Bupivacaine Hydrochloride/Fentanyl Citrate

Tier C — Watch / trade

Amco

Originator

2012

First approval

Expiry (public)

No sales data

Peak sales

Small molecule

Type

Targets：Opioid receptors, SCNA

Brand：Bufyl

Indications (approved)：Pain

Regional status

Approved

2012-01-01

China

Japan

Factories producing this API11

Factories registered as producing this API in our sourcing network (RFQ records + product master), sorted by RFQ activity; the snapshot carries no cost or customer data.

11 producing factories on file — sign in to view the named list (factory details are not shown to guests).

Synthetic routes & intermediates4 routes

Originator routes × 0Optimised (non-patent) × 4Process routes × 0

Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.

OptimisedRoute 1Steps 3 · Total yield /

(I)91311-1-a535-75-1(II)91311-1-a71170-88-2(III)91311-1-a87-62-7(IV)91311-1-a—(V)91311-1-a15883-20-2(VI)91311-1-a109-65-9API · Bupivacaine Hydrochloride/Fentanyl Citrate

Code	CAS No.	Intermediate
(I)91311-1-a	535-75-1	(+/-)-Piperidine-2-carboxylic acid
(II)91311-1-a	71170-88-2	1-[(Benzyloxy)carbonyl]piperidine-2-carboxylic acid
(III)91311-1-a	87-62-7 Available	2-Amino-1,3-dimethylbenzene
(IV)91311-1-a	-	Phenyl 2-[(2,6-dimethylphenyl)carbamoyl]piperidine-1-carboxylate
(V)91311-1-a	15883-20-2 Available	(RS)-N-(2,6-Dimethylphenyl)piperidine-2-carboxamide
(VI)91311-1-a	109-65-9	1-Bromobutane

OptimisedRoute 2Steps 4 · Total yield /

(I)91311-2-a535-75-1(II)91311-2-a15862-86-9(III)91311-2-a36293-02-4(IV)91311-2-a87-62-7(V)91311-2-a15883-20-2(VI)91311-2-a109-65-9API · Bupivacaine Hydrochloride/Fentanyl Citrate

Code	CAS No.	Intermediate
(I)91311-2-a	535-75-1	(+/-)-Piperidine-2-carboxylic acid
(II)91311-2-a	15862-86-9	DL-Pipecolic acid hydrochloride
(III)91311-2-a	36293-02-4	Piperidine-2-carbonyl chloride hydrogen chloride
(IV)91311-2-a	87-62-7 Available	2-Amino-1,3-dimethylbenzene
(V)91311-2-a	15883-20-2 Available	(RS)-N-(2,6-Dimethylphenyl)piperidine-2-carboxamide
(VI)91311-2-a	109-65-9	1-Bromobutane

OptimisedRoute 3Steps 1 · Total yield /

(I)91311-3-a87-62-7(II)91311-3-a—(III)91311-3-a—API · Bupivacaine Hydrochloride/Fentanyl Citrate

Code	CAS No.	Intermediate
(I)91311-3-a	87-62-7 Available	2-Amino-1,3-dimethylbenzene
(II)91311-3-a	-	1-Butylpiperidine-2-carbaldehyde
(III)91311-3-a	-	1-Butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide

OptimisedRoute 1Steps 3 · Total yield 1.53 g (Fentanyl)

FENT-001320589-77-3FENT-002103-63-9FENT-00339742-60-4FENT-00462-53-3FENT-00521409-26-7FENT-00679-03-8API · Bupivacaine Hydrochloride/Fentanyl Citrate

Code	CAS No.	Intermediate
FENT-001	320589-77-3	piperidin-4-one hydrochloride hydrate
FENT-002	103-63-9	(2-bromoethyl)benzene
FENT-003	39742-60-4	1-phenethylpiperidin-4-one
FENT-004	62-53-3 Available	aniline
FENT-005	21409-26-7	1-phenethyl-N-phenylpiperidin-4-amine
FENT-006	79-03-8	(8R,9S,10R,13S,14S,17R)-17-(2-hydroxyacetyl)-10,13-dimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl pentanoate

Frequently asked questions

What are the approved indications of Bupivacaine Hydrochloride/Fentanyl Citrate?

Approved indications include: Pain.

When does the Bupivacaine Hydrochloride/Fentanyl Citrate patent expire?

No public expiry year is available for Bupivacaine Hydrochloride/Fentanyl Citrate yet; this page updates once verified.

How many synthesis routes are recorded for Bupivacaine Hydrochloride/Fentanyl Citrate?

4 synthesis routes are recorded; the shortest is 1 steps with / total yield. Intermediates in each route carry codes and CAS numbers.

Where can I buy Bupivacaine Hydrochloride/Fentanyl Citrate intermediates?

3 intermediate CAS of Bupivacaine Hydrochloride/Fentanyl Citrate are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.

How do I get a quote for Bupivacaine Hydrochloride/Fentanyl Citrate intermediates?

Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.

Source: cross-verified data (structured fields only) · 2026-09-29