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Amlodipine Orotate
Tier C — Watch / tradeAmlodipine Orotate
Dong-A ST Co Ltd
Originator
2005
First approval
-
Expiry (public)
No sales data
Peak sales
Small molecule
Type
Targets：VDCCs
Indications (approved)：Variant angina, Hypertension, Ischaemic heart disease, Stable angina
Regional status
US
-
EU
-
China
-
Japan
-
Synthetic routes & intermediates11 routes
Originator routes × 0Optimised (non-patent) × 11Process routes × 0
Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.
OptimisedRoute 1Steps 3 · Total yield /
(I)109067-1-a638-07-3(II)109067-1-a1517-05-1(III)109067-1-a88150-45-2(IV)109067-1-a14205-39-1(V)109067-1-a89-98-5(VI)109067-1-a88150-46-3API · Amlodipine Orotate
| Code | CAS No. | Intermediate |
|---|---|---|
| (I)109067-1-a | 638-07-3 | Ethyl 4-chloro-3-oxobutanoate |
| (II)109067-1-a | 1517-05-1 | 2-azidoethan-1-ol |
| (III)109067-1-a | 88150-45-2 | ethyl 4-(2-azidoethoxy)-3-oxobutanoate |
| (IV)109067-1-a | 14205-39-1 | 3-Amino-2-butenoic acid methyl ester |
| (V)109067-1-a | 89-98-5 | 2-Chlorobenzaldehyde |
| (VI)109067-1-a | 88150-46-3 | 3-ethyl 5-methyl 2-[(2-azidoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate |
OptimisedRoute 2Steps 4 · Total yield /
(I)109067-2-a638-07-3(II)109067-2-a2222844-70-2(III)109067-2-a3891-07-4(IV)109067-2-a88150-75-8(V)109067-2-a—(VI)109067-2-a1170036-31-3(VII)109067-2-a103094-30-0,88150-62-3API · Amlodipine Orotate
| Code | CAS No. | Intermediate |
|---|---|---|
| (I)109067-2-a | 638-07-3 | Ethyl 4-chloro-3-oxobutanoate |
| (II)109067-2-a | 2222844-70-2 | Ethyl 4-[(4-methylbenzene-1-sulfonyl)oxy]-3-oxobutanoate |
| (III)109067-2-a | 3891-07-4 | N-(2-Hydroxyethyl)phthalimide |
| (IV)109067-2-a | 88150-75-8 | Ethyl 4-(2-phthalimidoethoxy)acetoacetate |
| (V)109067-2-a | - | Ethyl (2Z)-3-amino-4-[2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)ethoxy]but-2-enoate |
| (VI)109067-2-a | 1170036-31-3 | Methyl (2Z)-2-[(2-chlorophenyl)methylidene]-3-oxobutanoate |
| (VII)109067-2-a | 103094-30-0,88150-62-3 | 3-Ethyl 5-methyl (4RS)-4-(2-chlorophenyl)-2-[[2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)ethoxy]methyl]-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate |
OptimisedRoute 3Steps 3 · Total yield /
(I)109067-3-a638-07-3(II)109067-3-a1517-05-1(III)109067-3-a88150-45-2(IV)109067-3-a1170036-31-3(V)109067-3-a88150-46-3API · Amlodipine Orotate
| Code | CAS No. | Intermediate |
|---|---|---|
| (I)109067-3-a | 638-07-3 | 4-Chloro-3-oxobutyric acid ethyl ester |
| (II)109067-3-a | 1517-05-1 | 2-azidoethan-1-ol |
| (III)109067-3-a | 88150-45-2 | ethyl 4-(2-azidoethoxy)-3-oxobutanoate |
| (IV)109067-3-a | 1170036-31-3 | Methyl (2Z)-2-[(2-chlorophenyl)methylidene]-3-oxobutanoate |
| (V)109067-3-a | 88150-46-3 | 3-ethyl 5-methyl 2-[(2-azidoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate |
OptimisedRoute 4Steps 6 · Total yield /
(I)109067-4-a6065-82-3(II)109067-4-a621-63-6(III)109067-4-a638-07-3(IV)109067-4-a225939-10-6(V)109067-4-a89-98-5(VI)109067-4-a—(VII)109067-4-a14205-39-1(VIII)109067-4-a194472-23-6(IX)109067-4-a—(X)109067-4-a—(XI)109067-4-a1170036-31-3API · Amlodipine Orotate
