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Pioglitazone Hydrochloride
Tier B — Position earlyPioglitazone Hydrochloride
Takeda Pharmaceutical Company Limited
Originator
1999
First approval
-
Expiry (public)
$4.38B ▲
Peak sales
Small molecule
Type
Targets：PPARγ
Brand：Actos, Glustin
Indications (approved)：Type 2 diabetes
Regional status
US
Approved
1999-07-15
EU
Withdrawn
China
Approved
2001-02-05
Japan
Approved
1999-09-22
Synthetic routes & intermediates5 routes
Originator routes × 1Optimised (non-patent) × 4Process routes × 0
Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.
OriginatorRoute 1Steps 5 · Total yield 20.50 g
PIOG-0015223-06-3PIOG-002100-02-7PIOG-00385583-54-6PIOG-00485583-40-0PIOG-005140-88-5PIOG-006881847-12-7PIOG-00762-56-6PIOG-008914249-67-5API · Pioglitazone Hydrochloride
| Code | CAS No. | Intermediate |
|---|---|---|
| PIOG-001 | 5223-06-3 | 2-(5-ethylpyridin-2-yl)ethan-1-ol |
| PIOG-002 | 100-02-7Available | 4-nitrophenol |
| PIOG-003 | 85583-54-6 | 5-ethyl-2-(2-(4-nitrophenoxy)ethyl)pyridine |
| PIOG-004 | 85583-40-0 | 4-(2-(5-ethylpyridin-2-yl)ethoxy)aniline |
| PIOG-005 | 140-88-5Available | ethyl acrylate |
| PIOG-006 | 881847-12-7 | ethyl 2-bromo-3-(4-(2-(5-ethylpyridin-2-yl)ethoxy)phenyl)propanoate |
| PIOG-007 | 62-56-6Available | thiourea |
| PIOG-008 | 914249-67-5 | 5-(4-(2-(5-ethylpyridin-2-yl)ethoxy)benzyl)-4-iminothiazolidin-2-one |
OptimisedRoute 2Steps 4 · Total yield 0.65 g
PIOG-0015223-06-3PIOG-0091194-02-1PIOG-010136402-00-1PIOG-011114393-97-4PIOG-0122295-31-0PIOG-013144809-28-9API · Pioglitazone Hydrochloride
| Code | CAS No. | Intermediate |
|---|---|---|
| PIOG-001 | 5223-06-3 | 2-(5-ethylpyridin-2-yl)ethan-1-ol |
| PIOG-009 | 1194-02-1Available | 4-fluorobenzonitrile |
| PIOG-010 | 136402-00-1 | 4-(2-(5-ethylpyridin-2-yl)ethoxy)benzonitrile |
| PIOG-011 | 114393-97-4 | 4-(2-(5-ethylpyridin-2-yl)ethoxy)benzaldehyde |
| PIOG-012 | 2295-31-0 | thiazolidine-2,4-dione |
| PIOG-013 | 144809-28-9 | (Z)-5-(4-(2-(5-ethylpyridin-2-yl)ethoxy)benzylidene)thiazolidine-2,4-dione |
OptimisedRoute 3Steps 5 · Total yield 49.60 kg
PIOG-0015223-06-3PIOG-011114393-97-4PIOG-0122295-31-0PIOG-013144809-28-9PIOG-014144809-26-7PIOG-015123-08-0API · Pioglitazone Hydrochloride
| Code | CAS No. | Intermediate |
|---|---|---|
| PIOG-001 | 5223-06-3 | 2-(5-ethylpyridin-2-yl)ethan-1-ol |
| PIOG-011 | 114393-97-4 | 4-(2-(5-ethylpyridin-2-yl)ethoxy)benzaldehyde |
| PIOG-012 | 2295-31-0 | thiazolidine-2,4-dione |
| PIOG-013 | 144809-28-9 | (Z)-5-(4-(2-(5-ethylpyridin-2-yl)ethoxy)benzylidene)thiazolidine-2,4-dione |
| PIOG-014 | 144809-26-7 | 2-(5-ethylpyridin-2-yl)ethyl methanesulfonate |
| PIOG-015 | 123-08-0Available | 4-hydroxybenzaldehyde |
OptimisedRoute 4Steps 7 · Total yield 1.10 g
PIOG-0122295-31-0PIOG-015123-08-0PIOG-0165408-74-2PIOG-017646519-81-5PIOG-018471295-98-4PIOG-019471295-99-5PIOG-020101931-00-4PIOG-021646519-88-2API · Pioglitazone Hydrochloride
