Teriflunomide Sodium

Tier C — Watch / trade

Originator

First approval

Expiry (public)

No sales data

Peak sales

Small molecule

Type

Targets：DHODH

Indications (approved)：Systemic lupus erythematosus

Regional status

China

Phase II

2019-05-14

Japan

Synthetic routes & intermediates7 routes

Originator routes × 1Optimised (non-patent) × 5Process routes × 1

Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.

OriginatorRoute 1Steps 6 · Total yield 46.0 g

TERI-001141-97-9TERI-0023788-94-1TERI-00351135-73-0TERI-00442831-50-5TERI-00567305-24-2TERI-006455-14-1TERI-00775706-12-6Teriflunomide163451-81-8API · Teriflunomide Sodium

Code	CAS No.	Intermediate
TERI-001	141-97-9 Available	ethyl 3-oxobutanoate
TERI-002	3788-94-1	ethyl (Z)-2-(ethoxymethylene)-3-oxobutanoate
TERI-003	51135-73-0	ethyl 5-methylisoxazole-4-carboxylate
TERI-004	42831-50-5	5-methylisoxazole-4-carboxylic acid
TERI-005	67305-24-2	5-methylisoxazole-4-carbonyl chloride
TERI-006	455-14-1	4-(trifluoromethyl)aniline
TERI-007	75706-12-6	5-methyl-N-(4-(trifluoromethyl)phenyl)isoxazole-4-carboxamide
Teriflunomide	163451-81-8	(Z)-2-Cyano-3-hydroxy-but-2-enoic acid-(4-trifluoromethylphenyl)-amide

OptimisedRoute 2Steps 2 · Total yield /

TERI-008372-09-8TERI-006455-14-1TERI-00924522-30-3Teriflunomide163451-81-8API · Teriflunomide Sodium

Code	CAS No.	Intermediate
TERI-008	372-09-8 Available	2-cyanoacetic acid
TERI-006	455-14-1	4-(trifluoromethyl)aniline
TERI-009	24522-30-3	2-cyano-N-(4-(trifluoromethyl)phenyl)acetamide
Teriflunomide	163451-81-8	(Z)-2-Cyano-3-hydroxy-but-2-enoic acid-(4-trifluoromethylphenyl)-amide

OptimisedRoute 3Steps 3 · Total yield 7.12 g

TERI-001141-97-9TERI-006455-14-1TERI-010351-87-1TERI-0111206724-43-7Teriflunomide163451-81-8API · Teriflunomide Sodium

Code	CAS No.	Intermediate
TERI-001	141-97-9 Available	ethyl 3-oxobutanoate
TERI-006	455-14-1	4-(trifluoromethyl)aniline
TERI-010	351-87-1	3-oxo-N-(4-(trifluoromethyl)phenyl)butanamide
TERI-011	1206724-43-7	2-bromo-3-oxo-N-(4-(trifluoromethyl)phenyl)butanamide
Teriflunomide	163451-81-8	(Z)-2-Cyano-3-hydroxy-but-2-enoic acid-(4-trifluoromethylphenyl)-amide

OptimisedRoute 4Steps 2 · Total yield 62 g

TERI-012105-56-6TERI-01387853-82-5TERI-006455-14-1Teriflunomide163451-81-8API · Teriflunomide Sodium

Code	CAS No.	Intermediate
TERI-012	105-56-6 Available	ethyl 2-cyanoacetate
TERI-013	87853-82-5	ethyl (Z)-2-cyano-3-hydroxybut-2-enoate
TERI-006	455-14-1	4-(trifluoromethyl)aniline
Teriflunomide	163451-81-8	(Z)-2-Cyano-3-hydroxy-but-2-enoic acid-(4-trifluoromethylphenyl)-amide

OptimisedRoute 6Steps 1 · Total yield 2.76 g

TERI-00924522-30-3Teriflunomide163451-81-8API · Teriflunomide Sodium

Code	CAS No.	Intermediate
TERI-009	24522-30-3	2-cyano-N-(4-(trifluoromethyl)phenyl)acetamide
Teriflunomide	163451-81-8	(Z)-2-Cyano-3-hydroxy-but-2-enoic acid-(4-trifluoromethylphenyl)-amide

OptimisedRoute 7Steps 3 · Total yield 10 g (Teriflunomide)

TERI-00442831-50-5TERI-00567305-24-2TERI-006455-14-1TERI-00775706-12-6Teriflunomide163451-81-8API · Teriflunomide Sodium

Code	CAS No.	Intermediate
TERI-004	42831-50-5	5-methylisoxazole-4-carboxylic acid
TERI-005	67305-24-2	5-methylisoxazole-4-carbonyl chloride
TERI-006	455-14-1	4-(trifluoromethyl)aniline
TERI-007	75706-12-6	5-methyl-N-(4-(trifluoromethyl)phenyl)isoxazole-4-carboxamide
Teriflunomide	163451-81-8	(Z)-2-Cyano-3-hydroxy-but-2-enoic acid-(4-trifluoromethylphenyl)-amide

ProcessRoute 5Steps 3 · Total yield 316 g

TERI-014455-24-3TERI-01549541-89-1TERI-0161548-13-6TERI-0172469-99-0Teriflunomide163451-81-8API · Teriflunomide Sodium

Code	CAS No.	Intermediate
TERI-014	455-24-3	4-(trifluoromethyl)benzoic acid
TERI-015	49541-89-1	4-(trifluoromethyl)benzoyl azide
TERI-016	1548-13-6	1-isocyanato-4-(trifluoromethyl)benzene
TERI-017	2469-99-0 Available	3-oxobutanenitrile
Teriflunomide	163451-81-8	(Z)-2-Cyano-3-hydroxy-but-2-enoic acid-(4-trifluoromethylphenyl)-amide

Frequently asked questions

What are the approved indications of Teriflunomide Sodium?

Approved indications include: Systemic lupus erythematosus.

When does the Teriflunomide Sodium patent expire?

No public expiry year is available for Teriflunomide Sodium yet; this page updates once verified.

How many synthesis routes are recorded for Teriflunomide Sodium?

7 synthesis routes are recorded; the shortest is 1 steps with 2.76 g total yield. Intermediates in each route carry codes and CAS numbers.

Where can I buy Teriflunomide Sodium intermediates?

4 intermediate CAS of Teriflunomide Sodium are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.

How do I get a quote for Teriflunomide Sodium intermediates?

Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.

Source: cross-verified data (structured fields only) · 2026-10-08