-Hydroxy-2-(methylamino)ethyl]phenol |
OptimisedRoute 7Steps 5 · Total yield /
Phenylephrine Hydrochloride-034121-71-1Phenylephrine Hydrochloride-03562932-90-5Phenylephrine Hydrochloride-037925430-39-3Phenylephrine Hydrochloride-03874-89-5Phenylephrine Hydrochloride-03959-42-7API · Ibuprofen/Phenylephrine Hydrochloride
| Code | CAS No. | Intermediate |
|---|---|---|
| Phenylephrine Hydrochloride-034 | 121-71-1 | 3-Hydroxyacetophenone |
| Phenylephrine Hydrochloride-035 | 62932-90-5 | 2-Chloro-1-(3-hydroxyphenyl)ethanone |
| Phenylephrine Hydrochloride-037 | 925430-39-3 | 3-[(1R)-2-Chloro-1-hydroxyethyl]phenol |
| Phenylephrine Hydrochloride-038 | 74-89-5 | Methylamine |
| Phenylephrine Hydrochloride-039 | 59-42-7 | Phenylephrine |
ProcessRoute 5Steps 2 · Total yield 85.2kg(Phenylephrine Hydrochloride-034)
Phenylephrine Hydrochloride-032—Phenylephrine Hydrochloride-033—Phenylephrine Hydrochloride-034—API · Ibuprofen/Phenylephrine Hydrochloride
| Code | CAS No. | Intermediate |
|---|---|---|
| Phenylephrine Hydrochloride-032 | - | 1-(3-Nitrophenyl)ethanone |
| Phenylephrine Hydrochloride-033 | - | 1-(3-Aminophenyl)ethan-1-one |
| Phenylephrine Hydrochloride-034 | - | 1-(3-Hydroxyphenyl)ethanone |
Frequently asked questions
What are the approved indications of Ibuprofen/Phenylephrine Hydrochloride?
Approved indications include: Common cold.
When does the Ibuprofen/Phenylephrine Hydrochloride patent expire?
No public expiry year is available for Ibuprofen/Phenylephrine Hydrochloride yet; this page updates once verified.
How many synthesis routes are recorded for Ibuprofen/Phenylephrine Hydrochloride?
11 synthesis routes are recorded; the shortest is 1 steps with / total yield. Intermediates in each route carry codes and CAS numbers.
Where can I buy Ibuprofen/Phenylephrine Hydrochloride intermediates?
All intermediates in Ibuprofen/Phenylephrine Hydrochloride routes have CAS profiles — you can submit an RFQ per CAS and it enters the Unibest matching pool.
How do I get a quote for Ibuprofen/Phenylephrine Hydrochloride intermediates?
Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.
Source: cross-verified data (structured fields only) · 2026-09-29