Vortioxetine Hydrobromide

Tier B — Position early

Takeda Pharmaceutical Company Limited

Originator

2013

First approval

Expiry (public)

$1.52B ▲

Peak sales

Small molecule

Type

Targets：5-HT7, 5-HT1B, 5-HT1A, 5-HT3, 5-HT1D, SERT

Brand：Brintellix, Brintellix/Trintellix, Trintellix

Indications (approved)：Major depressive disorder

Regional status

Approved

2013-09-30

Approved

2013-12-18

China

Approved

2017-11-21

Japan

Approved

2019-09-20

Factories producing this API2

Factories registered as producing this API in our sourcing network (RFQ records + product master), sorted by RFQ activity; the snapshot carries no cost or customer data.

2 producing factories on file — sign in to view the named list (factory details are not shown to guests).

Synthetic routes & intermediates4 routes

Originator routes × 1Optimised (non-patent) × 2Process routes × 1

Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.

OriginatorRoute 1Steps 5 · Total yield 13.3 g

Code	CAS No.	Intermediate
VORT-001	95-50-1	1,2-dichlorobenzene
VORT-002	97487-63-3	-
VORT-003	-	-
VORT-004	110-85-0 Available	piperazine
VORT-005	-	-
VORT-006	13616-82-5	2,4-dimethylbenzenethiol
VORT-007	-	-

OptimisedRoute 3Steps 5 · Total yield 2.15 g

Synthetic routes & intermediates Route 3

Code	CAS No.	Intermediate
VORT-006	13616-82-5	2,4-dimethylbenzenethiol
VORT-010	1493-27-2	1-fluoro-2-nitrobenzene
VORT-011	1610527-49-5	(2,4-dimethylphenyl)(2-nitrophenyl)sulfane
VORT-012	1019453-85-0	2-((2,4-dimethylphenyl)thio)aniline
VORT-013	1011513-93-1	bis(2-chloroethyl)amine hydrochloride

OptimisedRoute 4Steps 6 · Total yield 0.36 g

Synthetic routes & intermediates Route 4

Code	CAS No.	Intermediate
VORT-016	1639263-84-5	1-((2-fluorophenyl)sulfinyl)-2,4-dimethylbenzene
VORT-017	57260-71-6 Available	tert-butyl piperazine-1-carboxylate
VORT-018	1639263-79-8	tert-butyl 4-(2-((2,4-dimethylphenyl)sulfinyl)phenyl)piperazine-1-carboxylate
VORT-019	1429908-35-9	1-(2-((2,4-dimethylphenyl)sulfinyl)phenyl)piperazine
VORT-006	13616-82-5	2,4-dimethylbenzenethiol
VORT-014	367-11-3	1,2-difluorobenzene
VORT-015	1639263-82-3	(2,4-dimethylphenyl)(2-fluorophenyl)sulfane

ProcessRoute 2Steps 3 · Total yield 895 g

Synthetic routes & intermediates Route 2

Code	CAS No.	Intermediate
VORT-004	110-85-0 Available	piperazine
VORT-006	13616-82-5	2,4-dimethylbenzenethiol
VORT-008	583-55-1	1-bromo-2-iodobenzene
VORT-009	1011-13-8	1-(2-bromophenyl)piperazine

Frequently asked questions

What are the approved indications of Vortioxetine Hydrobromide?

Approved indications include: Major depressive disorder.

When does the Vortioxetine Hydrobromide patent expire?

No public expiry year is available for Vortioxetine Hydrobromide yet; this page updates once verified.

How many synthesis routes are recorded for Vortioxetine Hydrobromide?

4 synthesis routes are recorded; the shortest is 3 steps with 895 g total yield. Intermediates in each route carry codes and CAS numbers.

Where can I buy Vortioxetine Hydrobromide intermediates?

2 intermediate CAS of Vortioxetine Hydrobromide are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.

How do I get a quote for Vortioxetine Hydrobromide intermediates?

Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.

Source: cross-verified data (structured fields only) · 2026-09-29