Pazopanib Hydrochloride

Tier C — Watch / trade

GSK

Originator

2009

First approval

Expiry (public)

$0.83B ▲

Peak sales

Small molecule

Type

Targets：VEGFR1, KIT, VEGFR3, CSF1R, PDGFR-β, ITK, FGFR1, LCK, FGFR3, VEGFR2, PDGFR-α

Brand：Patorma, Votrient, Armala

Indications (approved)：Renal cell carcinoma, Sarcoma, Soft tissue neoplasm

Regional status

Approved

2009-10-19

Approved

2010-06-14

China

Approved

2017-02-21

Japan

Approved

2012-09-28

Synthetic routes & intermediates1 routes

Originator routes × 1Optimised (non-patent) × 0Process routes × 0

Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.

OriginatorRoute 1Steps 7 · Total yield /

Code	CAS No.	Intermediate
PAZO-001	578-54-1 Available	2-ethylaniline
PAZO-002	20191-74-6 Available	2-ethyl-5-nitroaniline
PAZO-003	6494-19-5 Available	3-methyl-6-nitro-1H-indazole
PAZO-004	444731-73-1 Available	2,3-dimethyl-6-nitro-2H-indazole
PAZO-005	635702-60-2 Available	2,3-dimethyl-2H-indazol-6-amine hydrochloride
PAZO-006	3934-20-1 Available	2,4-dichloropyrimidine
PAZO-007	444731-74-2 Available	N-(2-chloropyrimidin-4-yl)-2,3-dimethyl-2H-indazol-6-amine
PAZO-008	444731-75-3 Available	N-(2-chloropyrimidin-4-yl)-N,2,3-trimethyl-2H-indazol-6-amine
PAZO-009	6973-09-7 Available	5-amino-2-methylbenzenesulfonamide

Frequently asked questions

What are the approved indications of Pazopanib Hydrochloride?

Approved indications include: Renal cell carcinoma, Sarcoma, Soft tissue neoplasm.

When does the Pazopanib Hydrochloride patent expire?

No public expiry year is available for Pazopanib Hydrochloride yet; this page updates once verified.

How many synthesis routes are recorded for Pazopanib Hydrochloride?

1 synthesis routes are recorded; the shortest is 7 steps with / total yield. Intermediates in each route carry codes and CAS numbers.

Where can I buy Pazopanib Hydrochloride intermediates?

9 intermediate CAS of Pazopanib Hydrochloride are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.

How do I get a quote for Pazopanib Hydrochloride intermediates?

Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.

Source: cross-verified data (structured fields only) · 2026-09-29