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Rosuvastatin Calcium
Tier B — Position earlyRosuvastatin Calcium
Shionogi & Co., Ltd.
Originator
2002
First approval
-
Expiry (public)
$7.05B ▲
Peak sales
Small molecule
Type
Targets：HMGCR
Brand：Crestor
Indications (approved)：Homozygous familial hypercholesterolaemia, Heterozygous familial hypercholesterolaemia, Hyperlipoproteinaemia type III, Atherosclerosis, Hyperlipoproteinaemia type II, Hypercholesterolaemia, Dyslipidaemia
Regional status
US
Approved
2003-08-12
EU
Approved
2002-11-06
China
Approved
2006-12-27
Japan
Approved
2005-01-19
Factories producing this API3
Factories registered as producing this API in our sourcing network (RFQ records + product master), sorted by RFQ activity; the snapshot carries no cost or customer data.
3 producing factories on file — sign in to view the named list (factory details are not shown to guests).
Sign in to view factories →Synthetic routes & intermediates5 routes
Originator routes × 1Optimised (non-patent) × 3Process routes × 1
Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.
OriginatorRoute 1Steps 10 · Total yield 162 mg
ROSU-001459-57-4ROSU-0027152-15-0ROSU-003122930-45-4ROSU-004—ROSU-005147118-27-2ROSU-006147118-28-3ROSU-007147118-30-7ROSU-008147118-37-4ROSU-009147118-35-2ROSU-010147118-38-5ROSU-011147118-39-6ROSU-012147118-40-9ROSU-013147098-18-8API · Rosuvastatin Calcium
| Code | CAS No. | Intermediate |
|---|---|---|
| ROSU-001 | 459-57-4 | 4-fluorobenzaldehyde |
| ROSU-002 | 7152-15-0 | ethyl 4-methyl-3-oxopentanoate |
| ROSU-003 | 122930-45-4 | (Z)-ethyl 2-(4-fluorobenzylidene)-4-methyl-3-oxopentanoate |
| ROSU-004 | - | (methyleneamino)(methylthio)methanamine |
| ROSU-005 | 147118-27-2 | ethyl 4-(4-fluorophenyl)-6-isopropyl-2-(methylthio)pyrimidine-5-carboxylate |
| ROSU-006 | 147118-28-3 | ethyl 4-(4-fluorophenyl)-6-isopropyl-2-(methylsulfonyl)pyrimidine-5-carboxylate |
| ROSU-007 | 147118-30-7 | ethyl 4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidine-5-carboxylate |
| ROSU-008 | 147118-37-4 | N-(4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl)-N-methylmethanesulfonamide |
| ROSU-009 | 147118-35-2 | methyl (R)-3-((tert-butyldimethylsilyl)oxy)-5-oxo-6-(triphenyl-l5-phosphanylidene)hexanoate |
| ROSU-010 | 147118-38-5 | methyl (R,E)-3-((tert-butyldimethylsilyl)oxy)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)-5-oxohept-6-enoate |
| ROSU-011 | 147118-39-6 | methyl (R,E)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)-3-hydroxy-5-oxohept-6-enoate |
| ROSU-012 | 147118-40-9 | methyl (3R,5S,E)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)-3,5-dihydroxyhept-6-enoate |
| ROSU-013 | 147098-18-8 | sodium (3R,5S,E)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)-3,5-dihydroxyhept-6-enoate |
OptimisedRoute 2Steps 10 · Total yield /
ROSU-014714963-27-6ROSU-015866088-06-4ROSU-016866088-07-5ROSU-017866088-08-6ROSU-018116563-00-9ROSU-019866114-13-8ROSU-020289042-10-0ROSU-021866088-09-7ROSU-022—ROSU-023—ROSU-024503610-43-3API · Rosuvastatin Calcium
| Code | CAS No. | Intermediate |
|---|---|---|
| ROSU-014 | 714963-27-6 | (4R,6S)-6-(chloromethyl)tetrahydro-2H-pyran-2,4-diol |
| ROSU-015 | 866088-06-4 | (2S,4R)-2-(chloromethyl)-6-methoxytetrahydro-2H-pyran-4-ol |
| ROSU-016 | 866088-07-5 | (2S,4R)-4-(benzyloxy)-2-(chloromethyl)-6-methoxytetrahydro-2H-pyran |
| ROSU-017 | 866088-08-6 | ((2S,4R)-4-(benzyloxy)-6-methoxytetrahydro-2H-pyran-2-yl)methyl acetate |
| ROSU-018 | 116563-00-9 | ((2S,4R)-4-(benzyloxy)-6-methoxytetrahydro-2H-pyran-2-yl)methanol |