| Code | CAS No. | Intermediate |
|---|---|---|
| (I)109067-4-a | 6065-82-3 | Diethoxyacetic acid ethyl ester |
| (II)109067-4-a | 621-63-6 | 2,2-Diethoxyethanol |
| (III)109067-4-a | 638-07-3 | 4-Chloro-3-oxobutyric acid ethyl ester |
| (IV)109067-4-a | 225939-10-6 | ethyl 4-(2,2-diethoxyethoxy)-3-oxobutanoate |
| (V)109067-4-a | 89-98-5 | 2-Chlorobenzaldehyde |
| (VI)109067-4-a | - | ethyl (2Z)-2-[(2-chlorophenyl)methylidene]-4-(2,2-dimethoxyethoxy)-3-oxobutanoate |
| (VII)109067-4-a | 14205-39-1 | Methyl 3-amino-2-butenoate |
| (VIII)109067-4-a | 194472-23-6 | 3-ethyl 5-methyl 4-(2-chlorophenyl)-2-[(2,2-dimethoxyethoxy)methyl]-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate |
| (IX)109067-4-a | - | 3-ethyl 5-methyl 4-(2-chlorophenyl)-2-{[(2E)-2-(hydroxyimino)ethoxy]methyl}-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate |
| (X)109067-4-a | - | ethyl (2E)-3-amino-4-(2,2-diethoxyethoxy)but-2-enoate |
| (XI)109067-4-a | 1170036-31-3 | Methyl (2Z)-2-[(2-chlorophenyl)methylidene]-3-oxobutanoate |
OptimisedRoute 5Steps 4 · Total yield /
(I)109067-5-a141-43-5(II)109067-5-a33885-01-7(III)109067-5-a24070-16-4(IV)109067-5-a638-07-3(V)109067-5-a156366-26-6(VI)109067-5-a89-98-5(VII)109067-5-a14205-39-1(VIII)109067-5-a156366-27-7API · Amlodipine Orotate
| Code | CAS No. | Intermediate |
|---|---|---|
| (I)109067-5-a | 141-43-5Available | 2-Aminoethanol |
| (II)109067-5-a | 33885-01-7 | (2-chloro-1,1-diphenylethyl)benzene |
| (III)109067-5-a | 24070-16-4 | 2-[(triphenylmethyl)amino]ethan-1-ol |
| (IV)109067-5-a | 638-07-3 | Ethyl 4-chloroacetoacetate |
| (V)109067-5-a | 156366-26-6 | ethyl 3-oxo-4-{2-[(triphenylmethyl)amino]ethoxy}butanoate |
| (VI)109067-5-a | 89-98-5 | 2-Chlorobenzaldehyde |
| (VII)109067-5-a | 14205-39-1 | 3-Amino-2-butenoic acid methyl ester |
| (VIII)109067-5-a | 156366-27-7 | 3-ethyl 5-methyl 4-(2-chlorophenyl)-6-methyl-2-({2-[(triphenylmethyl)amino]ethoxy}methyl)-1,4-dihydropyridine-3,5-dicarboxylate |
OptimisedRoute 6Steps 8 · Total yield /
(I)109067-6-a1517-05-1(II)109067-6-a79-11-8(III)109067-6-a79598-48-4(IV)109067-6-a2033-24-1(V)109067-6-a109-78-4(VI)109067-6-a103069-47-2(VII)109067-6-a89-98-5(VIII)109067-6-a14205-39-1(IX)109067-6-a134471-46-8(X)109067-6-a134471-71-9(XI)109067-6-a66051-01-2(XII)109067-6-a—(XIII)109067-6-a103094-34-4(XIV)109067-6-a125711-60-6(XV)109067-6-a103129-82-4API · Amlodipine Orotate
| Code | CAS No. | Intermediate |
|---|---|---|
| (I)109067-6-a | 1517-05-1 | 2-azidoethan-1-ol |
| (II)109067-6-a | 79-11-8 | 2-Chloroacetic acid |
| (III)109067-6-a | 79598-48-4 | 2-(2-azidoethoxy)acetic acid |
| (IV)109067-6-a | 2033-24-1 | 2,2-Dimethyl-1,3-dioxane-4,6-dione |
| (V)109067-6-a | 109-78-4Available | 3-Hydroxypropionitrile |
| (VI)109067-6-a | 103069-47-2 | 2-cyanoethyl 4-(2-azidoethoxy)-3-oxobutanoate |
| (VII)109067-6-a | 89-98-5 | 2-Chlorobenzaldehyde |
| (VIII)109067-6-a | 14205-39-1 | 3-Amino-2-butenoic acid methyl ester |