| Code | CAS No. | Intermediate |
|---|---|---|
| PIOG-012 | 2295-31-0 | thiazolidine-2,4-dione |
| PIOG-015 | 123-08-0Available | 4-hydroxybenzaldehyde |
| PIOG-016 | 5408-74-2 | 5-ethyl-2-vinylpyridine |
| PIOG-017 | 646519-81-5 | 2-bromo-1-(5-ethylpyridin-2-yl)ethan-1-ol |
| PIOG-018 | 471295-98-4 | 4-(2-(5-ethylpyridin-2-yl)-2-hydroxyethoxy)benzaldehyde |
| PIOG-019 | 471295-99-5 | (Z)-5-(4-(2-(5-ethylpyridin-2-yl)-2-hydroxyethoxy)benzylidene)thiazolidine-2,4-dione |
| PIOG-020 | 101931-00-4 | 5-(4-(2-(5-ethylpyridin-2-yl)-2-hydroxyethoxy)benzyl)thiazolidine-2,4-dione |
| PIOG-021 | 646519-88-2 | 5-(4-(2-chloro-2-(5-ethylpyridin-2-yl)ethoxy)benzyl)thiazolidine-2,4-dione |
OptimisedRoute 5Steps 9 · Total yield 0.04 g
PIOG-0015223-06-3PIOG-0122295-31-0PIOG-015123-08-0PIOG-018471295-98-4PIOG-02290643-32-6PIOG-023646519-86-0PIOG-024646519-83-7PIOG-025646519-82-6PIOG-026646520-00-5PIOG-027646519-92-8PIOG-028646519-93-9API · Pioglitazone Hydrochloride
| Code | CAS No. | Intermediate |
|---|---|---|
| PIOG-001 | 5223-06-3 | 2-(5-ethylpyridin-2-yl)ethan-1-ol |
| PIOG-012 | 2295-31-0 | thiazolidine-2,4-dione |
| PIOG-015 | 123-08-0Available | 4-hydroxybenzaldehyde |
| PIOG-018 | 471295-98-4 | 4-(2-(5-ethylpyridin-2-yl)-2-hydroxyethoxy)benzaldehyde |
| PIOG-022 | 90643-32-6 | 5-ethyl-2-(2-hydroxyethyl)pyridine 1-oxide |
| PIOG-023 | 646519-86-0 | 1-(5-ethylpyridin-2-yl)ethane-1,2-diyl diacetate |
| PIOG-024 | 646519-83-7 | 1-(5-ethylpyridin-2-yl)ethane-1,2-diol |
| PIOG-025 | 646519-82-6 | 4-(5-ethylpyridin-2-yl)-1,3,2-dioxathiolane 2-oxide |
| PIOG-026 | 646520-00-5 | 1-(5-ethylpyridin-2-yl)-2-(4-formylphenoxy)ethyl 4-methylbenzenesulfonate |
| PIOG-027 | 646519-92-8 | (Z)-2-(4-((2,4-dioxothiazolidin-5-ylidene)methyl)phenoxy)-1-(5-ethylpyridin-2-yl)ethyl 4-methylbenzenesulfonate |
| PIOG-028 | 646519-93-9 | 2-(4-((2,4-dioxothiazolidin-5-yl)methyl)phenoxy)-1-(5-ethylpyridin-2-yl)ethyl 4-methylbenzenesulfonate |
Frequently asked questions
What are the approved indications of Pioglitazone Hydrochloride?
Approved indications include: Type 2 diabetes.
When does the Pioglitazone Hydrochloride patent expire?
No public expiry year is available for Pioglitazone Hydrochloride yet; this page updates once verified.
How many synthesis routes are recorded for Pioglitazone Hydrochloride?
5 synthesis routes are recorded; the shortest is 4 steps with 0.65 g total yield. Intermediates in each route carry codes and CAS numbers.
Where can I buy Pioglitazone Hydrochloride intermediates?
5 intermediate CAS of Pioglitazone Hydrochloride are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.
How do I get a quote for Pioglitazone Hydrochloride intermediates?
Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.
Source: cross-verified data (structured fields only) · 2026-09-29