| ROSU-019 | 866114-13-8 | (2S,4R)-4-(benzyloxy)-6-methoxytetrahydro-2H-pyran-2-carbaldehyde |
| ROSU-020 | 289042-10-0 | N-(5-((diphenylphosphoryl)methyl)-4-(4-fluorophenyl)-6-isopropylpyrimidin-2-yl)-N-methylmethanesulfonamide |
| ROSU-021 | 866088-09-7 | N-(5-((E)-2-((2S,4R)-4-(benzyloxy)-6-methoxytetrahydro-2H-pyran-2-yl)vinyl)-4-(4-fluorophenyl)-6-isopropylpyrimidin-2-yl)-N-methylmethanesulfonamide |
| ROSU-022 | - | N-(4-(4-fluorophenyl)-5-((E)-2-((2S,4R)-4-hydroxy-6-methoxytetrahydro-2H-pyran-2-yl)vinyl)-6-isopropylpyrimidin-2-yl)-N-methylmethanesulfonamide |
| ROSU-023 | - | N-(5-((E)-2-((2S,4R)-4,6-dihydroxytetrahydro-2H-pyran-2-yl)vinyl)-4-(4-fluorophenyl)-6-isopropylpyrimidin-2-yl)-N-methylmethanesulfonamide |
| ROSU-024 | 503610-43-3 | N-(4-(4-fluorophenyl)-5-((E)-2-((2S,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl)vinyl)-6-isopropylpyrimidin-2-yl)-N-methylmethanesulfonamide |
OptimisedRoute 3Steps 12 · Total yield 50 g
ROSU-008147118-37-4ROSU-013147098-18-8ROSU-025141942-85-0ROSU-026141942-82-7ROSU-027105876-28-6ROSU-0281644395-21-0ROSU-0291644395-22-1ROSU-030908274-86-2ROSU-03179-22-1ROSU-032908274-87-3ROSU-0331779-49-3ROSU-034908274-88-4ROSU-035676256-39-6ROSU-036615556-96-2ROSU-037355806-00-7API · Rosuvastatin Calcium
| Code | CAS No. | Intermediate |
|---|---|---|
| ROSU-008 | 147118-37-4 | N-(4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl)-N-methylmethanesulfonamide |
| ROSU-013 | 147098-18-8 | sodium (3R,5S,E)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)-3,5-dihydroxyhept-6-enoate |
| ROSU-025 | 141942-85-0 | ethyl (R)-4-cyano-3-hydroxybutanoate |
| ROSU-026 | 141942-82-7 | ethyl (R)-3-((tert-butyldimethylsilyl)oxy)-4-cyanobutanoate |
| ROSU-027 | 105876-28-6 | (R)-3-((tert-butyldimethylsilyl)oxy)-4-cyanobutanoic acid |
| ROSU-028 | 1644395-21-0 | tert-butyl (R)-3-((tert-butyldimethylsilyl)oxy)-4-cyanobutanoate |
| ROSU-029 | 1644395-22-1 | tert-butyl (R)-5-amino-3-((tert-butyldimethylsilyl)oxy)-5-oxopentanoate |
| ROSU-030 | 908274-86-2 | (R)-5-(tert-butoxy)-3-((tert-butyldimethylsilyl)oxy)-5-oxopentanoic acid |
| ROSU-031 | 79-22-1 | methyl carbonochloridate |
| ROSU-032 | 908274-87-3 | (S)-(R)-5-(tert-butoxy)-3-((tert-butyldimethylsilyl)oxy)-5-oxopentanoic (ethyl carbonic) anhydride |
| ROSU-033 | 1779-49-3 | methyltriphenylphosphonium bromide |
| ROSU-034 | 908274-88-4 | tert-butyl (R)-3-((tert-butyldimethylsilyl)oxy)-5-oxo-6-(triphenyl-l5-phosphanylidene)hexanoate |
| ROSU-035 | 676256-39-6 | tert-butyl (R,E)-3-((tert-butyldimethylsilyl)oxy)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)-5-oxohept-6-enoate |
| ROSU-036 | 615556-96-2 | tert-butyl (R,E)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)-3-hydroxy-5-oxohept-6-enoate |
| ROSU-037 | 355806-00-7 | tert-butyl (3R,5S,E)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)-3,5-dihydroxyhept-6-enoate |
OptimisedRoute 4Steps 7 · Total yield 4.38 g
ROSU-008147118-37-4ROSU-03179-22-1ROSU-0331779-49-3ROSU-03891424-40-7ROSU-0393886-69-9ROSU-040121331-25-7ROSU-04191424-38-3ROSU-0421360110-92-4ROSU-0431360110-94-6ROSU-0441456783-25-7ROSU-0451456783-26-8API · Rosuvastatin Calcium
| Code | CAS No. | Intermediate |
|---|---|---|
| ROSU-008 | 147118-37-4 | N-(4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl)-N-methylmethanesulfonamide |
| ROSU-031 | 79-22-1 | methyl carbonochloridate |
| ROSU-033 | 1779-49-3 | methyltriphenylphosphonium bromide |
| ROSU-038 | 91424-40-7 | 4-((tert-butyldimethylsilyl)oxy)dihydro-2H-pyran-2,6(3H)-dione |
| ROSU-039 | 3886-69-9Available | (R)-1-phenylethan-1-amine |