| (IX)109067-6-a | 134471-46-8 | 3-(2-cyanoethyl) 5-methyl 2-[(2-azidoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate |
| (X)109067-6-a | 134471-71-9 | 2-[(2-azidoethoxy)methyl]-4-(2-chlorophenyl)-5-(methoxycarbonyl)-6-methyl-1,4-dihydropyridine-3-carboxylic acid |
| (XI)109067-6-a | 66051-01-2 | (2S)-2-methoxy-2-phenylethan-1-ol |
| (XII)109067-6-a | - | 3-(2S)-2-methoxy-2-phenylethyl 5-methyl 2-[(2-azidoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate |
| (XIII)109067-6-a | 103094-34-4 | 3-[(2S)-2-Methoxy-2-phenylethyl] 5-methyl (4S)-2-[(2-azidoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate |
| (XIV)109067-6-a | 125711-60-6 | 3-Ethyl 5-methyl (4S)-2-[(2-azidoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate |
| (XV)109067-6-a | 103129-82-4 | 3-Ethyl 5-methyl (4S)-2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate |
OptimisedRoute 7Steps 6 · Total yield /
(I)109067-8-a—(II)109067-8-a,(II)109067-8-b638-07-3(III)109067-8-a194472-29-2(IV)109067-8-a,(IV)109067-8-b89-98-5(V)109067-8-a,(V)109067-8-b14205-39-1(VI)109067-8-a194472-10-1(VII)109067-8-a194472-12-3(VIII)109067-8-a,(VIII)109067-8-b194472-14-5(IX)109067-8-a,(IX)109067-8-b—API · Amlodipine Orotate
| Code | CAS No. | Intermediate |
|---|---|---|
| (I)109067-8-a | - | [5-(hydroxymethyl)-2,2-dimethyl-1,3-dioxolan-4-yl]methanol |
| (II)109067-8-a,(II)109067-8-b | 638-07-3 | 4-Chloro-3-oxobutyric acid ethyl ester |
| (III)109067-8-a | 194472-29-2 | ethyl 4-({5-[(4-ethoxy-2,4-dioxobutoxy)methyl]-2,2-dimethyl-1,3-dioxolan-4-yl}methoxy)-3-oxobutanoate |
| (IV)109067-8-a,(IV)109067-8-b | 89-98-5 | 2-Chlorobenzaldehyde |
| (V)109067-8-a,(V)109067-8-b | 14205-39-1 | 3-Amino-2-butenoic acid methyl ester |
| (VI)109067-8-a | 194472-10-1 | 3-ethyl 5-methyl 4-(2-chlorophenyl)-2-({[5-({[4-(2-chlorophenyl)-3-(ethoxycarbonyl)-5-(methoxycarbonyl)-6-methyl-1,4-dihydropyridin-2-yl]methoxy}methyl)-2,2-dimethyl-1,3-dioxolan-4-yl]methoxy}methyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate |
| (VII)109067-8-a | 194472-12-3 | 3-ethyl 5-methyl 4-(2-chlorophenyl)-2-[(4-{[4-(2-chlorophenyl)-3-(ethoxycarbonyl)-5-(methoxycarbonyl)-6-methyl-1,4-dihydropyridin-2-yl]methoxy}-2,3-dihydroxybutoxy)methyl]-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate |
| (VIII)109067-8-a,(VIII)109067-8-b | 194472-14-5 | 3-ethyl 5-methyl 4-(2-chlorophenyl)-6-methyl-2-[(2-oxoethoxy)methyl]-1,4-dihydropyridine-3,5-dicarboxylate |
| (IX)109067-8-a,(IX)109067-8-b | - | 3-ethyl 5-methyl 4-(2-chlorophenyl)-2-{[(2E)-2-(hydroxyimino)ethoxy]methyl}-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate |
OptimisedRoute 8Steps 4 · Total yield /
(II)109067-8-a,(II)109067-8-b638-07-3(IV)109067-8-a,(IV)109067-8-b89-98-5(V)109067-8-a,(V)109067-8-b14205-39-1(VIII)109067-8-a,(VIII)109067-8-b194472-14-5(IX)109067-8-a,(IX)109067-8-b—(X)109067-8-b22323-82-6(XI)109067-8-b110464-45-4(XII)109067-8-b—(XIII)109067-8-b194472-30-5API · Amlodipine Orotate
| Code | CAS No. | Intermediate |
|---|---|---|
| (II)109067-8-a,(II)109067-8-b | 638-07-3 | 4-Chloro-3-oxobutyric acid ethyl ester |
