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Ivabradine Hydrochloride/Metoprolol Tartrate

Tier C — Watch / trade

Ivabradine Hydrochloride/Metoprolol Tartrate

Laboratoires Servier
Originator
2015
First approval
-
Expiry (public)
No sales data
Peak sales
Small molecule
Type

Targets:β-adrenoceptors, HCN channels

Brand:Implicor

Indications (approved):Angina pectoris

Regional status

US
-
EU
Approved
2015-01-01
China
-
Japan
-

Factories producing this API9

Factories registered as producing this API in our sourcing network (RFQ records + product master), sorted by RFQ activity; the snapshot carries no cost or customer data.

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Synthetic routes & intermediates6 routes

Originator routes × 0Optimised (non-patent) × 5Process routes × 1

Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.

OptimisedRoute 2Steps 1 · Total yield /
METOPR-00456718-78-6API · Ivabradine Hydrochloride/Metoprolol Tartrate
CodeCAS No.Intermediate
METOPR-00456718-78-63-isopropyl-5-((4-(2-methoxyethyl)phenoxy)methyl)oxazolidin-2-one
OptimisedRoute 3Steps 2 · Total yield /
METOPR-00356718-70-8METOPR-00574027-60-4API · Ivabradine Hydrochloride/Metoprolol Tartrate
CodeCAS No.Intermediate
METOPR-00356718-70-82-((4-(2-methoxyethyl)phenoxy)methyl)oxirane
METOPR-00574027-60-41-amino-3-(4-(2-methoxyethyl)phenoxy)propan-2-ol
OptimisedRoute 4Steps 2 · Total yield /
METOPR-00156718-71-9METOPR-00623946-21-6METOPR-007—API · Ivabradine Hydrochloride/Metoprolol Tartrate
CodeCAS No.Intermediate
METOPR-00156718-71-94-(2-methoxyethyl)phenol
METOPR-00623946-21-61-(benzyl(isopropyl)amino)-3-chloropropan-2-ol
METOPR-007-1-(benzyl(isopropyl)amino)-3-(4-(2-methoxyethyl)phenoxy)propan-2-ol
OptimisedRoute 5Steps 3 · Total yield /
METOPR-00156718-71-9METOPR-0081713-85-5METOPR-00956392-15-5METOPR-01056718-79-7API · Ivabradine Hydrochloride/Metoprolol Tartrate
CodeCAS No.Intermediate
METOPR-00156718-71-94-(2-methoxyethyl)phenol
METOPR-0081713-85-53-chloro-2-hydroxypropanoic acid
METOPR-00956392-15-52-hydroxy-3-(4-(2-methoxyethyl)phenoxy)propanoic acid
METOPR-01056718-79-72-hydroxy-N-isopropyl-3-(4-(2-methoxyethyl)phenoxy)propanamide
OptimisedRoute 6Steps 2 · Total yield 0.62 g
METOPR-00156718-71-9METOPR-011106-95-6METOPR-01280448-05-1API · Ivabradine Hydrochloride/Metoprolol Tartrate
CodeCAS No.Intermediate
METOPR-00156718-71-94-(2-methoxyethyl)phenol
METOPR-011106-95-6Available3-bromoprop-1-ene
METOPR-01280448-05-11-(allyloxy)-4-(2-methoxyethyl)benzene
ProcessRoute 1Steps 2 · Total yield 1.2 kg
METOPR-00156718-71-9METOPR-002106-89-8METOPR-00356718-70-8Metoprolol51384-51-1API · Ivabradine Hydrochloride/Metoprolol Tartrate
CodeCAS No.Intermediate
METOPR-00156718-71-94-(2-methoxyethyl)phenol
METOPR-002106-89-82-(chloromethyl)oxirane
METOPR-00356718-70-82-((4-(2-methoxyethyl)phenoxy)methyl)oxirane
Metoprolol51384-51-11-(isopropylamino)-3-(4-(2-methoxyethyl)phenoxy)propan-2-ol

Frequently asked questions

What are the approved indications of Ivabradine Hydrochloride/Metoprolol Tartrate?

Approved indications include: Angina pectoris.

When does the Ivabradine Hydrochloride/Metoprolol Tartrate patent expire?

No public expiry year is available for Ivabradine Hydrochloride/Metoprolol Tartrate yet; this page updates once verified.

How many synthesis routes are recorded for Ivabradine Hydrochloride/Metoprolol Tartrate?

6 synthesis routes are recorded; the shortest is 1 steps with / total yield. Intermediates in each route carry codes and CAS numbers.

Where can I buy Ivabradine Hydrochloride/Metoprolol Tartrate intermediates?

1 intermediate CAS of Ivabradine Hydrochloride/Metoprolol Tartrate are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.

How do I get a quote for Ivabradine Hydrochloride/Metoprolol Tartrate intermediates?

Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.

Source: cross-verified data (structured fields only) · 2026-09-29