| ROSU-040 | 121331-25-7 | (S)-3-((tert-butyldimethylsilyl)oxy)-5-oxo-5-(((R)-1-phenylethyl)amino)pentanoic acid |
| ROSU-041 | 91424-38-3 | (S)-3-((tert-butyldimethylsilyl)oxy)-5-oxo-5-(((R)-1-phenylethyl)amino)pentanoic (methyl carbonic) anhydride |
| ROSU-042 | 1360110-92-4 | (R)-3-((tert-butyldimethylsilyl)oxy)-5-oxo-N-((R)-1-phenylethyl)-6-(triphenyl-l5-phosphanylidene)hexanamide |
| ROSU-043 | 1360110-94-6 | (R,E)-3-((tert-butyldimethylsilyl)oxy)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)-5-oxo-N-((R)-1-phenylethyl)hept-6-enamide |
| ROSU-044 | 1456783-25-7 | (R,E)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)-3-hydroxy-5-oxo-N-((R)-1-phenylethyl)hept-6-enamide |
| ROSU-045 | 1456783-26-8 | (3R,5S,E)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)-3,5-dihydroxy-N-((R)-1-phenylethyl)hept-6-enamide |
ProcessRoute 5Steps 8 · Total yield 1.67 kg
ROSU-001459-57-4ROSU-020289042-10-0ROSU-024503610-43-3ROSU-04642558-54-3ROSU-04757-13-6ROSU-048488798-36-3ROSU-049488798-37-4ROSU-0501184-85-6ROSU-051289042-11-1ROSU-052147118-36-3ROSU-053799842-07-2ROSU-055172405-02-6ROSU-056—API · Rosuvastatin Calcium
| Code | CAS No. | Intermediate |
|---|---|---|
| ROSU-001 | 459-57-4 | 4-fluorobenzaldehyde |
| ROSU-020 | 289042-10-0 | N-(5-((diphenylphosphoryl)methyl)-4-(4-fluorophenyl)-6-isopropylpyrimidin-2-yl)-N-methylmethanesulfonamide |
| ROSU-024 | 503610-43-3 | N-(4-(4-fluorophenyl)-5-((E)-2-((2S,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl)vinyl)-6-isopropylpyrimidin-2-yl)-N-methylmethanesulfonamide |
| ROSU-046 | 42558-54-3 | methyl 4-methyl-3-oxopentanoate |
| ROSU-047 | 57-13-6 | urea |
| ROSU-048 | 488798-36-3 | methyl 4-(4-fluorophenyl)-6-isopropyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate |
| ROSU-049 | 488798-37-4 | methyl 4-(4-fluorophenyl)-2-hydroxy-6-isopropylpyrimidine-5-carboxylate |
| ROSU-050 | 1184-85-6 | N-methylmethanesulfonamide |
| ROSU-051 | 289042-11-1 | methyl 4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidine-5-carboxylate |
| ROSU-052 | 147118-36-3 | N-(4-(4-fluorophenyl)-5-(hydroxymethyl)-6-isopropylpyrimidin-2-yl)-N-methylmethanesulfonamide |
| ROSU-053 | 799842-07-2 | N-(5-(bromomethyl)-4-(4-fluorophenyl)-6-isopropylpyrimidin-2-yl)-N-methylmethanesulfonamide |
| ROSU-055 | 172405-02-6 | tert-butyl (4S,6S)-6-formyl-2,2-dimethyl-1,3-dioxane-4-carboxylate |
| ROSU-056 | - | tert-butyl (4S,6S)-6-((E)-2-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)vinyl)-2,2-dimethyl-1,3-dioxane-4-carboxylate |
Frequently asked questions
What are the approved indications of Rosuvastatin Calcium?
Approved indications include: Homozygous familial hypercholesterolaemia, Heterozygous familial hypercholesterolaemia, Hyperlipoproteinaemia type III, Atherosclerosis, Hyperlipoproteinaemia type II, Hypercholesterolaemia, Dyslipidaemia.
When does the Rosuvastatin Calcium patent expire?
No public expiry year is available for Rosuvastatin Calcium yet; this page updates once verified.
How many synthesis routes are recorded for Rosuvastatin Calcium?
5 synthesis routes are recorded; the shortest is 7 steps with 4.38 g total yield. Intermediates in each route carry codes and CAS numbers.
Where can I buy Rosuvastatin Calcium intermediates?
1 intermediate CAS of Rosuvastatin Calcium are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.
How do I get a quote for Rosuvastatin Calcium intermediates?
Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.
Source: cross-verified data (structured fields only) · 2026-09-29