| (IV)109067-8-a,(IV)109067-8-b | 89-98-5 | 2-Chlorobenzaldehyde |
| (V)109067-8-a,(V)109067-8-b | 14205-39-1 | 3-Amino-2-butenoic acid methyl ester |
| (VIII)109067-8-a,(VIII)109067-8-b | 194472-14-5 | 3-ethyl 5-methyl 4-(2-chlorophenyl)-6-methyl-2-[(2-oxoethoxy)methyl]-1,4-dihydropyridine-3,5-dicarboxylate |
| (IX)109067-8-a,(IX)109067-8-b | - | 3-ethyl 5-methyl 4-(2-chlorophenyl)-2-{[(2E)-2-(hydroxyimino)ethoxy]methyl}-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate |
| (X)109067-8-b | 22323-82-6 | [(4S)-2,2-Dimethyl-1,3-dioxolan-4-yl]methanol |
| (XI)109067-8-b | 110464-45-4 | ethyl 4-[(2,2-dimethyl-1,3-dioxolan-4-yl)methoxy]-3-oxobutanoate |
| (XII)109067-8-b | - | 3-ethyl 5-methyl 4-(2-chlorophenyl)-2-{[(2,2-dimethyl-1,3-dioxolan-4-yl)methoxy]methyl}-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate |
| (XIII)109067-8-b | 194472-30-5 | 3-ethyl 5-methyl 4-(2-chlorophenyl)-2-[(2,3-dihydroxypropoxy)methyl]-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate |
OptimisedRoute 9Steps 5 · Total yield /
(I)109067-9-a23326-27-4(II)109067-9-a100-46-9(III)109067-9-a24405-35-4(IV)109067-9-a—(V)109067-9-a39562-06-6(VI)109067-9-a1309115-67-0(VII)109067-9-a1517-05-1(VIII)109067-9-a—API · Amlodipine Orotate
| Code | CAS No. | Intermediate |
|---|---|---|
| (I)109067-9-a | 23326-27-4 | 2-Butynoic acid methyl ester |
| (II)109067-9-a | 100-46-9Available | 1-Phenylmethylamine |
| (III)109067-9-a | 24405-35-4 | ethyl (2Z)-2-[(2-chlorophenyl)methylidene]-3-oxobutanoate |
| (IV)109067-9-a | - | 3-methyl 5-propyl 1-benzyl-4-(2-chlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate |
| (V)109067-9-a | 39562-06-6 | 3-ethyl 5-methyl 4-(2-chlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate |
| (VI)109067-9-a | 1309115-67-0 | 3-ethyl 5-methyl 2-(bromomethyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate |
| (VII)109067-9-a | 1517-05-1 | 2-azidoethan-1-ol |
| (VIII)109067-9-a | - | 3-methyl 5-propyl 6-[(2-azidoethoxy)methyl]-4-(2-chlorophenyl)-2-methyl-1,4-dihydropyridine-3,5-dicarboxylate |
OptimisedRoute 10Steps 2 · Total yield /
(I)158395-3-a2032-35-1(II)158395-3-a—(III)158395-3-a621-63-6API · Amlodipine Orotate
Frequently asked questions
What are the approved indications of Amlodipine Orotate?
Approved indications include: Variant angina, Hypertension, Ischaemic heart disease, Stable angina.
When does the Amlodipine Orotate patent expire?
No public expiry year is available for Amlodipine Orotate yet; this page updates once verified.
How many synthesis routes are recorded for Amlodipine Orotate?
11 synthesis routes are recorded; the shortest is 1 steps with / total yield. Intermediates in each route carry codes and CAS numbers.
Where can I buy Amlodipine Orotate intermediates?
4 intermediate CAS of Amlodipine Orotate are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.
How do I get a quote for Amlodipine Orotate intermediates?
Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.
Source: cross-verified data (structured fields only) · 2026-09-29